Escalation of Glaucoma Therapy after Penetrating Keratoplasty

Intraocular pressure elevation after Descemet’s stripping endothelial keratoplasty

“…According to the protocol of the current study, which required the presence of increased IOP for at least two months after surgery, similar to other studies [14][15][16][17], and along with our anterior segment observations at two months and beyond showing an absence of clinical signs of retained viscoelastics, ciliary injection, or anterior chamber inflammatory cells, we excluded any early causes of IOP elevation (including retained viscoelastics and inflammation) as the inciting factors for IOP elevation in our cases. Previous studies report the incidence of IOP elevation after PKP to vary between 20 to 34.9 % [14][15][16][17]. These studies, however, provided information on the incidence of IOP elevation including patients with pre-existing glaucoma and postoperative IOP elevation.…”

Graft Failure and Intraocular Pressure Control After Keratoplasty in Iridocorneal Endothelial Syndrome

“…In addition, a recent study has shown better long-term endothelial cell survival rate in DSAEK grafts compared 26 Further studies are needed to determine if this endothelial cell survival advantage is similar for DSAEK in patients with ICE. Glaucoma and glaucoma surgery have been reported to be major risk factors for graft failure after keratoplasty, 22,[32][33][34][35] and evidence of lower IOP during follow-up (excluding hypotony) has been associated with reduced risk of graft failure. 36 A recent multivariate analysis of 835 cases of Descemet membrane stripping endothelial keratoplasty revealed that prior glaucoma surgery was a significant risk factor for corneal endothelial failure.…”

“…The need for escalation of IOP-lowering therapy postkeratoplasty has been well described. 22,23,[32][33][34]36,43 Few studies, however, have reported results of escalation of antiglaucoma therapy after keratoplasty in eyes with ICE syndrome. These studies report small numbers of ICE patients with glaucoma undergoing keratoplasty, with little elaboration on graft survival or IOP control postkeratoplasty surgery.…”

Postoperative Complications After Primary Adult Optical Penetrating Keratoplasty: Prevalence and Impact on Graft Survival

“…3,[29][30][31][32] Postoperative complications such as endothelial rejection, [33][34][35][36] glaucoma worsening, [37][38][39][40][41][42][43][44][45][46][47] bacterial keratitis, [48][49][50][51][52][53][54][55][56][57][58][59][60][61] persistent epithelial defects (PEDs), [48][49][50][51][52][53][54][55][56][57][58][59][60][61][62][63][64] and wound dehiscence …”