Esmolol Hydrochloride for Management of the Cardiovascular Stress Responses to Laryngoscopy and Tracheal Intubation

Vucevic, M.; Purdy, Graeme M.; Ellis, F. R.

doi:10.1093/bja/68.5.529

Cited by 82 publications

(53 citation statements)

References 5 publications

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“…Although previous studies have also shown that esmolol blunted the hypertension and tachycardia associated with several perioperative pain stimuli, including intubation, [17][18][19][20] emergence and extubation, 2 1 Mean arterial blood pressure changes following saline (n=9), esmolol low (n=7) and esmolol high (n=9) in rats subjected to formalin injection. Data are expressed as actual changes from ST (mean ± SEM).…”

Section: Discussionmentioning

confidence: 88%

Antinociceptive and cardiovascular properties of esmolol following formalin injection in rats

Davidson¹,

Doursout²,

Szmuk³

et al. 2001

Can J Anesth/J Can Anesth

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Section: Discussionmentioning

confidence: 88%

Antinociceptive and cardiovascular properties of esmolol following formalin injection in rats

Davidson¹,

Doursout²,

Szmuk³

et al. 2001

Can J Anesth/J Can Anesth

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“…Several investigators have also documented that it controls hemodynamic changes in clinical situations. [4][5][6] Another ultra-short acting beta blocker, landiolol…”

Section: Laboratory Investigationsmentioning

confidence: 99%

Modifications of the hemodynamic consequences of theophylline intoxication with landiolol in halothane-anesthetized dogs

Takahashi

Fujii

Hoshi

et al. 2000

Can J Anesth/J Can Anesth

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Purpose: To examine the effect of landiolol (ONO-1101), a new ultra-short acting, highly selective beta 1 blocker, on hemodynamic response to acute theophylline intoxication in anesthetized dogs.Methods: Thirty-four dogs were studied during halothane anesthesia. Aminophylline (50 mg·kg -1 over 20 min followed by infusion at 1.75 mg·kg -1 ·hr -1 ) was administered as a model of acute theophylline intoxication. Dogs were randomly enrolled into four landiolol groups (0, 1, 10, 100 µg·kg -1 ·min -1 ) to treat tachyarrhythmias. Hemodynamic variables, heart rate (HR), systemic blood pressure (SBP), pulmonary artery pressure, pulmonary artery occlusion pressure, and cardiac output (CO) were measured along with plasma concentrations of theophylline, epinephrine, and norepinephrine. Results: After 60 min, plasma concentration of theophylline reached 46.6 ± 4.0 (mean ± SD) µg·ml -1 , HR increased from 129 ± 21 to 193 ± 27 bpm (P < 0.0001) and CO increased from 1.6 ± 0.5 l·min -1 to 2.1 ± 0.4 l·min -1 (P < 0.0001), whereas SBP decreased from 139 ± 25 to 121 ± 25 mm Hg (P < 0.0001), with decreasing systemic vascular resistance. After intoxication, plasma epinephrine concentration increased from 125 ± 112 to 325 ± 239 pg·ml -1 (P < 0.0001), and norepinephrine concentration from 103 ± 61 to 133 ± 61 pg·ml -1 (P < 0.0011). Landiolol 10 µg·kg -1 ·min -1 decreased HR to pre-intoxication level, whereas HR returned to the intoxication baseline by 30 min after cessation of landiolol infusion. Conclusions: Landiolol controlled tachyarrhythmias associated with theophylline toxicity. The optimal effective dose of landiolol was 10 µg·kg -1 ·min -1 .Objectif : Examiner l'effet du landiolol (ONO-1101), nouveau bloqueur beta 1 hypersélectif à action ultrabrève, sur la réponse hémodynamique de l'intoxication aiguë à la théophylline chez des chiens anesthésiés. Méthode : L'étude a porté sur 34 chiens anesthésiés à l'halothane. L'aminophylline (50 mg·kg -1 pendant 20 min, suivi d'une perfusion à 1,75 mg·kg -1 ·hr -1 ) a été administrée pour provoquer l'intoxication aiguë à la théophylline. Les chiens, répartis au hasard en quatre groupes, ont reçu différentes doses de landiolol (0, 1, 10, 100 µg·kg -1 ·min -1 ) pour traiter la tachyarythmie. On a mesuré : la fréquence cardiaque (FC), la pression sanguine systémique (PSS), la pression artérielle pulmonaire, la pression artérielle pulmonaire bloquée et le débit cardiaque (DC) de même que les concentrations plasmatiques de théophylline, d'épinéphrine et de norépinéphrine. Résultats : Après 60 min, la concentration plasmatique de théophylline était de 46,6 ± 4,0 (moyenne ± écart type) µg·ml -1 , la FC avait augmenté de 129 ± 21 à 193 ± 27 bpm (P < 0,0001) et le DC était passée de 1,6 ± 0,5 l·min -1 à 2,1 ± 0,4 l·min -1 (P < 0,0001), tandis que la PSG avait baissé de 139 ± 25 à 121 ± 25 mm Hg (P < 0,0001) et que la résistance vasculaire générale diminuait. Après l'intoxication, la concentration plasmatique d'épinéphrine a augmenté de 125 ± 112 à 325 ± 239 pg·ml -1 (P < 0,0001), et la concentratio...

