Esophageal squamous papillomatosis

Kao, Patricia C; Vecchio, James; Schned, Laura M; Blaszyk, Hagen

doi:10.1097/00042737-200511000-00013

Cited by 14 publications

(15 citation statements)

References 12 publications

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“…The typical endoscopic appearance is a single, round, sessile lesion. However, our case, similar to other reports, demonstrates that it might present with multiple lesions [2,3]. Early reports suggested that this was a benign condition and endoscopic surveillance was unnecessary [4].…”

supporting

confidence: 89%

Esophageal papillomatosis complicated by squamous cell carcinoma

2012

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supporting

confidence: 89%

Esophageal papillomatosis complicated by squamous cell carcinoma

2012

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“…A total of 39 studies were considered eligible for the present analysis , comprising 427 esophageal papillomas analyzed by different HPV detection methods. Included are both case reports and larger series, comprising up to 82 samples analyzed by PCR and 33 papillomas examined by ISH (Table ).…”

Section: Resultsmentioning

confidence: 99%

“…Included are both case reports and larger series, comprising up to 82 samples analyzed by PCR and 33 papillomas examined by ISH (Table ). The methods used to evaluate the HPV involvement include the following: histological biopsy (HB) , IHC , DB , ISH , and PCR . Based on the available data on geographic regions with different HPV prevalence , the studies were categorized into the following regions of origin: China & Taiwan, Other Asia, Africa/Middle East, Europe, North America, and South America.…”

Section: Resultsmentioning

confidence: 99%

Detection of human papillomavirus in esophageal papillomas: systematic review and meta‐analysis

Syrjänen

2012

APMIS

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Since first suggested (in 1982), etiological role for human papillomavirus (HPV) in esophageal papillomas has aroused increasing interest. The objective of this study was to perform systematic review and formal meta-analysis of the literature reporting on HPV detection in esophageal squamous cell papillomas (ESCP). Literature was searched through May 2012. The effect size was calculated as event rates (95% CI), with homogeneity testing using Cochran's Q and I(2) statistics. Meta-regression was used to test the impact of study-level covariates (HPV detection method, geographic origin) on effect size, and potential publication bias was estimated using funnel plot symmetry. Thirty nine studies were eligible, covering 427 ESCPs from different geographic regions. Altogether, 132 (30.9%) cases tested HPV positive; effect size 0.375 (95% CI 0.319-0.434) using the fixed-effects (FE) model and 0.412 (95% CI 0.295-0.540) using the random-effects model. In meta-analysis stratified by (i) HPV detection technique and (ii) geographic study origin, the between-study heterogeneity was not significant (p = 0.071 and p = 0.105, respectively). In meta-regression, HPV detection method (p = 0.260) and geographic origin (p = 0.436) were not significant study-level covariates accounting for the heterogeneity in HPV prevalence. Some evidence for publication bias was found only for PCR-based studies, with a marginal impact on summary effect size estimates. In sensitivity analysis, all meta-analytic results were robust to all one-by-one study removals. In stratified meta-analysis and formal meta-regression, the variability in HPV detection rates in ESCPs is not explained by the HPV detection method or geographic origin of the study.

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“…23 Although it is unknown whether solitary esophageal papillomas are premalignant lesions because of the highly variable clinical course, ESP carries a significant potential of malignant transformation, as squamous cell carcinomas were identified in almost half of the reported cases. 2,4–8,11,28 Thus, early diagnosis and treatment remain imperative.…”

Section: Discussionmentioning

confidence: 99%

Successful Treatment of Extensive Esophageal Squamous Papillomatosis With Cryotherapy

et al. 2019

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Esophageal squamous papilloma is a rare endoscopic finding, and esophageal squamous papillomatosis (ESP) is considered exceptionally rare, with only a limited number of cases reported to date. There is a paucity of literature about the management of these lesions, and it remains largely controversial. We report a 61-year-old man who presented for endoscopic treatment of ESP detected during endoscopic evaluation for heartburn. Given the potential risk of malignant transformation, a decision was made to proceed with spray cryoablation, requiring a total of 3 sessions of ablative therapy. The histopathological assessment confirmed the diagnosis, and the specimens tested negative for all low- and high-risk human papillomavirus subtypes. Follow-up endoscopies revealed near-complete resolution. To our knowledge, the present report describes the second successful treatment of ESP using endoscopic spray cryotherapy.

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Esophageal squamous papillomatosis

Cited by 14 publications

References 12 publications

Esophageal papillomatosis complicated by squamous cell carcinoma

Esophageal papillomatosis complicated by squamous cell carcinoma

Detection of human papillomavirus in esophageal papillomas: systematic review and meta‐analysis

Successful Treatment of Extensive Esophageal Squamous Papillomatosis With Cryotherapy

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