2011
DOI: 10.1016/j.gie.2011.01.059
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Erythromycin is preferable to metoclopramide as a prokinetic in acute upper GI bleeding

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Cited by 12 publications
(9 citation statements)
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“…In 2010, the international consensus recommendations by Barkun et al [ 1 ] were published and despite the five published RCTs [ 11 - 13 , 16 , 17 ] and one meta-analysis [ 6 ] on the subject of erythromycin at time, the group recommended that promotility agents should not be routinely used prior to endoscopy in UGIB patients [ 1 ]. However, this recommendation included trials using erythromycin and metoclopramide which likely influenced the outcome consensus as metoclopramide seems to be less effective [ 19 ]. In 2011, two meta-analyses [ 7 , 8 ] were published including only studies using erythromycin and discovered that the use of erythromycin prior to endoscopy increased the odds of adequate gastric visualization while decreasing the odds of a second-look endoscopy.…”
Section: Discussionmentioning
confidence: 99%
“…In 2010, the international consensus recommendations by Barkun et al [ 1 ] were published and despite the five published RCTs [ 11 - 13 , 16 , 17 ] and one meta-analysis [ 6 ] on the subject of erythromycin at time, the group recommended that promotility agents should not be routinely used prior to endoscopy in UGIB patients [ 1 ]. However, this recommendation included trials using erythromycin and metoclopramide which likely influenced the outcome consensus as metoclopramide seems to be less effective [ 19 ]. In 2011, two meta-analyses [ 7 , 8 ] were published including only studies using erythromycin and discovered that the use of erythromycin prior to endoscopy increased the odds of adequate gastric visualization while decreasing the odds of a second-look endoscopy.…”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, Daram et al ., also demonstrated that metoclopramide is inferior to erythromycin infusion before endoscopy for patients with UGIB. [21]…”
Section: Discussionmentioning
confidence: 99%
“…Finally, this meta-analysis evaluated only erythromycin based on the possibility that metoclopramide may not be as effective, which has been our experience and experience of others. [621]…”
Section: Discussionmentioning
confidence: 99%
“…There is a sound rationale for using prokinetics before endoscopy in upper GI bleeding to clear the stomach and improve both the endoscopic views and probably safety. Individual trials have shown inconsistent results, but recent meta-analyses showed that intravenous erythromycin before endoscopy was associated with meaningful clinical benefit in terms of improved mucosal visualisation, reduction in repeat endoscopy, and blood transfused as well as length of stay but that metoclopramide was less effective 34 36 . Erythromycin is probably underused and seems to be a simple intervention that would improve outcomes.…”
Section: Drug Therapymentioning
confidence: 99%