The Protective Effect of Erythropoietin on Renal Injury Induced by Abdominal Aortic-Ischemia-Reperfusion in Rats

Kiriş, İlker; Kapan, Sahin; Kilbas, Aynur; Yılmaz, Nigar; Altuntaş, İrfan; Karahan, Nermin; Okutan, Hüseyin

doi:10.1016/j.jss.2007.12.752

Cited by 40 publications

(27 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These results were furtherly supported by morphometric and statistical analysis which proved a significant increase in the mean numbers of the affected glomeruli. These findings were in accordance with earlier studies [6,14] .…”

Section: Discusionsupporting

confidence: 94%

Role of Erythropoietin Induced Stem Cell Mobilization in the Repairing of Acute Kidney Injury Following Ischemia Reperfusion in Albino Rats: A Histological Study

Nada

Ahmed

Farag

et al. 2017

Journal of Medical Histology

View full text Add to dashboard Cite

Background: The incidence of acute kidney injury (AKI), the new term for acute renal failure, has increased in recent years. Ischemia-reperfusion (IR) is one of the main causes of AKI. Erythropoietin (EPO) is a complex molecule, which regulates red blood cell production in the bone marrow. Recent studies provide evidence of potential therapeutic effect of EPO on AKI. Aim of the Work: Investigate the role of EPO in mobilization of bone marrow derived stem cells and its role in repairing AKI. Materials and Methods:This study included 32 adult male albino rats, divided into three groups; control, non-treated IR and EPO treated group. AKI was done by induction of IR via clamping both renal pedicles for 40 minutes and EPO 5000 U|kg was injected in treated group once intraperitoneally immediately after IR. Rats were sacrificed 48 hours and 1 week after intervention, then renal sections were stained with hematoxylin & eosin, PAS and immunohistochemically for CD34. Results: Erythropoietin improved the impaired kidney manifestations occurred by IR including increasing the reduced urea and creatinine levels, improved histological architecture of kidney. Also, increasing CD34 immunopositive hematopoietic and endothelial progenitor stem cells. Conclusion: This work concluded that administration of EPO at time of renal IR resulted in enhanced mobilization of stem cells resulting in structural recovery and improved functions.

show abstract

Section: Discusionsupporting

confidence: 94%

Role of Erythropoietin Induced Stem Cell Mobilization in the Repairing of Acute Kidney Injury Following Ischemia Reperfusion in Albino Rats: A Histological Study

Nada

Ahmed

Farag

et al. 2017

Journal of Medical Histology

View full text Add to dashboard Cite

show abstract

“…24,26 There is evidence that a shorter duration of ischemia leads to enough remote renal injury to demonstrate a difference between control and treatment groups. 25 In addition, in the clinical settings, other factors such as blood loss, hypotension, preexisting renal disease, and comorbidities such as diabetes and cardiac events would also have an impact on renal injury.…”

Section: Discussion the Role Of Hydrogen Sulfide In A Rodent Model Ofmentioning

confidence: 99%

Hydrogen Sulfide Reduces Inflammation Following Abdominal Aortic Occlusion in Rats

Hunter

Hosgood

Patel

et al. 2015

Annals of Vascular Surgery

View full text Add to dashboard Cite

“…Naito et al implicated decreased serum Epo concentration for [11] the cardiac remodeling mechanisms induced by iron deficiency anemia promoting cardiac fibrosis and lung congestion. Kiris et al proved [12] that Epo significantly decreased (P=0.05 versus aortic IR) the focal renoglomerular necrosis, the Bowman's capsule dilatation, the tubular epithelium degeneration, the tubular epithelium necrosis, interstitial tissues inflammatory cells infiltration and the blood vessels congestion upon aortic IR in rats. Minamishima et al associated [13] the premature mortality with pronounced venous congestion and dilated cardiomyopathy in enzyme PHD2 lack mice.…”

Section: Discussionmentioning

confidence: 98%

The Erythropoietin Effect on Uterus Congestion after Uterine Ischemia Reperfusion

Tsompos¹,

Panoulis²,

Toutouzas³

et al. 2017

Transl Biomed

View full text Add to dashboard Cite

Objective:This experiment investigated the erythropoietin (Epo) effect after uterine ischemiareperfusion (IR) in rats. The effect of Epo was evaluated studying the mean uterine congestion (UC) lesions. Materials and methods:The mean weight of 40 rats used in the study was 247.7 g. The UC lesions were estimated for the groups A and C on 60 min and for the groups B and D on 120 min after reperfusion. Only the groups C and D were administered by Epo.Results: Epo administration non-significantly declined the UC lesions scores by (without lesions) 0.15 (-0.5595137-0.2595137) (p=0.4545). Reperfusion time non-significantly raised the UC lesions scores by (without lesions) 0.15 (-0.5676974-0.3676974) (P=0.5058). However, the combined Epo administration with reperfusion time non-significantly declined the UC lesions scores by (without lesions) 0.0090909 (-0.2577992-0.2396174) (p=0.9414). Conclusions:The Epo administration presented a nonsignificantly declining short-term effect on UC lesions scores. Perhaps, a higher Epo dosage and/or an experimental time lasting longer than 2 hours may reveal more significant efficacies.

show abstract

The Protective Effect of Erythropoietin on Renal Injury Induced by Abdominal Aortic-Ischemia-Reperfusion in Rats

Cited by 40 publications

References 34 publications

Role of Erythropoietin Induced Stem Cell Mobilization in the Repairing of Acute Kidney Injury Following Ischemia Reperfusion in Albino Rats: A Histological Study

Role of Erythropoietin Induced Stem Cell Mobilization in the Repairing of Acute Kidney Injury Following Ischemia Reperfusion in Albino Rats: A Histological Study

Hydrogen Sulfide Reduces Inflammation Following Abdominal Aortic Occlusion in Rats

The Erythropoietin Effect on Uterus Congestion after Uterine Ischemia Reperfusion

Contact Info

Product

Resources

About