Esophageal function worsens with long duration of diabetes

Kinekawa, Fumihiko; Kubo, Fumiyoshi; Matsuda, Kazuya; Kobayashi, Mitsuyoshi; Furuta, Yasuo; Fujita, Yöko; Okada, Hiroki; Muraoka, Tomie; Yamanouchi, Hideo; Inoue, Hirokazu; Uchida, Yuzo; Masaki, Tsutomu

doi:10.1007/s00535-008-2169-6

Cited by 37 publications

(28 citation statements)

References 41 publications

(74 reference statements)

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“…Several studies showed that disease duration of diabetes [117,120] and the presence of diabetic neuropathy [119,120] were associated with GERD. Because esophageal motility disorder and abnormal acid reflux in diabetic patients are associated with diabetic motor neuropathy [122] and such esophageal dysfunction is worsened with long disease duration [123], esophageal dysfunction may result in a higher prevalence of GERD in diabetic patients.…”

Section: Diabetes Mellitusmentioning

confidence: 99%

Epidemiology and clinical characteristics of GERD in the Japanese population

2009

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We reviewed articles on the epidemiology and clinical characteristics of gastroesophageal reflux disease (GERD) in Japan to clarify these features of GERD in this country. Although the definition of GERD depends on the individual study, the prevalence of GERD has been increasing since the end of the 1990s. The reasons for the increase in the prevalence of GERD may be due to increases in gastric acid secretion, a decrease in the Helicobacter pylori infection rate, more attention being paid to GERD, and advances in the concept of GERD. More than half of GERD patients had non-erosive reflux disease, and the majority (87%) of erosive esophagitis was mild type, such as Los Angeles classification grade A and grade B. There were several identified risk factors, such as older age, obesity, and hiatal hernia. In particular, mild gastric atrophy and absence of H. pylori infection influence the characteristics of GERD in the Japanese population. We also discuss GERD in the elderly; asymptomatic GERD; the natural history of GERD; and associations between GERD and peptic ulcer disease and H. pylori eradication. We examined the prevalence of GERD in patients with specific diseases, and found a higher prevalence of GERD, compared with that in the general population, in patients with diabetes mellitus, those with obstructive sleep apnea syndrome, and those with bronchial asthma. We provide a comprehensive review of GERD in the Japanese population and raise several clinical issues.

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Section: Diabetes Mellitusmentioning

confidence: 99%

Epidemiology and clinical characteristics of GERD in the Japanese population

2009

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“…This was relevant with others' findings which showed GERD was more prevalent in DM patients than non-DM patients. 4,13,14 Nonetheless, GERD in this study was less prevalent than GERD in DM patients in United States (40.8% in DM population vs 18.1-27.8% in its general population). 15,29 It might be caused by higher mean BMI in that study (32 ± 7.2 kg/m 2 ) 15 than the BMI in our study (24.07 ± 4.32 kg/m 2 ), resulting in worse GERD symptoms attributable to the co-morbidity.…”

Section: Discussionmentioning

confidence: 46%

“…4,[12][13][14][15] Studies conducted in various countries have shown that GERD was a frequent complication in approximately 23-29% of DM patients and reached up to half of total diabetes cases in New Jersey, United States. [15][16][17][18][19][20] Another complexity of DM in the case of GERD is that DM will give poor prognostic effect to the latter since: (1) DM will reduce the effectiveness of acid-suppression therapy, which is the mainstay therapy of GERD 21 and; (2) DM increases the occurrence of Barrett's esophagus and esophageal cancer.…”

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confidence: 99%

Gastro-esophageal reflux disease among type-2 diabetes mellitus patients in a rural area

et al. 2015

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ABSTRAK p = 0,048). Adapun lama DM,[2][3][4][5][6][7][8][9][10][11][12][13] p = 0,976), obesitas (37% vs 38%, p = 0,897), usia (53,2 ± 10,5 vs 54,7 ± 9,3, p = 0,481) ABSTRACTBackground: One of the most neglected complications of diabetes mellitus (DM) is gastro-esophageal reflux disease (GERD) which arises from autonomic neuropathy and diabetic gastropathy related to the extent of DM. This study was done to find prevalence of GERD in DM patients with GERD-questionnaire (GERDQ), dietary factor proportion, and their association with other GERD risk factor in rural area.Methods: This cross sectional study was conducted in Puskesmas Pelaihari from August to September 2013. Subjects with DM aged ≥ 18 were selected consecutively from both newly and previously diagnosed patients with exclusion criteria: pregnancy, in proton-pump inhibitor therapy, and had other metabolic disease(s). DM was diagnosed with ADA criteria, while GERD was diagnosed in patients with score of ≥ 8 of Indonesian GERDQ.Results: There were 30 subjects (29.7%) with GERD among 101 patients with DM and dietary factors found in GERD patients were spicy diet (90%), high-fat food (90%), irritative beverages (87%), and irritative diet (23%). Only female gender was associated with GERD vs non-GERD in DM patients (87% vs 68%, p = 0.048). Meanwhile, duration of DM (2 [0-13] vs 2 [0-19], p = 0.976), obesity (37% vs 38%, p = 0.897), age (53.2±10.5 vs 54.7 ± 9.3, p = 0.481), and uncontrolled diabetes (90% vs 94%, p = 0.421) were not associated with the GERD among DM patients. Conclusion:Prevalence of GERD in DM is somewhat high in this study. Female group with DM needs to be screened for GERD as early as possible.

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“…Thank you very much for your valuable comments on our article 1 . Autonomic neuropathy is a common complication of diabetes mellitus.…”

Section: Authors' Replymentioning

confidence: 99%