Esophageal Reconstruction with ECM and Muscle Tissue in a Dog Model

Restoring Mucosal Barrier Function and Modifying Macrophage Phenotype with an Extracellular Matrix Hydrogel: Potential Therapy for Ulcerative Colitis

“…Active disease is characterized by chronic inflammation of the colon and defects in intestinal epithelial cell (IEC) barrier function [4]. Based upon observations that bioscaffolds composed of extracellular matrix (ECM) were shown to mitigate inflammation and support functional reconstruction of tissues including the gastrointestinal tract [5,6,7,8], we hypothesized that a similar approach to UC therapy will (1) abate inflammatory flares not by immune suppression but rather by promoting alternative activation of the local immune cell population, and (2) induce rapid restoration of the colonic mucosal barrier function not by simply providing a physical barrier between colonic submucosa and luminal contents but rather by promoting proliferation and replacement of the colonic mucosal epithelium. This two-pronged approach was tested by local delivery (enema) of an ECM hydrogel in a rodent model of UC.…”

Acetylated bacterial cellulose coated with urinary bladder matrix as a substrate for retinal pigment epithelium

“…In fact, BC has shown to be an interesting and versatile biomaterial, particularly in tissueengineered applications (tissue scaffolds and drug delivery systems) for the regeneration of damaged or diseased tissues and organs [19][20][21]. Also, UBM has been widely studied in several pre-clinical studies as a biologic scaffold for the reconstruction of damaged tissues [22][23][24][25][26][27][28].…”

The chondrogenic differentiation of mesenchymal stem cells on an extracellular matrix scaffold derived from porcine chondrocytes

“…Recently, many studies have been reported on scaffolds fabricated with extracellular matrix (ECM) materials derived from cells or tissues by themselves [5,6]. In addition to supporting the structural integrity of engineered tissues, ECM materials can have diverse physiological functions by acting as a reservoir of cytokines and growth factors, transmitting specific signals through interactions with cell surface receptors, and providing specific microenvironments similar to natural tissues [7,8].…”