Cellular mechanisms and molecular pathways linking bitter taste receptor signalling to cardiac inflammation, oxidative stress, arrhythmia and contractile dysfunction in heart diseases

Welcome, M. Osain; Dogo, D; Mastorakis, Nikos E.

doi:10.1007/s10787-022-01086-9

Cited by 8 publications

(6 citation statements)

References 418 publications

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“… 17 Inflammation, oxidative stress, and hypokalemia together are the basis for various arrhythmia, resulting in an increase in cardiovascular death. 18 …”

Section: Discussionmentioning

confidence: 99%

Prognosis of Older Adult Patients Suffering from Atrial Fibrillation and Hypokalemia

Wang,

Liu

et al. 2023

CIA

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Objective To examine the effects of hypokalemia on the prognosis of older adult patients with atrial fibrillation (AF). Methods We enrolled 794 older adult patients ≥ 75 years suffering from AF, and divided them into two groups according to the inclusion and exclusion criteria: Group 1, (hypokalemia group), 246 cases, serum K + <3.5 mmol/L; Group 2, (normal blood potassium group), 548 cases, 3.5mmol/L≤serum K + <5.5 mmol/L. The two groups of patients were followed for 70 months to observe the occurrence of clinical events. The primary endpoint was cardiovascular death and the secondary endpoint was all-cause death. Results The median follow-up time was 15.00 months. In terms of baseline profile characteristics, serum creatinine levels were significantly lower in Group 1 than in Group 2 patients ( P =0.002). In terms of the relationship between hypokalemia and clinical outcomes, Kaplan-Meier survival analysis revealed that the incidence of clinical primary endpoint in Group 1 was significantly higher than that in Group 2 (P < 0.001), and the incidence of the secondary endpoint did not differ significantly between the two groups ( P > 005). Based on multivariate Cox regression risk model analysis, coronary heart disease, hemoglobin content, serum uric acid and usage of anticoagulant drugs were the independent variables related to the primary endpoint of cardiovascular death (all P < 0.01). Conclusion The incidence of hypokalemia in older adult patients with AF was 30.98%. Hypokalemia was closely related to the cardiovascular death, and coronary heart disease, hemoglobin content, serum uric acid level, and usage of anticoagulant drugs were the independent risk factors for the primary endpoint event.

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“… 17 Inflammation, oxidative stress, and hypokalemia together are the basis for various arrhythmia, resulting in an increase in cardiovascular death. 18 …”

Section: Discussionmentioning

confidence: 99%

Prognosis of Older Adult Patients Suffering from Atrial Fibrillation and Hypokalemia

Wang,

Liu

et al. 2023

CIA

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“…Specifically, these cytokines can reduce the expression and function of sodium, calcium, and potassium channels, resulting in a shorter action potential (AP) duration and greater repolarization dispersion [41,42]. The impact extends to the facilitation of early after-depolarizations (EADs) and the occurrence of reentrant arrhythmias [43]. Pro-inflammatory cytokines such TNF-α, IL-1β, and IL-6 also contribute to longer action potential duration, decreased excitability, and greater dispersion of repolarization in addition to their direct effects on ion channels [41,42].…”

Section: Inflammation and Arrhythmogenesis: Mechanistic Insightsmentioning

confidence: 99%

Section: Inflammation and Arrhythmogenesis: Mechanistic Insightsmentioning

confidence: 99%

“…The role of cardiac bitter taste receptors (TAS2Rs) in the pathogenesis of heart diseases is discussed in a study titled "Cellular mechanisms and molecular pathways linking bitter taste receptor signalling to cardiac inflammation, oxidative stress, arrhythmia, and contractile dysfunction in heart diseases" [43]. According to the study by Menizibeya et al [43], abnormal TAS2R signaling may put people at risk for developing cardiac inflammatory and oxidative stress diseases, which are marked by arrhythmia and contractile dysfunction. According to the same study, cardiac TAS2Rs serve as gateway surveillance systems that monitor and identify toxins or pathogens, including microbial components, and then launch reactions that eventually result in the host being protected against aggression [43].…”

Section: Inflammation and Arrhythmogenesis: Mechanistic Insightsmentioning

confidence: 99%

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Inflammation and arrhythmogenesis: a narrative review of the complex relationship

