Esophageal papillomatosis complicated by squamous cell carcinoma

Donnellan, Fergal; Walker, Blair; Enns, Robert

doi:10.1055/s-0031-1291599

Cited by 7 publications

(18 citation statements)

References 4 publications

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“…From our findings, we can conclude that SCC prevalence was 1.3 % in this case series. Our data support the fact that ESP may be associated with SCC and should require specific endoscopic survey 18 .…”

Section: Discussionsupporting

confidence: 86%

“…These data are consistent with previous reports 2 5 7 . Endoscopic characteristics of ESP were broadly similar to previous reports: single, small (3 mm), soft, and whitish, located at the distal esophagus 2 5 7 12 18 . ESP shape in our study was different, with more pedicle than sessile lesions 2 5 .…”

Section: Discussionsupporting

confidence: 85%

“…A better knowledge of the natural history is needed to assess the risk of SCC in case of ESP. The malignant potential of ESP has been described in six patients 14 15 16 17 18 19 ( Table 5 ). The first case was reported by Van Cutsem et al in 1992 14 .…”

Section: Discussionmentioning

confidence: 99%

“…The cases concern three females 16 18 19 and three males 14 15 17 . All SCC were developed on an esophageal papillomatosis 14 15 16 17 18 19 . Presence of HPV was negative in two out of three patients 14 16 17 .…”

Section: Discussionmentioning

confidence: 99%

“…ESP is considered a benign neoplasia [12]; however, recent reports highlighted the potential malignant evolution of these lesions 12 14 15 16 17 18 19 . In most of the reported cases, squamous cell carcinoma (SCC) developed on giant ESP or on squamous papillomatosis [14 – 19].…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of esophageal squamous papilloma (ESP) and associated cancer in northeastern France

d’Huart

Chevaux

Bressenot

et al. 2015

EIO

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Background and study aims: Esophageal squamous papilloma (ESP) is a rare lesion. The aims of this study were to assess the prevalence of ESP in northeastern France and the risk of associated squamous cell carcinoma (SCC). Patients and methods: The charts of 78 patients who were diagnosed with ESP between January 2005 and February 2013 at three hospitals in northeastern France were reviewed. Results: A total of 55 305 endoscopies were performed and 78 ESP were diagnosed (0.01 %). Patients with ESP included 44 males (56.4 %), 34 females (43.6 %); median age 50, interquartile range (IQR) 19 – 86. Median follow-up was 21 months (IQR 0 – 91 mo) and median time between first and second endoscopy was 7 months (IQR 0.5 – 74 mo). Of the total number of patients, 35 (44.9 %) had a second endoscopy. Main endoscopy indication was dyspepsia (24.4 %). Most ESP were isolated (93.6 %) and located at distal esophagus (27 cm, IQR 16 – 40 cm). Median size was 3 mm (IQR 1 – 20 mm). ESP-associated endoscopic lesions were hiatal hernia in 12 patients and esophagitis in 11 patients. Endoscopic treatment was mainly excisional biopsies (60.3 %). Human papillomavirus (HPV) was not detected in the 6 patients with available data. Low dysplasia was found in 2 ESP. During follow-up endoscopies, 2 SCC were detected in 2 different patients; the first SCC was located at the previous resection site of the ESP and the second had a different location. Prevalence of associated cancer was 1.3 %. Conclusion: Prevalence of ESP in northeastern France is similar to that previously reported. Endoscopic findings were also broadly the same as in previous reports. The occurrence of dysplasia and SCC should strongly encourage the endoscopist to totally remove the ESP and to start an endoscopic surveillance, given the potential risk of malignant transformation.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Prevalence of esophageal squamous papilloma (ESP) and associated cancer in northeastern France

d’Huart

Chevaux

Bressenot

et al. 2015

EIO

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Esophageal squamous papilloma: Literature review and case–control retrospective study with histopathological exam of human papillomavirus

Ahmad,

Lee,

Nithagon

et al. 2023

JGH Open

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Background and AimEsophageal squamous papilloma (ESP) is a benign growth in the esophagus with unknown malignant potential. The mechanism underlying ESP formation is unknown, but human papillomavirus (HPV) infection has been proposed as a potential etiology. We sought to investigate the clinical characteristic of ESP in our population, review the current literature, and highlight the role of HPV.MethodsThis is a retrospective case–control study conducted at two referral centers. We selected the ESP population by free‐text search in the pathology department database and selected controls randomly from the general endoscopy population. Immunostains were used to evaluate ESP tissue for HPV.ResultsBetween January 2016 and December 2021, we identified 66 patients with ESP, with a prevalence of 0.72%. ESP patients were younger, with a median age of 52 years (P = 0.021), and more likely African American (34.4 vs 7.5%, P < 0.001) compared to controls. On endoscopy images, the growth was predominantly solitary (92.5%) in the middle of the esophagus (39.4%), with sizes ranging from 0.2 to 2.3 cm. A total of 62 patients had available tissue for HPV immune staining, and none tested positive for HPV. Eighteen patients had a follow‐up endoscopy with an average of 504.5 days follow‐up period. One patient developed esophageal squamous cell carcinoma during follow‐up.ConclusionsWe observed a higher prevalence of ESP compared to previous studies. The formation of ESP is multifactorial and partially explained by HPV infection in selected populations. The malignant potential of ESP is low but not negligible.

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