Erythropoietin in health and disease

Eckardt, Kai‐Uwe; Bauer, Christian

doi:10.1111/j.1365-2362.1989.tb00205.x

Cited by 39 publications

(19 citation statements)

References 102 publications

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“…This local P02 is detected by a putative oxygen sensor regulating EPO secretion. 7 - 8 Limited information is currently available on the influence of hyperoxia on the regulation of EPO secretion. 9 -" Changes in renal hemodynamics and tubular function are well described in hypertension.…”

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Effect of isobaric hyperoxemia on erythropoietin secretion in hypertensive patients.

Kokot

Franek

et al. 1994

Hypertension

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We assessed the influence of hyperoxemia on erythropoietin secretion in patients with various etiological forms of arterial hypertension (essential, n=15; renoparenchymal, n=16; renovascular, n=15) and in 15 healthy subjects. On the first day of the study, blood was withdrawn at 1-hour intervals for the estimation of erythropoietin during a total of 6 hours and at 2-hour intervals for the assessment of PO2. Three days later the same parameters were assessed again at identical time intervals, but the subjects were breathing pure oxygen during the first 2 hours. Breathing with pure oxygen resulted in a significant increase of blood (EPO) was introduced in the treatment of anemia caused by renal failure, the most important side effect of the therapy was an increase of blood pressure or worsening of preexisting hypertension. 12 The proposed mechanisms of hypertension during EPO treatment were increased blood viscosity, loss of hypoxic vasodilation, and inappropriately reduced cardiac output after correction of anemia.24 Furthermore, recent studies suggested that EPO could induce a direct or hormonally mediated vasopressor effect. 36The main stimulus for EPO secretion seems to be a decrease of oxygen supply to the renal tissue.7 As shown by Kurtz et al,7 EPO secretion is determined by the ratio of oxygen supply to oxygen demand in the kidney. The parameter that adequately reflects this ratio is Po 2 in small postcapillary peritubular veins. This local P02 is detected by a putative oxygen sensor regulating EPO secretion. -8 Limited information is currently available on the influence of hyperoxia on the regulation of EPO secretion.9 -" Changes in renal hemodynamics and tubular function are well described in hypertension. © 1994 American Heart Association, Inc.sive patients. In patients with essential hypertension, unlike in healthy subjects and patients with other etiological forms of arterial hypertension, only a very short-term suppression of erythropoietin levels was observed during hyperoxemia. No significant changes in blood pressure during breathing with pure oxygen were found in any of the studied groups. We conclude the following: (1) Isobaric hyperoxia exerts a significant suppressive effect on plasma erythropoietin levels both in patients with different etiological forms of arterial hypertension and in healthy subjects. (2) Patients with essential hypertension are characterized by a quantitatively different response of plasma erythropoietin to isobaric hyperoxia compared with healthy subjects and patients with renoparenchymal or renovascular hypertension. (3) Oxygen physically dissolved in blood plasma seems to be an important determinant of erythropoietin secretion independent of hemoglobin concentration and oxygen saturation. (Hypertension. 1994;24:486-490.) Key Words • erythropoietin • hypertension, essential • erythropoiesis • oxygen regulation of EPO production, both of these factors might influence EPO secretion. Limited available information on endogenous EPO in arterial hypertension did no...

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Effect of isobaric hyperoxemia on erythropoietin secretion in hypertensive patients.

Kokot

Franek

et al. 1994

Hypertension

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“…Böbrek kistlerinde parankime bası ile oluşan doku hipoksisinin EPO sentezini artırdığı ve hastada polisitemiye neden olduğu ileri sürülmüştür. 11 Olgumuzda da EPO seviyesi yüksek saptanmıştır. Çoğu hastada tedaviye gerek yoktur.…”

Section: Discussionunclassified

Renal Lymphangiectasia Presenting with Polycythemia: Case Report

Demir¹,

Ersoy²,

Karaca³

et al. 2017

Turkiye Klinikleri J Case Rep

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“…Actually, the fol lowing data from the literature suggest that, despite the small arteriovenous difference of oxygen tension, the energy balance of some, probably tubular, cell types in the kidney is affected by changes of the oxygen transport capacity of blood: the oxidative metabolism of some structures in the kidney appear to be limited by oxygen availability even under con ditions of normal oxygen supply [11][12][13][ and moderate decreases in oxygen supply lead to decreased content of renal ATP [14]. The stim ulus for secretion of erythropoietin in the kid ney seems to depend in some way on transport work in the proximal tubule [15]. One possible explanation for it is that erythropoietin pro duction might be linked to an energy deficit rather than to the decrease of arterial oxygen content per se.…”

Section: Discussionmentioning

confidence: 99%

Anemia Induces 5’-Nucleotidase in Fibroblasts of Cortical Labyrinth of Rat Kidney

Hir

Eckardt

Kaissling

1989

Kidney Blood Press Res

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We recently observed a strong increase of 5’-nucleotidase in renal fibroblasts of rats that were anemic due to an immunity against erythropoietin. In order to test if the change of 5’-nucleotidase was related with anemia, we studied the distribution of the enzyme in irradiated rats treated with phenylhydrazine. The hematocrit of these rats decrased to 15% within 4 days and erythropoietin levels were more than 200 times over controls. After 7 days a histochemical study showed that the enzymatic activity and the immunoreactivity for 5’-nucleotidase was markedly enhanced in the fibroblasts of the cortical labyrinth. There was no modification of 5’-nucleotidase in other cell types of the kidney. The 5’-nucleotidase activity of renal fibroblasts in cell culture increased by 72% upon addition of 160 µM 5’-AMP to the culture medium for 8 days. We propose that anemia provokes an energy deficit in some structure in the cortical labyrinth. This might increase the concentration of 5’-AMP which would induce 5’-nucleotidase. An interesting consequence of these events would be an increased production of adenosine in the direct vicinity of some of its putative targets, the glomerular arterioles and the erythropoietin-producing cells.

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Erythropoietin in health and disease

Cited by 39 publications

References 102 publications

Effect of isobaric hyperoxemia on erythropoietin secretion in hypertensive patients.

Effect of isobaric hyperoxemia on erythropoietin secretion in hypertensive patients.

Renal Lymphangiectasia Presenting with Polycythemia: Case Report

Anemia Induces 5’-Nucleotidase in Fibroblasts of Cortical Labyrinth of Rat Kidney

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