Esophagogastric Cancers Secondary to a Breast Primary Tumor Do Not Require Resection

Ayantunde, Abraham; Agrawal, Amit; Parsons, Sarah; Welch, Neil T.

doi:10.1007/s00268-007-9099-y

Cited by 38 publications

(47 citation statements)

References 22 publications

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“…In the The clinical presentation of metastatic gastric tumors is often asymptomatic or non-specific unless the metastases invade the gastric mucosa or serosa (1). In cases of gastric metastasis arising from breast cancer, the incidence of hemorrhaging has been reported to be 12 to 33% (25,26). In the present study, gastrointestinal bleeding as the presenting symptom, together with melena or severe anemia, was observed in 81.8% of cases.…”

Section: Discussionmentioning

confidence: 61%

“…It has been reported that the majority of gastric metastases arising from lung cancer and malignant melanoma were detected within 2 years, most likely due to the rapid progression of these malignant tumors (2,4). By comparison, the time interval between the diagnosis of primary breast cancer and diagnosis of gastric metastasis was reported to be 4.0-6.5 years and the median survival period following treatment of these metastases was 10-20 months (25,26). Consistent with these findings was our finding in the present study that the IGM was 6.3 years for gastric metastasis arising from RCC and that the median survival period following treatment was 19 months.…”

Section: Discussionmentioning

confidence: 99%

“…Metastatic breast cancer with gastrointestinal tract involvement is evidence of a systemic disease and therefore systemic therapy, such as chemotherapy and/or hormonal therapy, rather than surgical resection is advised (25). Surgical resection is not advised for the treatment of gastric metastasis arising from breast cancer and surgical palliation is only indicated in emergency conditions to bypass obstructions in carefully selected patients (26). Molecular agents targeting metastatic RCC, including sorafenib and sunitinib, mark the start of a new era in the management of the disease with the potential to improve progression-free survival, objective response rate and quality of life (29).…”

Section: Discussionmentioning

confidence: 99%

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Metastatic gastric tumors arising from renal cell carcinoma: Clinical characteristics and outcomes of this uncommon disease

et al. 2012

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Abstract. We analyzed the clinicopathological characteristics and therapeutic outcomes of patients with metastatic gastric tumors arising from renal cell carcinoma (RCC) to identify post-therapy prognostic factors. A total of 22 patients who were treated for metastatic gastric tumors arising from RCC were included in the study. A retrospective review was performed on the clinical characteristics of this disease. The median time interval from radical excision of the primary tumor to the detection of gastric metastasis (IGM) was 6.3 years. The overall 1-and 3-year survival rates were 52.6 and 21.0%, respectively, and the median survival time was 19 months. Compared with patients with an IGM of <6.3 years, patients with an IGM of ≥6.3 years showed a significantly longer median survival time (5 vs. 24 months; P=0.017). The median tumor size was significantly greater in patients with multiple metastases compared with those with solitary metastasis (4 vs. 2 cm; P=0.036). The incidence of patients who had undergone therapeutic tumor resection was significantly higher in patients with solitary metastasis compared with those with multiple metastases (100.0 vs. 35.7%; P=0.019). The appearance of gastric tumors in patients with a history of RCC should prompt the clinician to investigate the possibility of metastasis even several years after detection of the original renal cancer. A longer interval from nephrectomy to the diagnosis of gastric metastasis is generally indicative of a better prognosis, most likely the result of less aggressive tumor growth.

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Section: Discussionmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Metastatic gastric tumors arising from renal cell carcinoma: Clinical characteristics and outcomes of this uncommon disease

et al. 2012

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“…Linitisplastica, secondary to breast lobular carcinoma, has a good response to hormonal manipulation or/and chemotherapy, particularly when metastatic foci are ER and PR positive. However, the overall prognosis is poor, with an average survival rate of two years following the diagnosis of the metastatic gastric lesions [26] .…”

Section: Discussionmentioning

confidence: 99%

Pyloric Metastases from Primary Breast Cancer- A Case Report and Literature Review

Al‐Zawi¹

2017

JMSCR

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“…These lesions are frequently seen on lungs, liver, bone, soft tissue, brain and adrenal glands. [1] The distal part of the esophagus is the most common site of lesions and they can appear with clinical signs of stricture, [2,3] with an incidence of 4% to 5% in some series reported in the literature. [4] The diagnosis of breast cancer metastases to the esophagus is difficult because there are no specific symptoms and many cases are found during autopsy or on the postoperative pathology report, there are only a few cases diagnosed with biopsy during endoscopic revision because an adequate specimen is difficult to acquire, The importance of identifying them relies on the fact that the only effective treatment is resection, either endoscopic or surgical.…”

Section: Introductionmentioning

confidence: 99%

Esophageal perforation due to breast cancer metastasis: Case report

Avendaño

Jiménez-López²,

Díaz

et al. 2017

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Introduction: Breast cancer metastasis to the esophagus is rare and can appear after a long period after remission. The lesions are frequently found on lung, liver, bone, soft tissue, brain and adrenal glands. Although the esophagus is a rare location, the distal part is the most common site of lesions and they can appear with clinical signs of stricture, with an incidence of 4% to 5% in some series reported in the literature. Case presentation: A 64-year-old woman with history of breast cancer treated with mastectomy, chemotherapy and radiotherapy currently in remission was referred to our center presenting stenosis of the esophagus and perforation that was treated with previously with a pleural patch that presented leakage requiring laparoscopic esophagectomy with gastric ascent. The patient had a good postoperative recovery, and was discharged to continue follow up as an outpatient. The surgical piece was examined with a final pathology report of breast cancer metastasis on the esophagus (ductal carcinoma) at the site of the stenosis and was referred to an Oncology service. Discussion: Although breast carcinoma represents a frequent source of metastases to the gastrointestinal tract, esophageal lesions are a rare entity. There is a low percentage of patients diagnosed endoscopically in the preoperative period due to the low incidence and the involvement of submucosa which makes obtaining a good sample difficult. These lesions can occur without symptomatology in a large number of patients, dysphagia is the most common symptom. Endoscopic resection is a suitable option with adequate results and is considered a safe method, however, is difficult to identify this pathology before it manifests clinically. In the scenario of complication, the minimally invasive approach provides a good option for a better postoperative recovery.

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Esophagogastric Cancers Secondary to a Breast Primary Tumor Do Not Require Resection

Cited by 38 publications

References 22 publications

Metastatic gastric tumors arising from renal cell carcinoma: Clinical characteristics and outcomes of this uncommon disease

Metastatic gastric tumors arising from renal cell carcinoma: Clinical characteristics and outcomes of this uncommon disease

Pyloric Metastases from Primary Breast Cancer- A Case Report and Literature Review

Esophageal perforation due to breast cancer metastasis: Case report

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