Esophageal metastasis from endometrial adenocarcinoma: a case report and literature review

Fan, Wenna; Jiang, Haiping; Chen, Haidi; Wu, Lingjiao; Wang, Shaocheng; Wu, Fen

doi:10.21037/tcr.2018.06.08

Cited by 5 publications

(3 citation statements)

References 15 publications

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“…The mutation and polymorphism of protooncogenes, cancer suppressor genes, estrogen-related genes, estrogen/progesterone receptor genes can increase the risk of EC ( 2 ). The cancer cells invade the myometrium in the early stages of EC, but the recurrence, mortality, and prognosis of patients are mainly decided by the cancer cells’ direct extension/penetration, lymphatic metastasis, or migration to distal organs ( 3 ). Therefore, genetically clarifying the regulatory mechanism hiding behind EC development may supply a therapeutic target for EC.…”

Section: Introductionmentioning

confidence: 99%

Expression of YAP in endometrial carcinoma tissues and its effect on epithelial to mesenchymal transition

Cheng¹,

Huang²,

Han³

et al. 2020

Transl Cancer Res TCR

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Background: Yes-associated protein (YAP) can function as a cancer suppressor or a cancer promoter.Studies have proved that YAP can collaborate with other genes to accelerate cancerous epithelial to mesenchymal transition (EMT), but little is known about how YAP performs in endometrial carcinoma (EC).Methods: Real time-polymerase chain reaction (RT-PCR) and western blot (WB) were used to quantify the relative mRNA and protein levels of YAP in 50 EC tissue samples and 20 normal endometrial tissues in the proliferative phase. The association between YAP expression level and EC index (clinical stage, histologic grade, and lymphatic metastasis) was analyzed. YAP interference and overexpression vectors were constructed. RT-PCR and WB were used to quantify the mRNA and protein levels of YAP and EMT markers in the normal control group (N), the negative control group (NC), and the YAP interference and overexpression group. Cell counting kit-8 (CCK8) assay and scratch test were performed to evaluate the proliferation, invasion, and migration of EC cells after YAP interference and overexpression. Results:The mRNA and protein levels of YAP increased in EC tissues (P<0.01) and showed differences associated with histologic grade and lymphatic metastasis, not with the clinical stage (P>0.01). CCK8 assay showed that the proliferation of EC cells was inhibited after YAP interference and increased after YAP overexpression. The cell wound healing test displayed that the migration of EC cells was inhibited after YAP interference and increased after YAP overexpression. RT-PCR and WB found the mRNA and protein levels of E-cadherin (an EMT marker) increased (P<0.01), but those of other markers (N-cadherin, Vimentin) dropped (P<0.01) after YAP interference; however, these trends were inversed after YAP overexpression (P<0.01).Conclusions: YAP serves as an EC-promoting gene that may regulate the EMT and other EC-related processes via promoting the proliferation, invasion, and migration of EC cells.

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Section: Introductionmentioning

confidence: 99%

Expression of YAP in endometrial carcinoma tissues and its effect on epithelial to mesenchymal transition

Cheng¹,

Huang²,

Han³

et al. 2020

Transl Cancer Res TCR

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show abstract

“…, cervical, uterine, endometrial) were found to metastasize to the head and neck structures and in some cases result in dysphagia. 48 , 50 , 51 In fact, a meta-analysis from a review article found that hormone replacement therapy reduced the risk of head and neck cancers in women. 69 Future research should evaluate how hormonal status may affect swallowing perception, swallowing outcomes, and lung status for women with female-predominant or female-specific syndromes or disorders that affect swallowing structures.…”

Section: Discussionmentioning

confidence: 99%

The Relationship Between Menopause and Dysphagia: A Scoping Review

Lenell

Peña-Chávez

Burdick

et al. 2022

Women's Health Reports

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Purpose: Menopause marks the end of fertility and rapid decline of ovarian hormones in the female body, which corresponds to a myriad of changes to bodily systems, including the upper aerodigestive tract. Despite substantial evidence that menopause negatively impacts oral health, bones, and skeletal muscles, little research has examined these effects as they relate to swallowing. The purpose of this scoping review was to compile and summarize the existing literature investigating the relationship between menopause and swallowing-related structures and physiology. Methods: Search terms were selected for three databases (PubMed, Scopus, and CINAHL) to gather relevant literature evaluating the relationship between menopause and swallowing-related anatomy as well as swallowing functions in both human and animal models. Relevant articles were reviewed, collated, and summarized to synthesize findings, identify gaps in the literature, and provide suggestions for future directions. Results: This scoping review yielded 204 studies with the majority of these studies relating to one or more of the following categories: oral health, saliva, mandibular structures, and taste. Common oral symptoms reported in the literature included xerostomia, hyposalivation, tooth decay, inflammation of oral mucosa, and oral pain. Although literature supports that menopause adversely affects oral health, saliva, mandibular structures, and alters taste, a dearth of information was evident regarding how these hormone-dependent changes can adversely affect swallowing. Conclusions: The relationship between menopause and swallowing has been overlooked by field of speech–language pathology. By identifying the major gaps in the literature, these results will inform future investigations evaluating relationships among ovarian hormones and swallowing.

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“…Esophageal metastasis of breast cancer is rarely diagnosed, and the prevalence of esophageal metastasis from breast cancer is 4.2-5.9% (5,6). However, Borst and Ingold followed 2,246 breast cancer patients for an 18-year period and reported an esophageal metastasis prevalence of only 0.4% (7).…”

Section: Epidemiologymentioning

confidence: 99%

Review of esophageal metastasis from breast cancer

Su¹,

Wu²,

Liu³

et al. 2020

Gland Surg

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Esophageal metastasis of primary breast cancer is rare, with nearly all the literature on this topic consisting of case report studies. When breast cancer patients complain of progressive dysphagia after a long disease-free interval after breast surgery, they may be treated and misdiagnosed with a second primary. Our aim was to review all the literature concerning esophageal metastasis of breast cancer, for the purpose of improving the awareness in identifying these patients and providing them proper treatment.

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Esophageal metastasis from endometrial adenocarcinoma: a case report and literature review

Cited by 5 publications

References 15 publications

Expression of YAP in endometrial carcinoma tissues and its effect on epithelial to mesenchymal transition

Expression of YAP in endometrial carcinoma tissues and its effect on epithelial to mesenchymal transition

The Relationship Between Menopause and Dysphagia: A Scoping Review

Review of esophageal metastasis from breast cancer

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