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“…Recent knock-out mouse studies suggested that specific beta 1 -adrenergic receptor blockade, and not beta 2 Each value is mean ± SD. a = obtained just before treatment; b = obtained 30 min after saline or milrinone treatment; SBP = systolic blood pressure; MBP = mean blood pressure; DBP = diastolic blood pressure; HR = heart rate; CVP = central venous pressure; MPAP = mean pulmonary artery pressure; PAOP = pulmonary artery occlusion pressure; CO = cardiac output; SVR = systemic vascular resistance; PVR = pulmonary vascular resistance.…”

Section: Me Et Th Ho Od Ds Smentioning

confidence: 99%

“…1 ETA-ADRENERGIC receptor blockers have been used widely in the treatment of tachycardia and dysrhythmias. 1,2 Recent reports [3][4][5][6] demonstrated that the prophylactic administration of beta-adrenergic blockers in patients with ischemic heart disease reduced the incidence of postoperative ischemic events and reduced mortality.…”

mentioning

confidence: 99%

Milrinone attenuates the negative inotropic effects of landiolol in halothane-anesthetized dogs

Takahashi

Fujii

Hoshi

et al. 2003

Can J Anesth/J Can Anesth

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B Ba ac ck kg gr ro ou un nd d: : Clinical use of high dose beta-blocker therapy is limited by excessive negative inotropic effects. Previous studies suggest that milrinone may be of utility in limiting the inotropic but not the chronotropic effects of beta blockers. We examined the hemodynamic effects of co-administration of a new potent selective beta 1 blocker, landiolol, and milrinone in halothane-anesthetized dogs.M Me et th ho od ds s: : Eighteen adult mongrel dogs were anesthetized with 1.2 MAC halothane. Hemodynamic measurements were made at baseline, 30 min after starting the milrinone (0.5 µg·kg -1 ·min -1 ) or normal saline infusion (n = 9 in each), then 30 min after each change in the dose of landiolol infusion. The tested doses of landiolol were 10, 100, and 1000 µg·kg -1 ·min -1 .

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Esmolol Hydrochloride for Management of the Cardiovascular Stress Responses to Laryngoscopy and Tracheal Intubation

Cited by 82 publications

References 5 publications

Antinociceptive and cardiovascular properties of esmolol following formalin injection in rats

Antinociceptive and cardiovascular properties of esmolol following formalin injection in rats

Modifications of the hemodynamic consequences of theophylline intoxication with landiolol in halothane-anesthetized dogs

Milrinone attenuates the negative inotropic effects of landiolol in halothane-anesthetized dogs

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