Escherichia coli prosthetic valve endocarditis from a non-genitourinary source

Quiring, Robert; Burke, Victoria E.

doi:10.1016/j.idcr.2021.e01329

Cited by 2 publications

(4 citation statements)

References 11 publications

(33 reference statements)

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“…Thus, it is imperative to ensure prompt diagnosis and timely interventions to prevent complications. Over the last four decades, 34 cases of E. coli IE have been reported in the PubMed database [ 9 , 10 ], and only 10 of them (Table 3 ) were associated with a prosthetic valve (PV) [ 10 - 14 ]. Hence, this is the 11th report of this rare condition.…”

Section: Discussionmentioning

confidence: 99%

“…The risk factors associated with E. coli IE include female sex, age greater than 70, previous healthcare exposure, implanted endovascular devices, diabetes mellitus, a genitourinary source of infection, and immunosuppressive therapy [ 2 , 3 , 6 ]. Of the 10 cases of E. coli PVE previously reported, the mitral valve was the most affected (60%) [ 10 ]. Our patient possessed several characteristics for developing E. coli IE, including a mechanical mitral valve, age, female sex, uncontrolled diabetes mellitus, previous hospitalizations, and recurrent UTIs.…”

Section: Discussionmentioning

confidence: 99%

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Escherichia coli: A Rare Cause of Prosthetic Valve Endocarditis

Peralta¹,

Chang²

2023

Cureus

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Prosthetic valve endocarditis (PVE) is a complication of valve replacement associated with high morbidity and mortality. Escherichia coli ( E. coli ) is rarely associated with infective endocarditis (IE), accounting for less than 1% of the cases reported. The low frequency is attributed to the organism’s low affinity to adhere to the endocardial endothelium. Risk factors that may play a role in developing IE by E. coli include age above 70, diabetes mellitus, a genitourinary source of infection, female sex, healthcare contact, implanted endovascular devices, and immunosuppression. We present a 70-year-old Hispanic woman who arrived with constitutional symptoms and persistent urinary complaints. She had diabetes mellitus, recurrent urinary tract infections, and native mitral valve IE treated with antibiotic therapy and tissue valve replacement. The valve was replaced with a mechanical valve a second time due to malfunctioning. The patient was found to have E. coli bacteremia and ultimately diagnosed with PVE. She was treated solely with ceftriaxone and gentamicin combination therapy resulting in complete resolution of valve vegetations. Our case represents the 11th report of this uncommon disease and illustrates its epidemiology and associated risk factors. We summarize the previous 10 cases reported and highlight the lack of prospective trial data to define optimal therapy for managing PVE caused by E. coli .

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Escherichia coli: A Rare Cause of Prosthetic Valve Endocarditis

Peralta¹,

Chang²

2023

Cureus

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“…(e.g . S. aureus ) Oligopeptides, thiolactone, PlcR, Npr, and PapR (autoinducing peptides) [166,167, 168] Endocarditis (Fernández Guerrero et al 2007 ; Guerrero et al 2009 ; Thomas et al 2012 ; Ferrand et al 2013 ; Lamond et al 2021 ); myocarditis (McGee et al 2018 ; Strnadel et al 2018 ) Gram-negative bacteria Escherichia coli Autoinducer (AI)-3 (Zhou et al 2016 ) Endocarditis (Quiring and Burke 2021 ) Stenotrophomonas Maltophilia (Xanthomonas maltophilia and Pseudomonas maltophilia), X. campestris Homologue of farnesoic acid: cis-11-methyl-2-dodecenoic acid, α,β unsaturated fatty acid (diffusible signal factor, DSF) [178,179] Endocarditis (Mehta et al 2000 ) Acinetobacter sp . (A. baumannii), Aeromonas hydrophyla, Pseudomonas sp ., Serratia marcescens, and Yersinia sp .…”

