The paraneoplastic syndromes occur in upto 28% of patients with hepatocellular carcinoma (HCC). Among
them, erythrocytosis is reported as just 3.9 % of frequency. We describe a 59-year-old male patient with a
large HCC in a non-cirrhotic liver presenting with erythrocytosis. Four phlebotomies were performed before
radical surgical resection. Extended right hepatectomy was undertaken, proving a unifocal 10.2 X 13 X 6.5
cm, extensively necrotic HCC. There were no postoperative complications, and the patient was discharged
on the 6th postoperative day. Adjuvant treatment with thalidomide was indicated for 36 months. We
observed a progressive decrease in haemoglobin, haematocrit, EPO, and AFP to normal levels after the
surgical procedure. A periodic follow-up with laboratory parameters and CT scan was done for 46 months
with no evidence of relapses, until now. This case highlights a rare manifestation of advanced liver cancer;
the first documented paraneoplastic erythrocytosis in a large HCC case in Chile was successfully treated by
radical liver resection and adjuvant thalidomide.
International recommendations during the COVID-19 change favoring medical management and open surgical approach of acute appendicitis.
During COVID times, the presence of appendicular peritonitis was doubled.
The collateral damage of the COVID pandemic has not yet been fully evaluated.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.