Esophageal Gastrointestinal Stromal Tumors Presenting as Mediastinal Mass

Kafeel, Muhammad I.; Cheedella, Naga; Wang, J. C.

doi:10.1159/000356998

Cited by 11 publications

(3 citation statements)

References 19 publications

(15 reference statements)

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“…There is currently 1 case by M. Kafeel et al wherein a GIST was initially diagnosed as an LMS; in this case, immunohistochemical staining for KIT was not performed. 6 The distinction between LMS and GIST is important in guiding clinical decisionmaking; although resection is often definitive treatment in both GIST and LMS, the first-line treatments in metastasized GIST and LMS are, respectively, the tyrosine kinase receptor inhibitor imatinib and gemcitabine-docetaxel. 7,8 Our case is unique, given that the diagnosis of GIST was made based on positive immunohistochemical staining for CD117 and DOG1 of a EUS-guided FNA.…”

Section: Discussionmentioning

confidence: 99%

A Curious Case of a Posterior Mediastinal Mass

et al. 2021

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Gastrointestinal stromal cell tumors (GISTs) are mesenchymal stromal tumors that are characteristically CD117 positive. Distinction from other spindle cell tumors such as leiomyomas and leiomyosarcomas is based on clinical, histological, and molecular features. Endoscopic ultrasonography-guided fine-needle aspiration has become a highly used means of preoperative identification of GIST, especially if immunohistochemical staining for CD117 can be performed. We present a case of a posterior mediastinal mass diagnosed as GIST after being found to be CD117 positive, later found to be a metastatic leiomyosarcoma.

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Section: Discussionmentioning

confidence: 99%

A Curious Case of a Posterior Mediastinal Mass

et al. 2021

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“… 2 , 3 Esophageal GISTs (E-GISTs) are extremely rarer, accounting for not more than 1–2% of all GISTs. 4 …”

Section: Introductionmentioning

confidence: 99%

Endoscopic resection for esophageal gastrointestinal stromal tumors: a multi-center feasibility study

Lian,

Ji,

Chen

et al. 2024

Therap Adv Gastroenterol

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Background: Esophageal gastrointestinal stromal tumors (E-GISTs) are highly uncommon and have not been thoroughly examined. Objectives: The objective of this multi-center study was to assess the viability of endoscopic resection (ER) in the treatment of E-GISTs and to explore its clinical implications. Design: This was a multi-center retrospective study. Consecutive patients referred to the four participating centers. Methods: E-GISTs among the consecutive subepithelial tumors (SETs) treated by ER methods were enrolled from April 2019 to August 2022. Clinicopathological, endoscopic, and follow-up data were collected and analyzed. Results: A total of 23 patients with E-GISTs were included for analysis, accounting for 1.9% of all the esophageal SETs (1243 patients). The average size of the tumor lesions was 2.3 cm (range 1.0–4.0 cm). We observed that tumors larger than 2.0 cm were more likely to grow deeper, with a statistically significant difference ( p < 0.001). End bloc resection was achieved in all 23 patients. The mean operation time was 53.6 min (range 25–111 min). One patient experienced significant intraoperative bleeding, which was promptly managed endoscopically without necessitating surgery. The average hospital stay was 4.5 days (range 3–8 days). The overall median follow-up period was 31 months (range 13–47 months). No tumor recurrence, residual tumor, distal metastasis, or death was observed during the follow-up period. Conclusion: Based on our limited data, our study indicates that ER may be a feasible and effective option for treating esophageal GISTs measuring 4 cm or less. We suggest submucosal tunnel endoscopic resection as the preferred approach, as all E-GISTs in our study were situated in the muscularis propria layer. Additionally, tumors larger than 2 cm were more prone to deeper growth or extraluminal extension.

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“…El tamaño de estos tumores es, en promedio, de 5 a 10 cm en su mayor eje, pero se han reportado casos de tumores gigantes en el esófago, por lo que, a pesar de ser poco frecuentes, deben considerarse dentro del diagnóstico diferencial de las masas mediastinales [7][8][9] .…”

Section: Introductionunclassified

Reemplazo total esofágico mediante ascenso gástrico transmediastinal en tumor del estroma gastrointestinal esofágico: reporte de un caso quirúrgico raro

Morales-Maza¹,

Cisneros-Correa²,

Angel-Millán³

et al. 2019

CIRU

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ResumenAntecedentes: Los tumores del estroma gastrointestinal (GIST) son las lesiones malignas mesenquimales más comunes del tracto digestivo. Un sitio raro de localización de estos tumores es el esófago. A la fecha actual no hay un consenso claro basado en evidencia científica con respecto al tipo de cirugía a realizar en pacientes con GIST en esta localización inusual. Caso clínico: Una mujer previamente sana presentó disfagia, pérdida de peso (6 kg) y malestar general. La tomografía computarizada reveló un engrosamiento del esófago y en la ultrasonografía endoscópica se observó una lesión localizada en el esófago dependiente de la muscular propia. Se optó por realizar esofagectomía con reemplazo mediante transposición transmediastinal del estómago. La paciente se recuperó bien de la cirugía y fue dada de alta en condición estable en el séptimo día del posoperatorio. A los 6 meses, se encuentra asintomática. Conclusión: Este caso ilustra la presentación clínica de un GIST esofágico que representa solo el 1% de todos los sitios reportados. La cirugía se realizó con éxito, con morbilidad mínima, resolución completa de los síntomas y mejoría de la calidad de vida de la paciente. La esofagectomía con reemplazo mediante transposición transmediastinal del estómago (comúnmente llamado ascenso gástrico) debe realizarse cuando el centro tiene experiencia para hacerlo con morbilidad y mortalidad mínimas.

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Esophageal Gastrointestinal Stromal Tumors Presenting as Mediastinal Mass

Cited by 11 publications

References 19 publications

A Curious Case of a Posterior Mediastinal Mass

A Curious Case of a Posterior Mediastinal Mass

Endoscopic resection for esophageal gastrointestinal stromal tumors: a multi-center feasibility study

Reemplazo total esofágico mediante ascenso gástrico transmediastinal en tumor del estroma gastrointestinal esofágico: reporte de un caso quirúrgico raro

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