BACKGROUND: Erythroderma, characterized by generalized erythema and scaling involving more than 90% of the body surface area, poses a significant risk of morbidity and mortality. Thorough clinical and laboratory investigations may not detect the underlying causes many a times. Herein lays the importance of histopathology. OBJECTIVES: a) To study the aetiology of erythroderma b) To evaluate the clinicopathological profile of erythroderma. METHODOLOGY: during a 1 year study period from June 2013 to May 2014, 52 patients with erythroderma were evaluated to study the aetiology and demographic profile in Silchar Medical College and Hospital. RESULTS: The male female ratio was 4.2:1.The largest number of cases was found in the 6 th decade of life. Preexisting dermatoses comprised of 57.69% cases, drugs comprised of 13.46% cases, malignancy was found to be the cause in 1.92% cases, while 26.92% cases were idiopathic. Psoriasis amongst the preexisting dermatoses, was the most common cause (25%). CONCLUSION: All 52 cases were subjected to histopathology. Histopathology helped in correlating & confirming the aetiology of erythroderma in 38 cases (73.07%) and did not help in 14 cases (26.92%).