A rapid test for assessing disease activity in ulcerative colitis

Dranga, Mihaela; Mihai, Cătălina; Drug, Vasile; Dumitrescu, Gabriela; Prelipcean, Cristina Cijevschi

doi:10.5152/tjg.2016.15408

Cited by 7 publications

(4 citation statements)

References 17 publications

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“…Therefore, we concluded that PGE-MUM reflects endoscopic scores with greater accuracy than CRP does, especially during exacerbations (increase in endoscopic score). Some studies reported the usefulness of CRP as a biomarker for UC; these studies defined MES 0 or 1 as MH, similar to the findings of our study 38 – 41 . In our previous cross-sectional study, MES 0, 1 was defined as MH, and receiver operating characteristic analysis of PGE-MUM to predict MH showed that the cut-off value was 30.9 μg/g·Cr and the area under the curve was 0.644 (95% CI 0.523–0.765), with a sensitivity of 48.5% and specificity of 78.0% 26 .…”

Section: Discussionsupporting

confidence: 90%

Comparison between Prostaglandin E-major urinary metabolite and C-reactive protein levels to reflect endoscopic scores in patients with ulcerative colitis

Ishida

Tamura

Miyazu

et al. 2021

Sci Rep

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Prostaglandin E-major urinary metabolite (PGE-MUM) and C-reactive protein (CRP) are useful biomarkers in patients with ulcerative colitis. However, whether changes in endoscopic scores over time are reflected in the values of these biomarkers has not been verified. This prospective observational study aimed to assess the relationship between changes in biomarker levels and endoscopic scores in patients with ulcerative colitis. A total of 100 colonoscopy intervals of patients with ulcerative colitis were enrolled. The relationship between variations in the Mayo endoscopic subscore over time and the accompanying changes in biomarker values were investigated. PGE-MUM levels showed a significant rise in the increased endoscopic score group (P = 0.007) and a decrease with reduced endoscopic score group (P = 0.023). CRP levels showed a significant decline with lower endoscopic values (P < 0.001); however, there was no corresponding increase with higher endoscopic scores (P = 0.141). Biomarker levels remained unchanged with stable endoscopic scores (P = 0.090 and P = 0.705). PGE-MUM levels varied significantly, and corresponded to the mucosal healing state (P = 0.019 and P = 0.009). The correlation between changes in PGE-MUM and the endoscopic score was stronger than that for CRP (r = 0.518, P < 0.001 vs. r = 0.444, P < 0.001, respectively). PGE-MUM reflected changes in endoscopic scores more accurately than CRP.

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Section: Discussionsupporting

confidence: 90%

Comparison between Prostaglandin E-major urinary metabolite and C-reactive protein levels to reflect endoscopic scores in patients with ulcerative colitis

Ishida

Tamura

Miyazu

et al. 2021

Sci Rep

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“…Among them, fecal calprotectin (FC) proved to be the best, achieving highest prediction accuracies. FC is a non-invasive and repeatable marker that has been demonstrated to have a good correlation with disease activity, and even to have the ability of indicating mucosal healing in patients with UC [20].…”

Section: Discussionmentioning

confidence: 99%

Laboratory Data and IBDQ—Effective Predictors for the Non-Invasive Machine-Learning-Based Prediction of Endoscopic Activity in Ulcerative Colitis

Gavrilescu

Popa

Dranga

et al. 2023

JCM

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A suitable, non-invasive biomarker for assessing endoscopic disease activity (EDA) in ulcerative colitis (UC) has yet to be identified. Our study aimed to develop a cost-effective and non-invasive machine learning (ML) method that utilizes the cost-free Inflammatory Bowel Disease Questionnaire (IBDQ) score and low-cost biological predictors to estimate EDA. Four random forest (RF) and four multilayer perceptron (MLP) classifiers were proposed. The results show that the inclusion of IBDQ in the list of predictors that were fed to the models improved accuracy and the AUC for both the RF and the MLP algorithms. Moreover, the RF technique performed noticeably better than the MLP method on unseen data (the independent patient cohort). This is the first study to propose the use of IBDQ as a predictor in an ML model to estimate UC EDA. The deployment of this ML model can furnish doctors and patients with valuable insights into EDA, a highly beneficial resource for individuals with UC who need long-term treatment.

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“…In routine clinical practice, regular assessments of disease activity can help ensure that treatment goals are met, the patient is receiving the most appropriate therapy, and the risk of complications is monitored. Endoscopic evaluation has been described in the literature as the gold standard for disease monitoring in UC [4, 5]. However, its invasive nature and the associated cost and patient burden limit the frequency that endoscopy can practically be performed [5, 6].…”

Section: Introductionmentioning

confidence: 99%

“…Endoscopic evaluation has been described in the literature as the gold standard for disease monitoring in UC [4, 5]. However, its invasive nature and the associated cost and patient burden limit the frequency that endoscopy can practically be performed [5, 6].…”

Section: Introductionmentioning

confidence: 99%

Remote Monitoring of Patient-Reported Outcomes in Ulcerative Colitis: A Prospective Real-World Pilot Study

Sebastian

Roberts

Waller

et al. 2019

PharmacoEconomics Open

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Introduction The 6-point version of the Mayo score relies on two patient-reported outcomes (PRO2): stool frequency and rectal bleeding. We assessed the feasibility and acceptability of remote online PRO2 reporting for golimumab-treated ulcerative colitis (UC) patients. Patients and Methods This was a UK-based, multi-centre, prospective, real-world, non-interventional pilot study. Eligible patients completed PRO2 scores at baseline and every 4 weeks over a period of 6 months. Demographics were collected at baseline and a satisfaction questionnaire was completed at study end. Each patient provided data anonymously via an online platform. Results Fifty-two patients enrolled in the study. Mean (SD) patient age was 40.8 (13.6); 52% were male. Patients provided data on a personal computer (44%), mobile phone (38%) or tablet (18%). Forty-seven (90%) patients completed the baseline questionnaire within the accepted time range. Subsequent scores were reported on time by eligible patients with a success rate of 94%, 92%, 90%, 87%, 90% and 81% at end of months 1–6, respectively. Conclusions Remote monitoring of PRO2 in UC was feasible amongst the sample tested. Of those initially willing to provide data in this way, attrition was low. Formal roll-out of this system could be used to support a more frequent assessment of UC symptoms without over-burdening the healthcare system. Electronic supplementary material The online version of this article (10.1007/s41669-019-0121-8) contains supplementary material, which is available to authorized users.

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A rapid test for assessing disease activity in ulcerative colitis

Cited by 7 publications

References 17 publications

Comparison between Prostaglandin E-major urinary metabolite and C-reactive protein levels to reflect endoscopic scores in patients with ulcerative colitis

Comparison between Prostaglandin E-major urinary metabolite and C-reactive protein levels to reflect endoscopic scores in patients with ulcerative colitis

Laboratory Data and IBDQ—Effective Predictors for the Non-Invasive Machine-Learning-Based Prediction of Endoscopic Activity in Ulcerative Colitis

Remote Monitoring of Patient-Reported Outcomes in Ulcerative Colitis: A Prospective Real-World Pilot Study

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