Taghdiri

2024

Int J Arrhythm

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Background A biological mechanism called inflammation is necessary for reacting to damaging stimuli, but it can also, ironically, play a role in the formation of arrhythmias, or the group of disorders known as arrhythmogenesis. This review delves into the intricate relationship that exists between localized and systemic inflammation and the electrophysiological changes that result in abnormal heart rhythms. Main body Through oxidative stress, autonomic dysfunction, electrolyte imbalances, and coagulation activation, systemic inflammation may impact arrhythmogenicity. Similar to neuropathic alterations, direct cellular damage, and structural remodeling, localized heart inflammation also predisposes to arrhythmias. Studies demonstrating the impact of cytokines on ion channel expression and function, along with clinical associations between inflammatory indicators and arrhythmia incidence, offer the molecular insights. Immune cells like macrophages that alter cardiac conduction are involved in the interaction between inflammation and electrophysiology, which further complicates the situation. Clinical ramifications include the use of anti-inflammatory drugs to treat arrhythmic episodes and the possible adjustment of arrhythmia treatment based on inflammatory condition. Even yet, further thorough study is necessary to fully understand the efficacy of these medicines. Conclusions Arrhythmogenesis and inflammation are inherently linked by a number of mechanisms that change the electrical characteristics of the heart. Arrhythmia treatment and prevention may benefit from therapeutic approaches that reduce inflammatory processes. The difficulties that still exist in applying this information to clinical settings highlight the necessity of continuing studies to better comprehend the subtleties of inflammation-induced electrical alterations. Progress in identifying biomarkers of inflammation and developing tailored therapies will be crucial in enhancing the prognosis of individuals suffering from arrhythmogenic disorders that are aggravated by inflammation.

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“…Moreover, TAS2Rs are expressed in the taste buds of the tongue as well as in extraoral tissues such as the respiratory tract, the gastrointestinal tract, and the brain (Jeruzal‐Świątecka et al, 2020). Therefore, several works focused on the role of bitter receptors in cancer (Zehentner et al, 2021), asthma (Nayak et al, 2019), heart diseases (Welcome et al, 2023), orthopaedic disorders (Cheng et al, 2021), neurodegenerative disorders (Duarte et al, 2022) and thyroid function (Clark et al, 2015). Furthermore, it is worth mentioning that many drugs have a bitter taste, leading to poor or intermittent adherence to drug therapies, particularly in young individuals and children (Mennella et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Machine learning approaches to predict TAS2R receptors for bitterants

Ferri,

Cannariato,

Deriu

et al. 2024

Biotech & Bioengineering

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Bitter taste involves the detection of diverse chemical compounds by a family of G protein‐coupled receptors, known as taste receptor type 2 (TAS2R). It is often linked to toxins and harmful compounds and in particular bitter taste receptors participate in the regulation of glucose homeostasis, modulation of immune and inflammatory responses, and may have implications for various diseases. Human TAS2Rs are characterized by their polymorphism and differ in localization and function. Different receptors can activate various signaling pathways depending on the tissue and the ligand. However, in vitro screening of possible TAS2R ligands is costly and time‐consuming. For this reason, in silico methods to predict bitterant‐TAS2R interactions could be powerful tools to help in the selection of ligands and targets for experimental studies and improve our knowledge of bitter receptor roles. Machine learning (ML) is a branch of artificial intelligence that applies algorithms to large datasets to learn from patterns and make predictions. In recent years, there has been a record of numerous taste classifiers in literature, especially on bitter/non‐bitter or bitter/sweet classification. However, only a few of them exploit ML to predict which TAS2R receptors could be targeted by bitter molecules. Indeed, the shortage and incompleteness of data on receptor‐ligand associations in literature make this task non‐trivial. In this work, we provide an overview of the state of the art dealing with this specific investigation, focusing on three ML‐based models, namely BitterX (2016), BitterSweet (2019) and BitterMatch (2022). This review aims to establish the foundation for future research endeavours focused on addressing the limitations and drawbacks of existing models.

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Cellular mechanisms and molecular pathways linking bitter taste receptor signalling to cardiac inflammation, oxidative stress, arrhythmia and contractile dysfunction in heart diseases

Cited by 8 publications

References 418 publications

Prognosis of Older Adult Patients Suffering from Atrial Fibrillation and Hypokalemia

Prognosis of Older Adult Patients Suffering from Atrial Fibrillation and Hypokalemia

Inflammation and arrhythmogenesis: a narrative review of the complex relationship

Machine learning approaches to predict TAS2R receptors for bitterants

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