Erythropoietin; bright future and new hopes for an old drug

Kadkhodaee, Mehri

doi:10.5812/nephropathol.7475

Cited by 16 publications

(10 citation statements)

References 4 publications

(2 reference statements)

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“…Medicinal plants play a central role as traditional medicine for their therapeutic or preventive effects against drug or chemical toxicities (2)(3)(4)(5), however, some herbs, which even have been used traditionally might have acute or chronic toxicity. Among the plants that might have liver toxicity based on the traditional beliefs of people in Chaharmahal and Bakhtiari (a province in Iran), is Stachys lavandulifolia (1).…”

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confidence: 99%

Assessing the toxic effects of hydroalcoholic extract of Stachys lavandulifolia Vahl on rat’s liver

Taghikhani¹,

Afrough²,

Ansarisamani³

et al. 2014

BLL

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Aims: Stachys lavandulifoliaVahl is a frequently used plant to treat different diseases, but its probable toxic effects have not been reported yet. This study aimed to study the toxicity of the extract on rats' liver. Methods: In this experimental study, 100 rats were designated into 10 groups and injected normal saline or Stachys lavandulifolia Vahl extract at 50, 100, 150, and 200 mg/kg, intraperitoneally for 28 days. Four case groups and one control group were examined for ALT, AST and ALP after one month and the other groups were evaluated after two months. Results: In the fi rst month, the increase of ALP at all doses and the increase of AST at 200 mg/kg was significant, compared to the control group (p<0.05). In the second month, AST increased at the dosage of 150mg/ kg, and ALP decreased at the dosage of 100 mg/kg, compared to the control group (p<0.05). Histopathological assessment showed a signifi cant dose dependent increase both in necrotic-infl ammatory reactions and fi brotic lesions, in the fi rst and second months, compared to the control group (p<0.001). Conclusions: The Stachys lavandulifolia extract injected intraperitoneally has hepatotoxic effect, which is not eliminated by the drug withdrawal. Therefore, it is necessary to be consumed with caution (Tab. 4, Fig. 1

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confidence: 99%

Assessing the toxic effects of hydroalcoholic extract of Stachys lavandulifolia Vahl on rat’s liver

Taghikhani¹,

Afrough²,

Ansarisamani³

et al. 2014

BLL

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“…The etiologies of renal failure were diabetic nephropathy, hypertension, various glomerular diseases, autosomal dominant poly cystic kidney disease(ADPKD) and also urinary tract infections [32][33][34][35][36][37][38].According to the severity of secondary hyperparathyroidism, each patient was treated with oral active vitamin D3 (Rocaltrol), calcium carbonate, and Rena-Gel capsules at various doses. According to the severity of anemia, patients were treated with IV iron therapy Iron Source (venofer) at various doses after each dialysis session .All patients were under treatments of 6 mg folic acid daily, oral vitamin B-complex tablet daily and also 2000 U IV Eprex (recombinant human erythropoietin (rHuEPO) were given to each patient after each dialysis session routinely [39][40][41]. Exclusion criteria were active or chronic infection.…”

