Erythropoietin attenuates neuronal injury and potentiates the expression of pCREB in anterior horn after transient spinal cord ischemia in rats

Sönmez, Ataç; Kabakci, Birol; Vardar, Enver; Gürel, Duygu; Sonmez, Ulker; Orhan, Yahya T.; Açıkel, Ünal; Gökmen, Ali Necati

doi:10.1016/j.surneu.2006.11.045

Cited by 23 publications

(15 citation statements)

References 41 publications

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“…In addition, liver contributes to 10-15% of circulating plasma levels [32]. Minimal expression of EPO mRNA has also been demonstrated in the brain cortex, cerebellum, hippocampus, pituitary gland [68,78], placenta [23], testes, spleen, and lung [70]. EPO is mainly crucial for the survival, proliferation, and differentiation in the erythrocytic lineage [45].…”

Section: Production and Site Of Actionmentioning

confidence: 99%

“…This complication was adequately demonstrated in heart surgery operations. The primary targets of damage due to the inducted ischemia are motor neurons in the ventral horn of SC [18,68].…”

Section: Ischemia Modelsmentioning

confidence: 99%

“…The aforementioned problems are surpassed with the administration of exogenous rhEPO which has been suggested to produce substantial neuroprotection in animal models of traumatic SCI [4,11,19,33,36,37,39,43,44,62,74,75], spinal nerve root crush injury [66], transient SC ischemia [18,68], and SC inflammation in EAE [1]. The principal findings of the above studies are shown in Table 1.…”

Section: Exogenously Administered Epomentioning

confidence: 99%

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Erythropoietin in spinal cord injury

Matis

Birbilis

2008

Eur Spine J

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Spinal cord injury (SCI) is a devastating condition for individual patients and costly for health care systems requiring significant long-term expenditures. Cytokine erythropoietin (EPO) is a glycoprotein mediating cytoprotection in a variety of tissues, including spinal cord, through activation of multiple signaling pathways. It has been reported that EPO exerts its beneficial effects by apoptosis blockage, reduction of inflammation, and restoration of vascular integrity. Neuronal regeneration has been also suggested. In the present review, the pathophysiology of SCI and the properties of endogenous or exogenously administered EPO are briefly described. Moreover, an attempt to present the current traumatic, ischemic and inflammatory animal models that mimic SCI is made. Currently, a clearly effective pharmacological treatment is lacking. It is highlighted that administration of EPO or other recently generated EPO analogues such as asialo-EPO and carbamylated-EPO demonstrate exceptional preclinical characteristics, rendering the evaluation of these tissue-protective agents imperative in human clinical trials.

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Section: Production and Site Of Actionmentioning

confidence: 99%

“…This complication was adequately demonstrated in heart surgery operations. The primary targets of damage due to the inducted ischemia are motor neurons in the ventral horn of SC [18,68].…”

Section: Ischemia Modelsmentioning

confidence: 99%

Section: Exogenously Administered Epomentioning

confidence: 99%

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Erythropoietin in spinal cord injury

Matis

Birbilis

2008

Eur Spine J

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“…The most vulnerable organs are the kidneys and the spinal cord [1]. Recombinant human erythropoietin (rhEPO) protected against spinal cord I/R injury [2,3], and, in fact, we previously showed in swine that 300 IU kg -1 rhEPO prior to aortic balloon occlusion and during early reperfusion reduced both thoracic spinal cord neuronal damage and glial apoptosis. Motor neuron function, however, did not recover, most likely due to the low dose of rhEPO administered and/or as a result of the marked tissue damage [4].…”

Section: Introductionmentioning

confidence: 99%

Comparison of carbamylated erythropoietin-FC fusion protein and recombinant human erythropoietin during porcine aortic balloon occlusion-induced spinal cord ischemia/reperfusion injury

et al. 2011

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“…In addition to being a hematopoietic factor, erythropoietin has multiple protective effects, such as antiapoptic, antioxidant, anti-inflammatory, and angiogenic effects [11]. Sonmez et al recently reported that erythropoietin attenuated neuronal injury in anterior horn after transient spinal cord ischemia in rats [12]. Experimental studies also revealed that erythropoietin have protective effects against IR injury in liver [13], lung [14], and myocardium [15].…”

Section: Introductionmentioning

confidence: 99%