Esophagitis Secondary to Ingestion of Caustic Material

Symbas, Panagiotis N.; Vlasis, S.E.; Hatcher, Charles R.

doi:10.1016/s0003-4975(10)60653-4

Cited by 37 publications

(14 citation statements)

References 15 publications

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“…Damage to the gastrointestinal wall caused by an alkali is generally more severe than that caused by an acid, and corrosive esophagitis caused by an alkaline solution can therefore result in severe esophageal stricture. Symbas et al reported that 74 of 176 patients who had swallowed corrosive agents had esophagitis as determined by endoscopy and that esophageal stricture occurred in 29 of those 74 patients [2]. Treatments for esophageal stricture include conservative treatments such as bougie or balloon dilation, but when the stricture is long and severe, most cases need to be treated by surgical resection and reconstruction of the esophagus or a who had swallowed an alkaline solution; 2 of those 18 patients could be treated conservatively but 10 patients who had long and severe strictures require esophageal resection and reconstruction using colon [1].…”

Section: Discussionmentioning

confidence: 99%

“…Systemic administration of steroids and antibiotics has been reported in many cases of esophageal stricture [2,6]. According to some reports, systemic administration of steroids did not prevent the occurrence of esophageal stricture [7].…”

Section: Discussionmentioning

confidence: 99%

“…The damage is usually more severe in the esophagus than in stomach, because an alkali is neutralized by acid in the stomach. Esophageal stricture is treated by resection and reconstruction of the esophagus or conservatively by dilation using a bougie or balloon [1,2]. There have been few reports of successful results of conservative treatment [1,2].…”

Section: Introductionmentioning

confidence: 99%

“…Esophageal stricture is treated by resection and reconstruction of the esophagus or conservatively by dilation using a bougie or balloon [1,2]. There have been few reports of successful results of conservative treatment [1,2]. We experienced a case of esophageal stricture after caustic esophagitis in a 14-year-old girl that was successfully treated by frequent endoscopic balloon dilation and tranilast medication.…”

Section: Introductionmentioning

confidence: 99%

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A case of esophageal stricture after corrosive esophagitis successfully treated by frequent endoscopic balloon dilation

et al. 2004

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A 14-year-old girl was admitted to our hospital for treatment of abdominal pain after an attempt to commit suicide by swallowing a caustic soda solution. Severe esophageal stricture following corrosive esophagitis occurred 2 weeks after admission. First, we tried to dilate the stenotic esophagus by using an esophageal bougie, but it was not effective and was also painful, and the treatment was stopped. Next, we tried endoscopic balloon dilation. This procedure was less painful and more effective for dilating the stenotic esophagus than was the bougie. At first, we used a pneumatic balloon and injected a steroid locally under the mucosal layer after dilation. The same procedure was continued in the outpatient clinic, but each interval of the procedures, about 3 weeks, was not changed for about 1 year. After 1 year of consecutive trials of frequent dilatation using a pneumatic balloon, the type of balloon was changed to a hydrostatic type. Three months after changing the type of balloon, treatment with tranilast, which was expected to be effective for prevention of restenosis, was started instead of steroid injection to the stenotic portion. After starting tranilast treatment, the interval of dilation became longer and the stricture itself gradually became dilated. Twentyone months later, the interval of dilation was 3-4 months and oral intake had improved greatly. We therefore concluded that frequent endoscopic balloon dilation is effective for dilating stenosis after corrosive esophagitis. In addition, this case suggests that treatment with tranilast could be effective for preventing esophageal restenosis after balloon dilation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A case of esophageal stricture after corrosive esophagitis successfully treated by frequent endoscopic balloon dilation

et al. 2004

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“…Most patients with these lesions are children, with accidental ingestion of the lesive agent in a domestic environment 2,3 . In adults, although accidental ingestion does occur, the predominance is attempted suicide 4 .…”

Section: Introductionmentioning

confidence: 99%

Morphological and functional evaluation of distal esophagus of rabbits submitted to esophageal infusion with caustic soda

2008

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The ingestion of caustic substances is an important emergency situation, because of its serious consequences. Purpose: To study morphological and functional alterations of the esophagus in rabbits submitted to esophageal infusion of caustic soda (NaOH). Methods: The 88 rabbits studied were divided into 4 groups: G 1 (n=22) were submitted to esophageal infusion with distilled water. G 2 , G 3 , and G 4 were submitted to esophageal infusion of 2%, 4% and 6% NaOH respectively. Morphological alterations were studied in 12 animals from each group and manometric alterations in the remaining 10. An analysis was made of lower esophageal sphincter (LES) pressure, number and amplitude of contractions in the distal third of the esophagus. These studies were performed before (moment M1) and at 30 minutes, 6 hours, and 24 hours after (moments M2, M3, and M4, respectively) esophageal infusion. Results: Morphological evaluation: G1 -no alterations; G2 -edema, hyperemia, and ecdysis; G3 -enlarged calibre of esophagus, ulcers, ecdysis of mucosa; G4 -lesions similar to G3, but more intense, areas of extensive hemorrhage at M3 and M4. Functional evaluation: LES was higher at M2; the number of distal third lower esophageal contractions in G3, and G4 was lower; and the contraction amplitude was lower in G4. Conclusions: 1) Esophageal infusion with caustic soda in rabbits is a good experimental model for studying caustic esophagites. 2) Esophageal infusion with NaOH caused lesions in the esophageal wall, with gravity proportional to solution concentration; 3) Infusion caused LES spasm at M2, and reduced both contraction number and amplitude in the distal third of the esophagus. Key words: Sodium Hydroxide. Esophagus. Morphology. Evaluation Studies. Rabbits. RESUMOA ingestão de substâncias cáusticas constitui importante situação de emergência, tendo em vista a gravidade de suas seqüelas. Objetivo: Estudar as alterações morfológicas e funcionais do esôfago de coelhos submetidos à infusão esofágica com soda cáustica (NaOH). Métodos: 88 coelhos foram divididos em 4 grupos: G1 (n=22) foi submetido à infusão esofágica com água destilada; G2, G3 e G4 foram submetidos a infusão esofágica com NaOH a 2%, 4% e 6%, respectivamente. Alterações morfológicas foram estudadas em 12 animais de cada grupo e as alterações manométricas, nos 10 animais restantes. Foram feitas análises do esfíncter inferior do esôfago (EIE), número e amplitude das contrações no terço distal do esôfago. Estes estudos foram realizados antes (momento 1 -M1) e aos 30 minutos, 6 horas e 24 horas após a infusão esofágica (momentos M2, M3 e M4, respectivamente). Resultados: Avaliação macroscópica: G1 -sem alterações; G2 -edema, hiperemia e descamação; G3 -aumento do calibre do esôfago, úlceras, descamação da mucosa; G4 -lesões semelhantes as do G3, porém mais intensas, áreas de extensa hemorragia. Avaliação funcional: a pressão no EIE foi mais elevada em M2 no grupo 2; o número das contrações no terço distal do esôfago foi menor em G3 e G4, e a amplitude das contrações fo...

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Role of Histology and Cytology in Esophageal Diseases

Liu

Goldblum

2021

The Esophagus

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Esophagitis Secondary to Ingestion of Caustic Material

Cited by 37 publications

References 15 publications

A case of esophageal stricture after corrosive esophagitis successfully treated by frequent endoscopic balloon dilation

A case of esophageal stricture after corrosive esophagitis successfully treated by frequent endoscopic balloon dilation

Morphological and functional evaluation of distal esophagus of rabbits submitted to esophageal infusion with caustic soda

Role of Histology and Cytology in Esophageal Diseases

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