BackgroundIn patients suffering from upper gastrointestinal bleeding (UGIB), adequate visualization is essential during endoscopy. Prior to endoscopy, erythromycin administration has been shown to enhance visualization in these patients; however, guidelines have not fully adopted this practice. Thus, we performed a comprehensive, up-to-date meta-analysis on the issue of erythromycin administration in this patient population.MethodsAfter searching multiple databases (November 2015), randomized controlled trials on adult subjects comparing administration of erythromycin before endoscopy in UGIB patients to no erythromycin or placebo were included. Pooled estimates of adequacy of gastric mucosa visualized, need for second endoscopy, duration of procedure, length of hospital stay, units of blood transfused, and need for emergent surgery using odds ratio (OR) or mean difference (MD) were calculated. Heterogeneity and publication bias were assessed.ResultsEight studies (n=598) were found to meet the inclusion criteria. Erythromycin administration showed statistically significant improvement in adequate gastric mucosa visualization (OR 4.14; 95% CI: 2.01-8.53, P<0.01) while reduced the need for a second-look endoscopy (OR 0.51; 95% CI: 0.34-0.77, P<0.01) and length of hospital stay (MD -1.75; 95% CI: -2.43 to -1.06, P<0.01). Duration of procedure (P=0.2), units of blood transfused (P=0.08), and need for emergent surgery (P=0.88) showed no significant differences.ConclusionPre-endoscopic erythromycin administration in UGIB patients significantly improves gastric mucosa visualization while reducing length of hospital stay and the need for second-look endoscopy.
I solated spontaneous dissection of the celiac artery is reportedly rare, and even rarer when unaccompanied by aortic dissection. We report the finding of an isolated spontaneous dissection of the celiac artery in a patient with von Willebrand disease, and our diagnostic use of computed tomography (CT) and CT angiography in this case. Case ReportIn March 2011, a 47-year-old man was admitted to our hospital because of persistent, dull pain in the upper left quadrant of the abdomen. The pain started after the patient ate, and it gradually worsened. About a week before admission, he had sharp epigastric pain that radiated to his back and lasted for approximately 10 minutes. He reported no fever, nausea, vomiting, rectal bleeding, melena, or dysuria. He had von Willebrand disease, upper gastrointestinal bleeding secondary to nonsteroidal drug use, trigeminal neuralgia, and no history of iatrogenic injury from instrumentation or trauma.The patient's vital signs were stable. Abdominal examination revealed left upper quadrant tenderness without guarding or rigidity. Initial laboratory data included a hemoglobin level of 16.5 g/dL, a white blood cell count of 10,700 cells/mm 3 with a normal differential count, a C-reactive protein level of 4.3 mg/L, an erythrocyte sedimentation rate of 23 mm/hr, and a normal partial thromboplastin time and prothrombin time. Further results were negative for autoimmune disease or vacuities. Contrast-enhanced CT of the abdomen and pelvis revealed an infarct in the posterior third of the spleen (Fig. 1), an opacified segmental branch of a splenic artery, and an eccentric thrombus and focal dissection involving the celiac artery with surrounding fat-stranding (Fig. 2). The dissection was also seen in the common hepatic artery (CHA). Computed tomographic angiograms revealed a normal aorta and an intimal flap within the celiac artery that extended into the splenic artery and the CHA, with small areas of thrombus along the left lateral wall of the celiac artery and the posterior wall of the CHA. The patient was discharged from the hospital on low-dose aspirin therapy, with follow-up CT angiography scheduled in 3 months. DiscussionContrast-enhanced CT is the primary technique for diagnosing celiac artery dissection; magnetic resonance imaging, magnetic resonance angiography, Doppler ultrasonography, and conventional angiography can also be used. On contrast-enhanced CT, findings might include an intimal flap, mural thrombus with or without aneurysmal dilation, segmental stenosis, and infiltration of the fat surrounding the vessel.
Antiarrhythmic drugs are commonly prescribed cardiac drugs. Due to their receptor mimicry with several of the gastrointestinal tract receptors, they can frequently lead to gastrointestinal side effects. These side effects are the most common reasons for discontinuation of these drugs by the patients. Knowledge of these side effects is important for clinicians that manage antiarrhythmic drugs. This review focuses on the gastrointestinal side effects of these drugs and provides a detailed up-to-date literature review of the side effects of these drugs. The review provides case reports reported in the literature as well as possible mechanisms that lead to gastrointestinal side effects.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.