Erythrocytosis as the first manifestation of adrenal carcinoma

Cannavò, Laura; Zirilli, Giuseppina; Lima, Mario; Iaria, Graziella; Luca, Filippo De; Valenzise, Mariella

doi:10.1002/pbc.27685

Cited by 2 publications

(1 citation statement)

References 19 publications

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“…Primary erythrocytosis is the EPOR mutation, a primary congenital entity, and also polycythemia vera, an acquired disease. On the other hand, the acquired secondary etiologies are divide into two groups, those where EPO increase with hypoxia, such as chronic pulmonary disease, hypoventilation syndromes, right to left cardiopulmonary communication, carbon monoxide chronic intoxication, renal artery stenosis and polycystic kidney disease, and without hypoxia, like EPO producing tumors as clear and chromophobe cell renal, hepatocellular, adrenal and parathyroid carcinomas and cerebellar hemangioblastoma among others [7][8][9][10][11].…”

Section: Discussionmentioning

confidence: 99%

Paraneoplastic Erythrocytosis: First Manifestation of a Large Hepatocellular Carcinoma Successfully Treated by Radical Liver Resection and Adjuvant Thalidomide

Peña¹,

Artigas²,

Hudson³

et al. 2020

AJSCR

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The paraneoplastic syndromes occur in upto 28% of patients with hepatocellular carcinoma (HCC). Among them, erythrocytosis is reported as just 3.9 % of frequency. We describe a 59-year-old male patient with a large HCC in a non-cirrhotic liver presenting with erythrocytosis. Four phlebotomies were performed before radical surgical resection. Extended right hepatectomy was undertaken, proving a unifocal 10.2 X 13 X 6.5 cm, extensively necrotic HCC. There were no postoperative complications, and the patient was discharged on the 6th postoperative day. Adjuvant treatment with thalidomide was indicated for 36 months. We observed a progressive decrease in haemoglobin, haematocrit, EPO, and AFP to normal levels after the surgical procedure. A periodic follow-up with laboratory parameters and CT scan was done for 46 months with no evidence of relapses, until now. This case highlights a rare manifestation of advanced liver cancer; the first documented paraneoplastic erythrocytosis in a large HCC case in Chile was successfully treated by radical liver resection and adjuvant thalidomide.

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