ESKAPE bacteria characterization reveals the presence of Acinetobacter baumannii and Pseudomonas aeruginosa outbreaks in COVID-19/VAP patients

Loyola-Cruz, Miguel Ángel; Durán-Manuel, Emilio Mariano; Cruz-Cruz, Clemente; Marquez-Valdelamar, Laura Margarita; Bravata-Alcantará, Juan Carlos; Cortés-Ortíz, Iliana Alejandra; Cureño-Díaz, Mónica Alethia; Ibáñez-Cervantes, Gabriela; Fernández-Sánchez, Verónica; Castro-Escarpulli, Graciela; Bello–López, Juan Manuel

doi:10.1016/j.ajic.2022.08.012

Cited by 12 publications

(12 citation statements)

References 57 publications

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“…Tal fenômeno foi demostrado em uma análise que apresentou alta prevalência de isolados pertencentes ao grupo ESKAPE (63,85%) entre as coinfecções bacterianas detectadas. Dentre os patógenos, foram detectados a dispersão dos clones de A. baumannii com desfechos fatais (Loyola, et al, 2022).…”

Section: Discussionunclassified

Infecções secundárias causadas por bactérias do grupo ESKAPE e impacto à saúde de pacientes com complicações da Covid-19 – uma revisão integrativa

Ribeiro

Torres

Rodrigues

et al. 2022

RSD

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Introdução: A resistência bacteriana descrita para o grupo ESKAPE é uma problemática considerável para a saúde global que resulta em prejuízos sociais, econômicos e principalmente a saúde. Objetivos: Descrever os prejuízos associados à saúde de pacientes internados com complicações da COVID-19 inerentes as coinfecções causadas pelo grupo bacteriano ESKAPE. Metodologia: Trata-se de uma revisão integrativa da literatura, as buscas dos estudos foram realizadas nas bases National Library of Medicine National Institutes of Health (PubMed) e Science Direct, utilizando o método PRISMA, foram incluídos artigos publicados entre os anos de 2020 e 2021, em inglês. Resultados: A amostra contou com 17 artigos, nos quais detectou-se a ocorrência do grupo ESKAPE e prejuízos inerentes à saúde dos pacientes com COVID-19. O Staphylococcus aureus sensível à meticilina (MSSA), seguido pelo Staphylococcus aureus resistente à meticilina (MRSA), Klebsiella pneumoniae e Enterococcus spp. foram as principais bactérias relatadas. Os principais prejuízos inerentes a associação COVID-ESKAPE foram o tempo prolongado de internação, a resistência bacteriana aos antimicrobianos e pior prognóstico. Conclusão: Portanto, a associação entre a presença de bactérias do grupo ESKAPE e os prejuízos inerentes à saúde de pacientes com COVID-19 não podem ser subestimadas. Faz-se necessário dar seguimento com novos estudos, a fim de prevenir agravos e promover saúde com base nas informações sobre as principais complicações, promovendo intervenções e reduzindo a morbimortalidade desses pacientes.

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Section: Discussionunclassified

Infecções secundárias causadas por bactérias do grupo ESKAPE e impacto à saúde de pacientes com complicações da Covid-19 – uma revisão integrativa

Ribeiro

Torres

Rodrigues

et al. 2022

RSD

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“…Members of these bacterial groups have been detected on inert surfaces, on the hands of healthcare personnel, and it has been shown that this was directly related to the incidence of HAIs in critically ill patients in this pandemic [ 33 , 34 ]. It is speculated that the frequently reported antimicrobial resistance in this group of microorganisms had a direct impact on the clinical status of patients with SARS-CoV-2 infection, length of hospital stay, morbidity, and mortality [ 35 , 36 ].…”

Section: Eskape and Enterobacterales In The Covid Eramentioning

confidence: 99%

ESKAPE and Beyond: The Burden of Coinfections in the COVID-19 Pandemic

et al. 2023

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The ESKAPE group constitute a threat to public health, since these microorganisms are associated with severe infections in hospitals and have a direct relationship with high mortality rates. The presence of these bacteria in hospitals had a direct impact on the incidence of healthcare-associated coinfections in the SARS-CoV-2 pandemic. In recent years, these pathogens have shown resistance to multiple antibiotic families. The presence of high-risk clones within this group of bacteria contributes to the spread of resistance mechanisms worldwide. In the pandemic, these pathogens were implicated in coinfections in severely ill COVID-19 patients. The aim of this review is to describe the main microorganisms of the ESKAPE group involved in coinfections in COVID-19 patients, addressing mainly antimicrobial resistance mechanisms, epidemiology, and high-risk clones.

