Histoid leprosy is an uncommon variant of lepromatous leprosy characterized by unique histopathological findings and characteristic bacterial morphology. It occurs in patients relapsing after dapsone monotherapy, in the presence of dapsone resistance or at times de novo. Though it is commonly seen in lepromatous leprosy, very rarely it may be seen in borderline and indeterminate leprosy. We report here a case of de novo histoid leprosy with borderline tuberculoid leprosy because of its rarity.
BACKGROUND: Erythroderma, characterized by generalized erythema and scaling involving more than 90% of the body surface area, poses a significant risk of morbidity and mortality. Thorough clinical and laboratory investigations may not detect the underlying causes many a times. Herein lays the importance of histopathology. OBJECTIVES: a) To study the aetiology of erythroderma b) To evaluate the clinicopathological profile of erythroderma. METHODOLOGY: during a 1 year study period from June 2013 to May 2014, 52 patients with erythroderma were evaluated to study the aetiology and demographic profile in Silchar Medical College and Hospital. RESULTS: The male female ratio was 4.2:1.The largest number of cases was found in the 6 th decade of life. Preexisting dermatoses comprised of 57.69% cases, drugs comprised of 13.46% cases, malignancy was found to be the cause in 1.92% cases, while 26.92% cases were idiopathic. Psoriasis amongst the preexisting dermatoses, was the most common cause (25%). CONCLUSION: All 52 cases were subjected to histopathology. Histopathology helped in correlating & confirming the aetiology of erythroderma in 38 cases (73.07%) and did not help in 14 cases (26.92%).
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