Escherichia coli Lipopolysaccharide-Induced Immunomodulation Along With Oxytocin Administration After Mating as a Treatment Protocol for Persistent Endometritis in Mares

Sharma, Sanjay; Dhaliwal, G. S.

doi:10.1016/j.jevs.2010.03.009

Cited by 8 publications

(2 citation statements)

References 44 publications

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“…In barren mares, the pregnancy rate per-cycle increased after oxytocin administration. Positive effects of oxytocin alone [18,43] or together with Escherichia coli lipopolysaccharide [44] on pregnancy rate in mares have been previously reported. Barren mares often present an age-associated impaired uterine function which makes them more susceptible for PBIE than other categories [25].…”

Section: Discussionmentioning

confidence: 90%

Relationship between Clinical Uterine Findings, Therapy, and Fertility in the Mare

Scarlet

Malama

Fischer

et al. 2023

Veterinary Sciences

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Persistent breeding-induced endometritis (PBIE) is a major cause of subfertility in horses and the susceptibility is increased by several factors. The aim of this study was to determine the effects of clinical uterine findings and PBIE therapies, respectively, on pregnancy rate in mares. The analysis included records from 220 mares (390 cycles) inseminated at an artificial insemination (AI) center in Switzerland. Gynecological examinations were performed repeatedly before and after AI to determine cervical tone, uterine edema, and intrauterine fluid accumulation. Pregnancy rate was lower (p < 0.001) in barren mares compared to mares of other reproductive status. A more flaccid cervix (p = 0.009) was observed at the time of ovulation in pregnant cycles, but there was no difference (p > 0.05) regarding uterine edema. Intrauterine fluid accumulation reduced pregnancy rate (p = 0.002). Oxytocin administration had beneficial effects on pregnancy rate (p = 0.015), especially for barren mares, while uterine lavage did not have any effect (p > 0.05). The results show that cervical tone and intrauterine fluid accumulation, but not its degree, are useful parameters for assessment of fertility in mares. Oxytocin treatment improved pregnancy rates in mares with PBIE while uterine lavage had a limited effect.

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Section: Discussionmentioning

confidence: 90%

Relationship between Clinical Uterine Findings, Therapy, and Fertility in the Mare

Scarlet

Malama

Fischer

et al. 2023

Veterinary Sciences

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“…Previously intrauterine infusion of bacterial endotoxin has reported by Hussain & Daniel (1992), Rao & Seshagiri (1998) and Reddy et al (2012). The E.coli cell wall possesses a lipopolysacharide in its cell wall and which is considered to be potent antigen according to Sharma & Dhaliwal (2010). studied and found that these substances have a chemotactic action to induce proliferation of PMN cells mostly neutrophils and macrophages and these phagocytic cells synthesize cytokines which stimulates both humoral and cellular immunity resulting in elimination of microorganisms.…”

Section: Discussionmentioning

confidence: 99%

Effect of Certain Immunomodulators on Uterine Microbiology in Cyclic Non Breeding Cows

Sahoo¹,

Mohanty²,

Padhy³

2014

AJVS

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A total number of twenty one repeat breeding cows selected after meticulous screening based on Whiteside test and Laing's criteria then allotted randomly into three equal groups (n=7). Cows in control group were lavaged with intra-uterine with 50 ml of normal saline, in group I 20 ml of fresh colostrum and in group II infusion with 10 ml of non-pathogenic E.Coli in sterile saline as intra uterine medication were given. Bacterial isolates were collected in pre-treatment stage (day0) and post treatment stage (day 21) and their concentrations (cfu/ml) were compared.In the pre treatment stage, the predominant bacterial flora and their frequency in animals constituted Klebsiella spp , Staphylococcus spp , E.coli , Enterococcus fecalis , Streptococcus spp , Proteus spp and Bacillus spp. In the post treatment sampling after twenty one days, following different drug treatments revealed inhibition of many bacterial isolates which were identified in the pre-treatment period. Klebsiella spp. was found only in normal saline group whereas it was absent in colostrum and E.coli treated group. Similarly Staphylococcus spp. was identified from a single case in colostrum treated group whereas the other two treatment regimen did not reveal their presence. Similar bacterial inhibition against Staphylococcus spp. was marked in normal saline and E.coli. The presence of non pathogenic E.coli was evident in all the treatment groups at post treatment period, indicating either their reinfection or due to its natural presence in the reproductive tract. The cows in control group projected a first insemination conception rate of 42.86%, in group-I recorded a pregnancy rate of 57.14% and in group-II three cows became pregnant (42.86%) out of seven inseminations.

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Reproductive Tract Infections

Tibary¹,

Pearson²,

Fite³

2014

Equine Infectious Diseases

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Escherichia coli Lipopolysaccharide-Induced Immunomodulation Along With Oxytocin Administration After Mating as a Treatment Protocol for Persistent Endometritis in Mares

Cited by 8 publications

References 44 publications

Relationship between Clinical Uterine Findings, Therapy, and Fertility in the Mare

Relationship between Clinical Uterine Findings, Therapy, and Fertility in the Mare

Effect of Certain Immunomodulators on Uterine Microbiology in Cyclic Non Breeding Cows

Reproductive Tract Infections

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