Erythrocytic Sedimentation Rate as a Measure of Clinical Activity in Inflammatory Bowel Disease

Sachar, David B.; Smith, Harry; Chan, Simon; Cohen, Lawrence B.; Lichtiger, Simon; Messer, Julio

doi:10.1097/00004836-198612000-00011

Cited by 72 publications

(35 citation statements)

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“…Furthermore, sTREM-1 performed well as a marker of disease activity irrespective of disease location in UC. In contrast, ESR showed a good correlation with disease activity only in left-sided and extensive colitis, but not proctosigmoiditis, which is similar to the results of previous studies [24]. These findings indicate that sTREM-1 could be a quite sensitive marker reflecting disease activity even in remitted disease status that has a potential for relapse and limited localized extent of disease.…”

Section: Discussionsupporting

confidence: 89%

Correlation of Serum-Soluble Triggering Receptor Expressed on Myeloid Cells-1 with Clinical Disease Activity in Inflammatory Bowel Disease

et al. 2008

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Although triggering receptor expressed on myeloid cells-1 (TREM-1) has recently been shown to be upregulated in the intestines of patients with inflammatory bowel disease (IBD), it remains unclear whether serum-soluble TREM-1 (sTREM-1) level reflects disease activity in patients with IBD. This study aimed to evaluate the correlation of sTREM-1 level with disease activity in IBD. We prospectively enrolled consecutive patients with IBD and assessed their clinical disease activity using the guidelines of the American College of Gastroenterology. At the time that disease activity was assessed, sTREM-1 level (using an enzyme-linked immunosorbent assay method) and other laboratory findings including erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were also measured. A total of 31 patients with ulcerative colitis (UC) and 22 with Crohn's disease (CD) were enrolled. The mean sTREM-1 level in patients with either UC (60.4 +/- 41.8 pg/ml) or CD (66.5 +/- 42.4 pg/ml) was significantly higher than in healthy controls (0.6 +/- 1.4 pg/ml) (P = 0.003 and P = 0.002, respectively). In patients with UC, sTREM-1 level was more highly correlated with disease activity (r = 0.849) than was ESR (r = 0.619) or CRP level (r = 0.546). Moreover, sTREM-1 level correlated well with disease activity irrespective of disease extent. In patients with CD, sTREM-1 level was lower in those with remission compared with those without (46.8 +/- 35.3 pg/ml versus 77.8 +/- 43.1 pg/ml), but this trend did not reach statistical significance (P = 0.100). The results of our study suggest that sTREM-1 could be a potential marker for disease activity in IBD patients, especially those with UC.

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Section: Discussionsupporting

confidence: 89%

Correlation of Serum-Soluble Triggering Receptor Expressed on Myeloid Cells-1 with Clinical Disease Activity in Inflammatory Bowel Disease

et al. 2008

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“…In these individuals, CRP concentrations might be especially low [19, 20]. However, due to the fact that only a few patients were included in this category, they probably did not have a major effect on the results of the whole cohort.…”

Section: Discussionmentioning

confidence: 99%

Correlated Expression of High-Sensitivity C-Reactive Protein in Relation to Disease Activity in Inflammatory Bowel Disease: Lack of Differences between Crohn’s Disease and Ulcerative Colitis

Zilberman¹,

Maharshak²,

Arbel³

et al. 2006

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Background/Aims: As opposed to regular C-reactive protein (CRP) assays, the introduction of high-sensitivity ones has enabled us to detect low grade inflammation in patients with inflammatory bowel disease (IBD). We addressed the subject of the degree of correlation between the concentration of high-sensitivity CRP (hs-CRP) and the inflammatory IBD activity score. Methods: Included were 90 patients with Crohn’s disease (CD), 70 with ulcerative colitis (UC) and 160 controls. Disease activity was determined using CD activity index (CDAI) for CD and Mayo score for UC. The Dade Boering BNII Nephelometer was used to determine the hs-CRP concentrations. Results: The coefficient of correlation between hs-CRP and the disease activity score was similar for both UC (0.26) and CD (0.36). Conclusions: These findings are relevant for therapeutic intervention in which a greater absolute reduction in the hs-CRP concentration in CD patients (who generally present higher CRP concentrations than those found in UC) might be interpreted as a better response compared to the same absolute reduction in UC patients. This information is needed for clinicians using the hs-CRP assay to estimate IBD disease activity in daily practice.

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“…However, it lacks high accuracy as it is influenced by both the morphology and the number of erythrocytes and by other plasma components, such as immunoglobulin (7). Given the large variation in the concentration of plasma proteins in patients with IBDs and the long half-life, ESR does not reflect the clinical condition; the decrease in ESR can take several days, even if there is a rapid and proven clinical improvement (8). Therefore, ESR only roughly assesses the disease activity.…”

Section: Introductionmentioning

confidence: 99%

A rapid test for assessing disease activity in ulcerative colitis

Dranga

Mihai²,

Drug³

et al. 2020

Turk J Gastroenterol

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Erythrocytic Sedimentation Rate as a Measure of Clinical Activity in Inflammatory Bowel Disease

Cited by 72 publications

References 0 publications

Correlation of Serum-Soluble Triggering Receptor Expressed on Myeloid Cells-1 with Clinical Disease Activity in Inflammatory Bowel Disease

Correlation of Serum-Soluble Triggering Receptor Expressed on Myeloid Cells-1 with Clinical Disease Activity in Inflammatory Bowel Disease

Correlated Expression of High-Sensitivity C-Reactive Protein in Relation to Disease Activity in Inflammatory Bowel Disease: Lack of Differences between Crohn’s Disease and Ulcerative Colitis

A rapid test for assessing disease activity in ulcerative colitis

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