¿Es la pancreatitis crónica una enfermedad rara en Chile?: ¿Subdiagnóstico, baja prevalencia o ambos?

F, Zoltán Berger; A, Carla Mancilla

doi:10.4067/s0034-98872016001200005

Cited by 4 publications

(3 citation statements)

References 20 publications

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“…During the present investigation, 83.3% of the patients with EPI had FE-1 levels <100 μg/g, indicating an advanced stage of the disease. Similarly, a study of Chilean patients with CP found a comparable prevalence (66.9%) [ 12 ], whereas another study in Spain reported a lower prevalence of 38.8% [ 13 ].…”

Section: Discussionmentioning

confidence: 97%

Role of Exocrine and Endocrine Insufficiency in the Management of Patients with Chronic Pancreatitis

Diéguez-Castillo

Jiménez-Luna

Martín-Ruíz

et al. 2020

JCM

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Background: Exocrine pancreatic insufficiency results from the destruction of the pancreatic parenchyma and is diagnosed by using direct or indirect tests, both of which have shortcomings. Chronic pancreatitis is the most frequent cause of this pathology in adults. Methods: Patients meeting radiological or histological diagnostic criteria of chronic pancreatitis are enrolled and the stool elastase test is conducted, considering fecal elastase levels >200 µg/g to represent normal pancreatic function, and levels <200 μg/g to indicate the presence of exocrine pancreatic insufficiency. Additionally, we determine the body mass index of the patients and study their nutritional status and main biochemical and hematological variables, including their glucose and hemoglobin A1c (HbA1c) levels. Results: Exocrine pancreatic insufficiency is detected in 60% of the patients. Among these, 83.3% are severe cases, and 72% of the latter also are diagnosed with endocrine pancreatic insufficiency (diabetes mellitus). During the nutritional status study, HbA1c levels are significantly higher, and magnesium and prealbumin levels are significantly lower in patients with exocrine pancreatic insufficiency than in those without this disease. Conclusions: Exocrine and endocrine pancreatic insufficiency are highly prevalent among patients with chronic pancreatitis and an early diagnosis of these diseases is vital to improve the clinical management of these patients and reduce their risk of mortality.

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Section: Discussionmentioning

confidence: 97%

Role of Exocrine and Endocrine Insufficiency in the Management of Patients with Chronic Pancreatitis

Diéguez-Castillo

Jiménez-Luna

Martín-Ruíz

et al. 2020

JCM

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“…La Pancreatitis crónica (PC) es una "condición fibroinflamatoria persistente y frecuentemente evolutiva del páncreas, más común en fumadores, alcohólicos o individuos con predisposición genética, que clínicamente se presenta en los estadios iniciales con episodios intermitentes de dolor y en las fases tardías con dolor, calcificaciones e insuficiencia respiratoria" 1,2,4,13 .…”

Section: Introductionunclassified

“…Los pacientes jóvenes regularmente debutan con dolor abdominal y complicaciones severas, mientras que en los pacientes mayores puede presentarse asintomática u oligosintomática 2,3 . Se ha documentado predisposición genética relacionada con mutaciones de los genes CFTR, PRSS1, SPINK1 Y CTRC; de igual manera en algunos estudios hasta 46% de los casos tenían etiología alcohólica y el tabaquismo como factor de riesgo en 50 % para varones, en mujeres más frecuentemente son de etiología idiopática y obstructiva 3,4 .…”

Section: Introductionunclassified

Clasificación de Rosemont para pancreatitis crónica

Arenas Delgado,

Segovia Vergara,

Sanchez Montes

et al. 2024

Gastroenterol. latinoam.

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Chronic pancreatitis is a persistent fibroinflammatory disease of the pancreas, more common in smokers or alcoholics. Genetic predisposition with mutations in various genes has also been documented. It typically presents with recurrent abdominal pain and endocrine and exocrine dysfunction, potentially progressing to pancreatic cancer and severe complications in later stages. In Chile, an annual incidence of 0.8 cases per 100,000 inhabitants is estimated, with a prevalence of 6.1 cases per 100,000 inhabitants. Early diagnosis is a current challenge for which endosonography has emerged as a sensitive and specific diagnostic tool, especially with the implementation of the Rosemont classification. Various studies have validated the utility of this classification. However, the limited availability of endosonography in some countries, such as Chile, establishes challenges for generalizing its application. It is expected that in the future, the Rosemont classification will become a standard for the diagnosis of chronic pancreatitis.

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Racial Differences in Chronic Pancreatitis. An Explanation for South America?

Berger

Mancilla

2017

American Journal of Gastroenterology

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¿Es la pancreatitis crónica una enfermedad rara en Chile?: ¿Subdiagnóstico, baja prevalencia o ambos?

Cited by 4 publications

References 20 publications

Role of Exocrine and Endocrine Insufficiency in the Management of Patients with Chronic Pancreatitis

Role of Exocrine and Endocrine Insufficiency in the Management of Patients with Chronic Pancreatitis

Clasificación de Rosemont para pancreatitis crónica

Racial Differences in Chronic Pancreatitis. An Explanation for South America?

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