Section: Methodsmentioning

confidence: 99%

Age and Dialysis Adequacy in Maintenance Hemodialysis Patients

Nasri¹

2013

Ann Clin Anal Med

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ÖzetAmaç: Dializin optimal dozu ve sıklığı sorunu, dializ tedavisi alımında en önemli sorun başlığı olmuştur. Biz yaşın, bazı hemodiyaliz parametrelerin, özellikle üre reduksiyon hızı ile (URR) hemodializ yeterliliği üzerindeki etkisini değerlendirmeyi ve bu parametreleri diabetli ve diabetli olmayan hastalar arasında karşılaştırmaya çalıştık. Gereç ve Yöntem: İdame hemodiyaliz tedavisi alan End-stage (SON EVRE) hastalar dikkate alındı. Üre redüksiyon hızı ve boy kilo endeksleri hesaplandı. Bulgular: Tümü 60 kişi olan hastalar (K=21, E=39) 44 non-diyabetik hemodiyaliz(F=15, M=29) ve 16 (F=6, M=10) diyabetik hemodiyaliz hastasından oluşmakta idi. Non-diyabetikler ve diyabetikler arasında diyaliz yeterliliği açısından, diyabetik grupta düşük değerlerle, dikkate değer bir fark gözlendi ve 50 yaşındakilerle ve 50 yaş üstü hastalarda daha düşük değerlerle, kreatinin ve diyaliz yeterliliği açısından önemli bir fark gözlendi. Tüm hemodiyaliz hastalarında yaş ve hemodiyaliz yeterliliği arasın-da önemli bir negatif korelasyon gözlendi, ve aynı zamanda yaş ile serum kreatinin arasından dikkate değer bir negatif korelasyon belirlendi. Tartışma: Yaşın hemodiyaliz üzerine negatif etkisi daha fazla dikkate alınmalıdır, bu bakış açısıyla yaşlı hastalarda sıklıkla gözlenen diyaliz komplikasyonları azaltılabilir. Anahtar KelimelerHemodializ; Yaş; Üre Azalma Oranı; Diabetus Mellitus Abstract Aim: The issue of optimal dialysis dose and frequency has been a central topic in the delivery of dialysis treatment. We aimed to consider the effects of age on some hemodialysis parameters specially dialysis adequacy by urea reduction rate (URR) and to compare these parameters between diabetics and non diabetic HD(hemodialysis) patients. Material and Method: Patients with end-stage renal disease (ESRD), undergoing maintenance hemodialysis treatment were considered. The urea reduction rate and body mass index were calculated. Results: The total patients were 60 (F=21 M=39), consisting of 44 non diabetic hemodialysis patients (F=15 M=29), and 16 diabetic hemodialysis patients (F=6 M=10). A significant difference of dialysis adequacy between non-diabetics and diabetics was observed with lower values in diabetic group and a significant difference of dialysis adequacy and creatinine was observed in patients, with ages below and more than 50 years old with lower values in older patients. A significant negative correlation of age with dialysis adequacy in total hemodialysis patients and a significant negative correlation of age with serum creatinine were observed. Discussion:The negative effect of age on dialysis adequacy needs more attention to this aspect to reduce the dialysis complications which is frequently observed in older patients.

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“…Oxidative stress has also been reported in the tubular toxicity of gentamicin. Thus, gentamicin enhanced reactive oxygen species (ROS) formation [9,10] and ROS-induced cell death was found to have a role in gentamicin-mediated acute renal failure [11,12]. Therefore, treatment with antioxidants might be effective to ameliorate the damage [12,13].…”

Section: Introductionmentioning

confidence: 99%

Astaxanthin; a Promising Protector Against Gentamicin-Induced Nephrotoxicity in Rats

Mosaad¹,

Gobba²,

Hussein

2016

CPB

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Gentamicin is an aminoglycoside antibiotic widely used against infections caused by Gram-negative microorganisms. Nephrotoxicity is the main limitation to its therapeutic use. The objective of this study was to evaluate the potential protective effect of astaxanthin on the renal damage generated by gentamicin in rats, in an attempt to understand its mechanism of action, which may pave the way for possible therapeutic applications. The daily oral administration of the astaxanthin at a concentration of 50 mg/kg for 15 days to gentamicin (80 mg/kg.b.w) treated rats showed a significant decrease (p<0.05) in plasma creatinine, urea, TNF-α as well as plasma and renal MDA and HP. The treatment also resulted in a significant increase in hemoglobin, plasma sodium, potassium and TAS as well as renal total protein, GSH, Pr-SHs, G6PD, SOD, GPx, CAT and GR levels. The histological examinations of renal tissues in this study revealed damage and glomerular infiltration in gentamicin treated rats. The presented data suggest that astaxanthin has a significant prophylactic action against gentamicin-induced nephrotoxicity in rats. The effect was more pronounced in case of astaxanthin pre-treatment compared with administration of astaxanthin post-treatment. Taken together, astaxanthin has a potential as a protective and therapeutic agent for nephrotoxicity and deserves clinical trial in the near future as an adjuvant therapy in patients treated with gentamicin.

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Erythropoietin; bright future and new hopes for an old drug

Cited by 16 publications

References 4 publications

Assessing the toxic effects of hydroalcoholic extract of Stachys lavandulifolia Vahl on rat’s liver

Assessing the toxic effects of hydroalcoholic extract of Stachys lavandulifolia Vahl on rat’s liver

Age and Dialysis Adequacy in Maintenance Hemodialysis Patients

Astaxanthin; a Promising Protector Against Gentamicin-Induced Nephrotoxicity in Rats

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