mortem series (1-3). If local invasion from adjacent organs is excluded, this phenomenon is observed in only 1% of patients with malignant disease (4). It has been reported that primary tumors of stomach, breast, larynx, tongue, bronchus, prostate, tibia, liver, and pleura have a tendency to metastasize to the esophagus (2,3,5-7). However, metastasis from endometrial carcinoma is a very rare occurrence. Herein, we report the case of an endometrial adenocarcinoma involving the esophagus that was refractory to second-line chemotherapy but was responsive to the single agent apatinib. We also review the literature.
Case presentation
Patient dataA 58-year-old woman underwent radical hysterectomy with bilateral salpingo-oophorectomy for endometrial adenocarcinoma in April 2014. Following this surgery, no radiation therapy and chemotherapy were administrated. She remained well until September 2016, when she was admitted to our hospital for progressive dysphagia and some lower abdominal pain for 3 months. A CT scan obtained at that time revealed a mass in the mid-esophagus (Figure 1) and esophagoscopy revealed a protruding lesion covered