Erythrocyte Sedimentation Rate and Age

Hayes, Gerry S.; Stinson, Iva N.

doi:10.1001/archopht.1976.03910030473007

Cited by 48 publications

(16 citation statements)

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“…Previous studies have demonstrated an upward trend of values of nonspecific markers of inflammation such as ESR (abnormal in 25%-45% of those older than 50) and CRP (abnormal in 10%-30% of those older than 50). 17,18 Importantly, abnormal rheumatologic tests rarely changed the etiology or management of these patients. All 7 of the patients where the test was informative had warning signs of an atypical neuropathy, a rare neuropathy subtype, or known rheumatologic disease.…”

Section: Discussionmentioning

confidence: 99%

Value of thyroid and rheumatologic studies in the evaluation of peripheral neuropathy

et al. 2013

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SummaryPeripheral neuropathy is a common disorder, often prompting an extensive initial laboratory evaluation. The initial evaluation is particularly challenging to primary care physicians and neurologists because of the broad differential diagnosis. Although screening thyroid and rheumatologic tests are frequently ordered, the diagnostic yield of these tests is unclear. Data from our institution were collected on patient demographics, clinical characteristics including warning signs suggestive of a diagnosis other than distal symmetric polyneuropathy, history of thyroid or rheumatologic disease, and laboratory tests ordered. Thyroid and rheumatologic screening tests are commonly ordered in the evaluation of peripheral neuropathy. Our findings suggest a low aggregate value of these tests based on low yield and infrequent changes in the suspected etiology or management of these patients. P eripheral neuropathy encompasses a heterogeneous group of disorders, including distal symmetric polyneuropathy, multiple mononeuropathies, and demyelinating neuropathies, among many others. Peripheral neuropathy is a prevalent condition affecting approximately 2% of the general population and as many as 8% of those over the age of 55.1,2 Distal symmetric polyneuropathy (DSP) is the most frequently encountered form of peripheral neuropathy, typically presenting symmetrically in the feet with pain, *These authors contributed equally to this work.

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Section: Discussionmentioning

confidence: 99%

Value of thyroid and rheumatologic studies in the evaluation of peripheral neuropathy

et al. 2013

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“…Westergren ESR's generally tend to be higher than Wintrobe ones (Hayes & Stinson, 1976) because the Westergren tube is longer, and sedimentation in it is less retarded by packing of cells (Wintrobe et al, 1974). In patients older than 50 years, Westergren's (1924) norms for the ESR have been challenged.…”

Section: Erythrocyte Sedimentation Rate (Esr)mentioning

confidence: 99%

“…However, all authors agree that an ESR greater than 40 mm/hour in a non-anemic person of any age is pathologic. The mean ESR tends to increase (Hayes & Stinson, 1976). Mannik & Gilliland (1977), Jampel (1966), Fitzgerald & Morris (1967), Cogan (1974), Smith & Goldhammer (1975), Simmons & Cogan (1962), Wagener & Hollenhorst (1958), Andrews (1966), and Morris (1977) stated that the ESR is elevated during active stages of temporal arteritis.…”

Section: Erythrocyte Sedimentation Rate (Esr)mentioning

confidence: 99%

Controversies regarding Giant cell (Temporal, Cranial) arteritis

Eshaghian

1979

Doc Ophthalmol

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It is important to establish the diagnosis of temporal arteritis because the disease is treatable; treatment may prevent blindness and even death. Temporal arteritis usually occurs in people older than 51 years of age, although very rarely, histologically documented disease occurs in younger people. The onset may be occult, so that there are few findings. A multitude of signs and symptoms may occur such as fever, headaches, malaise, weight loss, anemia, stroke, cranial nerve palsies, polymyalgia rheumatica, aortitis and other large vessel involvement. The eye may suffer from ischemic optic neuropathy (anterior or posterior), central or cilio-retinal arterial occlusion, ophthalmic artery ischemia, or extraocular muscle palsies. An arterial biopsy showing giant cell arteritis establishes the diagnosis. However, a negative biopsy does not rule out the disease because of the occasional presence of skip areas. Arteriography has only rarely yielded a positive temporal artery biopsy when the initial biopsy done elsewhere was negative. As a diagnostic parameter, the erythrocyte sedimentation rate is nonspecific, being elevated in diseases other than temporal arteritis and sometimes being falsely lowered by technical factors. Furthermore, the temporal artery biopsy is occasionally positive despite a normal erythrocyte sedimentation rate. Treatment is aimed at relieving the patient's symptoms and normalizing the erythrocyte sedimentation rate. Because of the wide spectrum of clinical and laboratory finding in temporal arteritis, no one specific treatment regimen with systemic corticosteroids works for all patients. Temporal arteritis is a well known disease of the elderly which ir rarely fatal but results in significant visual morbidity (Hinzpeter & Naumann, 1976; Spencer & Hoyt, 1960). Since Hutchinson's (1890) description, more than a thousand articles have been written on the subject (Cohen & Smith, 1974). Despite this, many unanswered questions and controversies remain concerning the diagnosis, prognosis and treatment of temporal arteritis. My goal is to review these questions and areas of controversy.

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“…Dicha relación se ve afectada por la viscosidad del plasma, la cual aumenta al aumentar la cantidad de dichas proteínas 4 . Asimismo, se ve afectada por otros factores como la edad, género, anemia, peso corporal y tasa de filtrado glomerular 5,8 . Debido a su baja especificidad, la utilización de la VHS como herramienta diagnóstica ha sido discutida 9 .…”

Section: Introductionunclassified