Erythroid microRNA and oxidant status alterations in l-thyroxine-induced hyperthyroid rats: effects of selenium supplementation

Bahtiyar, Nurten; Yoldaş, Aysun; Abbak, Yavuz; Dariyerli, Nuran; Toplan, Selmin

doi:10.23736/s2724-6507.20.03154-5

Cited by 5 publications

(4 citation statements)

References 30 publications

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“…Гемолиз остается значимым фактором при выпол нении исследований в пробах крови и вне зависимости от причины возникновения является основным крите рием отбраковки образцов для проведения исследова ния в клинической лабораторной диагностике. При ге молизе из разрушенных эритроцитов в плазму попадают внутриклеточные микроРНК, которые смещают про филь обнаруживаемых при исследовании свободно цир кулирующих микроРНК [88].…”

Section: важность преаналитической фазы в спортивной медицинеunclassified

Preanalytical features of the determination of circulating microRNAs as new specific biomarkers of the body’s response to physical activity

Postnikov

Пронина

2021

jour

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MicroRNAs are small non-coding single-stranded RNAs, 18 to 25 nucleotides long, they regulate gene expression at the post-transcriptional level through specific binding to the target mRNA, leading to its degradation. In recent decades, the development of technologies for determining the expression profiles of miRNAs has become an important part of research projects, and the role of miRNAs as potential highly informative molecular biomarkers of various physiological and pathological processes in the body is actively explored by the scientific community. In particular, physical activity is an important modifying factor for circulating miRNAs. Unlike classical blood biochemical parameters, which can change over time depending on the temperature and storage conditions of the sample, microRNAs remain stable during storage and even after multiple freeze-thaw cycles, which makes them an attractive and easily accessible target for detection. However, the determination of the microRNA expression profile in clinical practice is still difficult due to the high heterogeneity of analytical procedures used for testing. In sports medicine, the preanalytical stage is especially important, since often the conditions for sampling are not standardized and can affect the analysis result. This review shows the role of miRNAs as new sensitive biomarkers of the effectiveness of the training process and regulators of the body’s response to physical activity, and also discusses some preanalytical aspects of the analysis of miRNA expression profiles.

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Section: важность преаналитической фазы в спортивной медицинеunclassified

Preanalytical features of the determination of circulating microRNAs as new specific biomarkers of the body’s response to physical activity

Postnikov

Пронина

2021

jour

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“…This can be blocked by discontinuing the use of L‐thyroxin or using β–blockers, such as propranolol, atenolol, and metoprolol 31 . Various animal studies indicated that L‐thyroxin‐induced hyperthyroidism resulted in the increased levels of malondialdehyde and glutathione in rat brain tissue, which further activated the oxidant and anti‐oxidant system 32,33 . However, excessive lipid peroxidation was thought to be a hallmark of most neurodegenerative diseases, such as PD 34 .…”

Section: Introductionmentioning

confidence: 99%

“… 31 Various animal studies indicated that L‐thyroxin‐induced hyperthyroidism resulted in the increased levels of malondialdehyde and glutathione in rat brain tissue, which further activated the oxidant and anti‐oxidant system. 32 , 33 However, excessive lipid peroxidation was thought to be a hallmark of most neurodegenerative diseases, such as PD. 34 In addition, the incidence of hypothyroidism and hyperthyroidism in L‐thyroxin‐treated PD patients was exhibited to be higher than that in the control group, and hyperthyroidism was also closely associated with higher PD risk.…”

Section: Introductionmentioning

confidence: 99%

New hope for Parkinson's disease treatment: Targeting gut microbiota

2022

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Parkinson's disease (PD) is one of the common neurodegenerative diseases, with more than 10 million confirmed cases of PD estimated worldwide by 2040. 1 Tremor, rigidity, and bradykinesia are typical clinical manifestations of PD. 2 Non-motor symptoms include gastrointestinal dysfunction, such as constipation, sleep behavior disorder, depression, and cognitive impairment. 3 Importantly, nonmotor symptoms and motor symptoms might influence each other to aggravate PD severity, 4 thereby exacerbating the deterioration of quality of life and mentality in patients with PD.The pathogenesis of PD is complex, which is mainly related to complex environmental factors. A large number of epidemiological studies indicated that the prevalence of PD was higher in people over 50 years old, and the incidence increased with age. 5 The prevalence of PD was higher in men than that in women at the same age. 6 However, there were significant differences in PD prevalence among different regions and races in different studies. [7][8][9] In addition,

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“…Гормоны щитовидной железы контролируют скорость метаболизма и клеточного дыхания, они связаны с окислительным стрессом своим воздействием на антиоксидантные системы организма. Окислительный стресс, вызванный активными формами кислорода, способствует развитию сердечно-сосудистых заболеваний, диабета и почечной недостаточности [47].…”

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Functional and Morphological State of the Kidneys in Hypo-and Hyperthyroidism

Nanieva,

Khutugova,

Dzhioev

et al. 2023

СПНО (MPSE)

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The thyroid gland is one of the most important human organs, since the hormones it produces, in particular triand tetraiodothyronine, are involved in the regulation of many physiological processes, and any dysfunction in the synthesis and secretion of these biologically highly active substances can cause various disorders throughout the body, especially in the processes, which are associated with metabolism and basal metabolism. The effect of iodinecontaining thyroid hormones on kidney function in conditions of their pathology, in particular chronic insufficiency, is currently insufficiently studied. And since the kidneys are aerobic organs and require a significant amount of oxygen for their normal functioning, they become target organs for the action of both excess and lack of thyroid hormones. The information obtained from this article will help expand clinical knowledge, ensure timely diagnosis and conduct the right treatment tactics to increase the life expectancy and survival of patients with chronic kidney disease in hypo-and hyperthyroidism. This review has focused on the studies and findings related to impaired renal function in hypothyroidism and hyperthyroidism. The search for articles, most of which were published in the last 7 years, was carried out in the electronic bibliographic databases e-library, Scopus, Web of Science, Google scholar and PubMed.

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Erythroid microRNA and oxidant status alterations in l-thyroxine-induced hyperthyroid rats: effects of selenium supplementation

Cited by 5 publications

References 30 publications

Preanalytical features of the determination of circulating microRNAs as new specific biomarkers of the body’s response to physical activity

Preanalytical features of the determination of circulating microRNAs as new specific biomarkers of the body’s response to physical activity

New hope for Parkinson's disease treatment: Targeting gut microbiota

Functional and Morphological State of the Kidneys in Hypo-and Hyperthyroidism

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