Escherichia coli endocarditis: seven new cases in adults and review of the literature

Branger, S.; Casalta, Jean‐Paul; Habib, Gilbert; Collard, F.; Raoult, Didier

doi:10.1007/s10096-005-1379-6

Cited by 47 publications

(66 citation statements)

References 12 publications

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“…Mortality was high (53%). In a more recent series of seven cases of endocarditis due to E. coli , patients were older (median age, 76 years; range, 60-82 years) and had underlying heart disease and diabetes [ 12 ]. Four of seven patients had urinary tract infection, which was the source of endocarditis.…”

Section: Escherichia Colimentioning

confidence: 96%

Gram-negative endocarditis

Reyes

Reyes²

2008

Curr Infect Dis Rep

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Aerobic gram-negative bacilli are rare causes of endocarditis. The epidemiology and risk factors for developing gram-negative endocarditis are evolving. New pathogens, some of which are multidrug resistant, are emerging. The role of nosocomial infections, particularly central venous catheter infections, is increasing. Medical and surgical outcomes appear to be improving with more effective antimicrobial therapy and aggressive surgical management.

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Section: Escherichia Colimentioning

confidence: 96%

Gram-negative endocarditis

Reyes

Reyes²

2008

Curr Infect Dis Rep

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“…E. coli and Pseudomonas aeruginosa were together responsible for over half of these cases. Similarly, the two largest available reviews on E. coli endocarditis were together able to identify 43 definite cases 3 4. In comparison, there are nearly 200 reported cases of P. aeruginosa producing endocarditis; however, over 95% of these cases were related to intravenous drug use, unlike the patients reported here 5…”

Section: Introductionmentioning

confidence: 61%

“…The emergence of ESBL-producing Enterobacteriaceae and multidrug-resistant strains of Pseudomonas has further complicated the management of Gram-negative bacterial endocarditis by excluding many antibiotics that are otherwise effective in endocarditis. For these reasons, cardiac surgery remains an integral component of therapy in such cases 3 7…”

Section: Discussionmentioning

confidence: 99%

Community-acquired multidrug-resistant Gram-negative bacterial infective endocarditis

Naha

Acharya

et al. 2014

BMJ Case Reports

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We describe two cases of bacterial endocarditis secondary to multidrug-resistant Gram-negative organisms. In both cases, the diagnosis was made in accordance with the modified Duke's criteria and confirmed by histopathological analysis. Furthermore, in both instances there were no identifiable sources of bacteraemia and no history of contact with hospital or other medical services prior to the onset of symptoms. The patients were managed in similar fashion with prolonged broad-spectrum antibiotic therapy and surgical intervention and made complete recoveries. These cases highlight Gram-negative organisms as potential agents for endocarditis, as well as expose the dissemination of such multidrug-resistant bacteria into the community. The application of an integrated medical and surgical approach and therapeutic dilemmas encountered in managing these cases are described.

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“…Metastatic blood borne infections with E. coli that have been reported are discitis, vertebral osteomyelitis and joint space infection [1,2]. However, endocarditis and other endovascular infections are rare [3,4]. …”

Section: Introductionmentioning

confidence: 99%

Multi-resistant Escherichia coli and mycotic aneurysm: two case reports

et al. 2009

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IntroductionMycotic aneurysms account for a small proportion of all aneurysms. Escherichia coli a gram-negative organism, is recognised as a rare cause of aortic aneurysm. We report two cases of mycotic aneurysm caused by the same strain of multi-resistant Escherichia coli. The purpose of this case report is to highlight the possibility that this strain may be associated with an increased risk of endovascular infection especially in extra-aortic sites. These aneurysms can be difficult to detect and can have serious consequences.Case presentationIn case one, the patient presented with symptoms and signs of septicaemia secondary to a urinary tract infection. Despite adequate treatment the patient continued with pyrexia and raised inflammatory markers, therefore a series of CT scans of the abdomen and thorax were performed, which revealed two intra-thoracic pseudo-aneurysms with associated haematomas. In case two, the patient also developed Escherichia coli septicaemia. On day 44 he developed a swelling on the right side of his neck. An ultrasound scan showed a pseudoaneurysm of the right common carotid artery.ConclusionsWhilst a case report cannot prove that a heightened risk exists, we suggest that it is an area worthy of further surveillance. We recommend when older patients with atheromatosis develop prolonged Escherichia coli septicaemia, the possibility of an infected aneurysm should be borne in mind.

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Escherichia coli endocarditis: seven new cases in adults and review of the literature

Cited by 47 publications

References 12 publications

Gram-negative endocarditis

Gram-negative endocarditis

Community-acquired multidrug-resistant Gram-negative bacterial infective endocarditis

Multi-resistant Escherichia coli and mycotic aneurysm: two case reports

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