Erythroleukophagocytosis by Leukemic Cells—A Nonspecific Finding

Wheeler, Michael S.; Wilson, Eric C.; Stass, Sanford A.

doi:10.1093/ajcp/75.2.266

Cited by 13 publications

(3 citation statements)

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“…This phenomenon is not considered to distinguish between acute monoblastic leukemia and other type of leukemia. It may also be present in non-hematopoietic malignancies [13].…”

Section: Discussionmentioning

confidence: 99%

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Peripheral Blood Blast Erythrophagocytosis After Chemotherapy in a Patient with Acute Monoblastic Leukemia

Sayagh¹,

Cherrafi²,

Siboub³

et al. 2022

AJLM

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Hemophagocytosis is a property of histiocytic lineage cells; it is rarely performed by leukemic blasts. This phenomenon happens in approximately 1% of acute leukemias, particularly acute myeloid leukemia (AML) and especially those of monoblastic or monocytic lineage. Associations have been found with some chromosomal abnormalities, especially t(8;16). The presence of blast hemophagocytosis may speed-up the diagnosis of some of these cytogenetic abnormalities. We aim to report a case of peripheral blood blast erythrophagocytosis after chemotherapy for the treatment of acute monoblastic leukemia. It is about 29 years old male treated for acute monoblastic leukemia without chromosomal abnormalities at the onset, with two relapses for the first and second induction cures. Peripheral blood smear performed during the follow up showed 73% of blasts, 3.6% of them with erythrophagocytosis. Several genetic abnormalities are known to be associated to leukemic cell hemophagocytosis, involving particularly the chromosome 8 and explaining a part of the leukemogenesis. These abnormalities are rare and associated to a poor prognosis. The mechanism behind this blast behavior is still unclear and authors suggest some hypothesis to explain this phenomenon: the presence of binding receptors involved in phagocytosis on blasts, karyotype instability and evolution during the course of the disease and the involvement of treatment toxicity.

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“…This phenomenon is not considered to distinguish between acute monoblastic leukemia and other type of leukemia. It may also be present in non-hematopoietic malignancies [13].…”

Section: Discussionmentioning

confidence: 99%

“…The percentage of blasts involved may vary extremely, from 0.2 to 36.7% [1,[3][4][5][6][7][8][9]11]. The specificity of blast hemophagocytosis is controversial and cases reported in the literature do not mention any specific explorations or dedicated treatment as in M-HLH [3,11,13].…”

Section: Discussionmentioning

confidence: 99%

Peripheral Blood Blast Erythrophagocytosis After Chemotherapy in a Patient with Acute Monoblastic Leukemia

Sayagh¹,

Cherrafi²,

Siboub³

et al. 2022

AJLM

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“…that some of the opsonized neutrophils are sequestrated while they still remain in the bone marrow. Intramedullary hemophagocytosis is regarded as nonspecific finding and is often observed in hematological malignancies includ ing monocytic leukemia, lymphoma, and malignant histiocytosis [6]. It is also one of the characteristics in virus-associated hemophagocytic syndrome [7], How ever, in none of the disorders listed above, hemophagocytosis of myeloid cells alone has been reported.…”

Section: Discussionmentioning

confidence: 99%

Intramedullary Neutrophil Phagocytosis by Histiocytes in Autoimmune Neutropenia of Infancy

Shimizu

Sawada²,

Katano³

et al. 1990

Acta Haematol

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We describe a case of autoimmune neutropenia of infancy in which active phagocytosis of mature myeloid cells by bone marrow histiocytes was observed. This finding in the routine hematological investigation has not been reported so far and might be helpful in suggesting the diagnosis of autoimmune neutropenia of infancy, and also in understanding the pathogenesis of peripheral neutropenia in this disease.

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Hemophagocytosis by leukemic blasts in 7 acute myeloid leukemia cases with t(16;21)(p11;q22)

Imashuku

Hibi

Shinoda

et al. 2000

Cancer

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Erythroleukophagocytosis by Leukemic Cells—A Nonspecific Finding

Cited by 13 publications

References 0 publications

Peripheral Blood Blast Erythrophagocytosis After Chemotherapy in a Patient with Acute Monoblastic Leukemia

Peripheral Blood Blast Erythrophagocytosis After Chemotherapy in a Patient with Acute Monoblastic Leukemia

Intramedullary Neutrophil Phagocytosis by Histiocytes in Autoimmune Neutropenia of Infancy

Hemophagocytosis by leukemic blasts in 7 acute myeloid leukemia cases with t(16;21)(p11;q22)

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