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“…Pseudomonas aeruginosa is an opportunistic and nosocomial pathogen that colonizes people with cystic fibrosis and is a common etiologic agent of bacteremia, urinary tract infections, wound infections, and colonizes people with cystic fibrosis, among other infections. Recently, it has been described as a pathogen that coinfects patients with COVID-19 [1,2]. Despite the advances made through the introduction of antipseudomonal drugs, Pseudomonas aeruginosa infections remain a big threat in patients due to its resistance to antibiotics.…”

Section: Introductionmentioning

confidence: 99%

Molecular Characterization of Carbapenemase Encoding Genes in Pseudomonas aeruginosa from Tertiary Healthcare in South Eastern Nigeria

Ogba

Nomeh

Edemekong³

et al. 2022

AJBGMB

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Background and Objectives: In recent years, the rate of carbapenemase encoding gene in P. aeruginosa has increased worldwide and has become of great concern since it’s significantly restricts the therapeutic options for patients in Tertiary health care. Therefore, there’s a need for molecular characterization of carbapenemase encoding genes in Pseudomonas aeruginosa from Tertiary Healthcare in South Eastern Nigeria. Methodology: A total of twelve (12) Pseudomonas aeruginosa positive culture of Urine (n=5), Wound swab (n=5), Catheter tip (n=2) were collected from Alex Ekwueme Federal University Hospital Teaching Hospital, Abakaliki (AE-FUTHA), Ebonyi State, South eastern Nigeria. The Pseudomonas aeruginosa strain confirmation was performed using VITEK 2 System and the bacteria were further screen for carbapemase encoding gene by PCR specific primer. Results: Molecular amplification of carbapenemase encoding genes revealed that blaNDM and blaIPM accounted 12 (100%) across all sample source. Among the various sample sources, blaKPC was found 1(8.3%) in Urine, wound swab 3(25.0%), and Catheter tip 1(8.3%), while blaVIM was found 2(16.7%), 2(16.7%) and 0(0.0%) in Urine, wound swab and Catheter tip respectively. Co-expression of blaNDM + blaIMP accounted 5(41.6 %), 5(41.6 %) and 2(16.7 %) in Urine, wound swab and Catheter tip respectively. Co-expression of blaKPC + blaNDM + blaVIM + blaIMP + blaOXA was only detected in urine 1(8.3 %). Conclusion: The current study gives an account of the presence of carbapenemase-encoding genes in P. aeruginosa. The expression of carbapenemase-encoding genes may be the mainstay of phenotypic MDR. As a result, physicians, other medical professionals, researchers, and public health policymakers must be kept up to date on the spread of carbapenemase-encoding genes. In addition, strict infection prevention and control strategies, as well as antimicrobial stewardship programs, are highly desirable in admission healthcare facilities where carbapenemase-encoding genes are spreading.

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ESKAPE bacteria characterization reveals the presence of Acinetobacter baumannii and Pseudomonas aeruginosa outbreaks in COVID-19/VAP patients

Cited by 12 publications

References 57 publications

Infecções secundárias causadas por bactérias do grupo ESKAPE e impacto à saúde de pacientes com complicações da Covid-19 – uma revisão integrativa

Infecções secundárias causadas por bactérias do grupo ESKAPE e impacto à saúde de pacientes com complicações da Covid-19 – uma revisão integrativa

ESKAPE and Beyond: The Burden of Coinfections in the COVID-19 Pandemic

Molecular Characterization of Carbapenemase Encoding Genes in Pseudomonas aeruginosa from Tertiary Healthcare in South Eastern Nigeria

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