Section: Emerging Role Of Cardiac Bitter Taste Receptors In Cardiac I...mentioning

confidence: 99%

“…(A. baumannii), Aeromonas hydrophyla, Pseudomonas sp ., Serratia marcescens, and Yersinia sp . N-acyl-L-homoserine lactone, N-(3-oxoacyl)-L-homoserine lactone, N-(3-hydroxyacyl)-L-homoserine lactone; AI-1 (Deep et al 2011 ; Zhou et al 2016 ) Endocarditis (Suri et al 1971 ; Rodríguez-Hernández et al 2004 ; Pugliese et al 2016 ; Gürtler et al 2019 ; Ioannou et al 2021 ), myocarditis (Del-Pozo et al 2011 ; Ranjani et al 2015 ) Pseudomonas aeruginosa Butyryl-homoserine lactone; AI-1(Deep et al 2011 ; Zhou et al 2016 ) Endocarditis (Gürtler et al 2019 ), myocarditis (Ranjani et al 2015 ) Escherichia coli Furanosyl borate diester (AI-2) (Li et al 2007 ; Zhou et al 2016 ) Endocarditis (Quiring and Burke 2021 ) Escherichia coli , Salmonella enterica, and Shigella flexneri 2-Methy-2,3,3,4-tetrahydroxytetrahydrofuran (AI-2) (Li et al 2007 ; Zhou et al 2016 ) Endocarditis (Fernández Guerrero et al 2004 ; Quiring and Burke 2021 ), pericarditis (Fernández Guerrero et al 2004 ), myocarditis (Chehab et al 2020 ), pancarditis (Guerrero Ortiz et al 2003 ) Pseudomonas aeruginosa 2-heptyl-3-hydroxy-4 quinolone, 3-oxododecanoyl-l-homoserine lactone (Rennemeier et al 2009 ) Vide supra Neisseria gonorrhoeae NgAI-2 (AI) (Anderson et al 2016 ; Edwards et al 2016 ) Endocarditis (Olayemi et al 2017 ) …”

Section: Emerging Role Of Cardiac Bitter Taste Receptors In Cardiac I...mentioning

confidence: 99%

Cellular mechanisms and molecular pathways linking bitter taste receptor signalling to cardiac inflammation, oxidative stress, arrhythmia and contractile dysfunction in heart diseases

2022

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Heart diseases and related complications constitute a leading cause of death and socioeconomic threat worldwide. Despite intense efforts and research on the pathogenetic mechanisms of these diseases, the underlying cellular and molecular mechanisms are yet to be completely understood. Several lines of evidence indicate a critical role of inflammatory and oxidative stress responses in the development and progression of heart diseases. Nevertheless, the molecular machinery that drives cardiac inflammation and oxidative stress is not completely known. Recent data suggest an important role of cardiac bitter taste receptors (TAS2Rs) in the pathogenetic mechanism of heart diseases. Independent groups of researchers have demonstrated a central role of TAS2Rs in mediating inflammatory, oxidative stress responses, autophagy, impulse generation/propagation and contractile activities in the heart, suggesting that dysfunctional TAS2R signalling may predispose to cardiac inflammatory and oxidative stress disorders, characterised by contractile dysfunction and arrhythmia. Moreover, cardiac TAS2Rs act as gateway surveillance units that monitor and detect toxigenic or pathogenic molecules, including microbial components, and initiate responses that ultimately culminate in protection of the host against the aggression. Unfortunately, however, the molecular mechanisms that link TAS2R sensing of the cardiac milieu to inflammatory and oxidative stress responses are not clearly known. Therefore, we sought to review the possible role of TAS2R signalling in the pathophysiology of cardiac inflammation, oxidative stress, arrhythmia and contractile dysfunction in heart diseases. Potential therapeutic significance of targeting TAS2R or its downstream signalling molecules in cardiac inflammation, oxidative stress, arrhythmia and contractile dysfunction is also discussed.

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Escherichia coli prosthetic valve endocarditis from a non-genitourinary source

Cited by 2 publications

References 11 publications

Escherichia coli: A Rare Cause of Prosthetic Valve Endocarditis

Escherichia coli: A Rare Cause of Prosthetic Valve Endocarditis

Cellular mechanisms and molecular pathways linking bitter taste receptor signalling to cardiac inflammation, oxidative stress, arrhythmia and contractile dysfunction in heart diseases

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