Erythropoietin Potential as an Antiapoptotic Agent in ISCEMIC Stroke using Unilateral Right Common Carotid Artery Occlusion (RUCCAO) Model

Khotib, Junaidi; Mentari, Ika Ayu; Rahmadi, Mahardian; Suharjono, Suharjono

doi:10.5958/0976-5506.2019.00871.4

Cited by 4 publications

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“…In this study, we obtained acute stroke patients with high cortisol levels of 16 subjects or 50% of the total subject. In the patients with acute stroke, there was an increase or abnormality of ACTH secretion and cortisol associated with extensive infarction, poor functional outcome and increased mortality 12 .…”

Section: Discussionmentioning

confidence: 99%

Journal of Forensic Medicine & Toxicology, April-June 2020, Vol. 14, No. 2 1633 The Impact of High Cortisol Level in Increasing Incidence of Infection Cases among Acute Stroke Patients

2020

IJFMT

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Background: Infection in the stroke was a treatment major problem, because it determines the prognosis. In the acute phase of stroke, high level cortisol may lead to a decreased immune system and patients tend to be more susceptible to infection. The correlation of serum cortisol level among acute stroke patients with incidence of infection was not fully investigated. Objective:The aim of this study was to determine the relationship between initial serum cortisol levels and the incidence of infection in acute stroke patients.Method: A prospective cohort study was conducted on 32 of acute stroke patients who admitted in RSUD Dr. Soetomo Surabaya during the period December 2015 to February 2016. Total of 2 cc to the venous blood within 48 hours in onset of stroke being examined of serum cortisol. During the 7 days of hospitalization, the patient was observed for signs of infection, both clinically and the investigation in accordance with the operational definition. Results:In the infected group there were 8 people (50%) with high cortisol levels (p = 0.015; RR 15,000; 95% IK 1.583-143,171); 6 people were (50%) using urine catheter (p = 0.049; RR 6,667; 95% IK 1.067-30.085); And 6 people were (54.5%) using NGT (p = 0,035; RR 7,200;557). In multivariate analysis obtained that Odds Ratio (OR) 15,468 based on high cortisol and OR 7,469 based on NGT usage. Conclusion:High cortisol levels and the use of NGT had the effect on the incidence of infection in acute stroke.

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Section: Discussionmentioning

confidence: 99%

Journal of Forensic Medicine & Toxicology, April-June 2020, Vol. 14, No. 2 1633 The Impact of High Cortisol Level in Increasing Incidence of Infection Cases among Acute Stroke Patients

2020

IJFMT

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The Impact of High Cortisol Level in Increasing Incidence of Infection Cases Among Acute Stroke Patients

Handaayani

Hamdan

Sugianto

et al. 2020

j comput theor nanosci

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Infection in the stroke was a treatment major problem, because it determines the prognosis. In the acute phase of stroke, high level cortisol may lead to a decreased immune system and patients tend to be more susceptible to infection. The correlation of serum cortisol level among acute stroke patients with incidence of infection was not fully investigated. The aim of this study was to determine the relationship between initial serum cortisol levels and the incidence of infection in acute stroke patients. A prospective cohort study was conducted on 32 of acute stroke patients who admitted in RSUD Dr. Soetomo Surabaya during the period December 2015 to February 2016. Total of 2 cc to the venous blood within 48 hours in onset of stroke being examined of serum cortisol. During the 7 days of hospitalization, the patient was observed for signs of infection, both clinically and the investigation in accordance with the operational definition. In the infected group there were 8 people (50%) with high cortisol levels (p = 0.015; RR 15,000; 95% IK 1.583-143,171); 6 people were (50%) using urine catheter (p = 0.049; RR 6,667; 95% IK 1.067-30.085); And 6 people were (54.5%) using NGT (p = 0,035; RR 7,200; 95% IK 1.311-39,557). In multivariate analysis obtained that Odds Ratio (OR) 15,468 based on high cortisol and OR 7,469 based on NGT usage. High cortisol levels and the use of NGT had the effect on the incidence of infection in acute stroke.

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Quercetin attenuates acute predator stress exposure-evoked innate fear and behavioral perturbation

Anggreini

Ardianto

Rahmadi

et al. 2019

Journal of Basic and Clinical Physiology and Pharmacology

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Background Oxidative stress plays a pivotal role in the pathophysiology and pathogenesis of mental diseases, such as depression or anxiety. Psychological stress induced by predatory stimulus is one of the models that explain how induced affective behavior is manifested as a depression-like state. Quercetin is a flavonoid that exhibits potential pharmacological activity on mental diseases. Thus, the present study was designed to investigate the effect of quercetin on innate fear and affective behavior induced by repeated predator stress exposure on mice. Materials and methods ICR mice were exposed to predatory stress for 3 days. Quercetin at a dose of 50 mg/kg was given intraperitoneally along with stress induction. The freezing behavior during the stress induction was analyzed. The anxiety-like and depressive-like behaviors and cognitive and motor functions were examined on the last day of induction. Results Predatory stress increased the affective behaviors (anxiety-like and depressive-like behaviors) and produced freezing behavior without alterations in the cognitive function and exploratory behavior. Treatment with quercetin 50 mg/kg attenuated the freezing, anxiety-like and depressive-like behaviors. Conclusions Repeated predator stress exposure causes both innate fear and depression-like state for the prey animals. Quercetin may have a protective effect against depression and alleviates the fear of traumatic events.

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Erythropoietin Potential as an Antiapoptotic Agent in ISCEMIC Stroke using Unilateral Right Common Carotid Artery Occlusion (RUCCAO) Model

Cited by 4 publications

References 0 publications

Journal of Forensic Medicine & Toxicology, April-June 2020, Vol. 14, No. 2 1633 The Impact of High Cortisol Level in Increasing Incidence of Infection Cases among Acute Stroke Patients

Journal of Forensic Medicine & Toxicology, April-June 2020, Vol. 14, No. 2 1633 The Impact of High Cortisol Level in Increasing Incidence of Infection Cases among Acute Stroke Patients

The Impact of High Cortisol Level in Increasing Incidence of Infection Cases Among Acute Stroke Patients

Quercetin attenuates acute predator stress exposure-evoked innate fear and behavioral perturbation

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