Esophageal manometry and ambulatory 24-hour pH monitoring in patients with short and long segment Barrett's esophagus

Abstract

As a group, SSBE patients have more competent LES sphincters and less gastroesophageal reflux at 0 and 5 cm above the LES as compared with patients with LSBE. These data indicate that the degree and length of acid exposure in the esophagus are important factors in the pathogenesis of SIM involvement of the esophagus.

Esophageal manometry findings and degree of acid exposure in short and long Barrett's esophagus

“…The average age is in the fifties, with no statistical difference between groups. Several other studies confirm these findings (1,4,5,10,11,12) and present a profile of patients who are Caucasian men mainly, over 50 with longstanding heartburn (20) . The mean age similarity between the two groups is one of the arguments against the possibility of progression in the length of Barrett's mucosa.…”

“…The mean age similarity between the two groups is one of the arguments against the possibility of progression in the length of Barrett's mucosa. If there were such a progression, the SSBE group would be younger than the LSBE group, thus, there must be other mechanisms at work in the development of Barrett's metaplasia (10) . As this was a retrospective study, information about symptom onset time, which would characterize the duration of the disease, could not be obtained for all patients, but there was no statistical difference between groups.…”

“…The main factors are chronic and prolonged acid and/or bile reflux. When compared to controls, BE patients present more pronounced motor abnormalities such as severe LES hypotension and esophageal body hypomotility (10,11,12) . The aim of this study was to compare SSBE and LSBE with regard to demographic and esophageal manometriy characteristics and esophageal pH monitoring.…”

Barrett's Esophagus and Severe Reflux Esophagitis Share Common Pathophysiological Characteristics among Chinese in Taiwan

“…The degree and length of acid exposure in the esophagus are important factors in the pathogenesis of specialized intestinal metaplasia of the esophagus (12). Intestinal metaplasia develops when GERD damages the squamous esophageal mucosa and the injury heals through a metaplastic process in which columnar cells replace squamous cells (13).…”

“…These results showed significantly longer and more frequent acid reflux in both groups, but they did not explain the causes leading to BE formation. In studies (12,28,29) T a b l e 3 . Da t a o f E s o p h a g e a l 2 4 -h o u r p H Mo n i t o r i n g o f P a t i e n t s (30,31).…”