Erythrocyte rheology and oxygen transfer in microcirculatory system

Maeda, Nobuji

doi:10.17106/jbr.29.2

Cited by 3 publications

(3 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In time-dependent phenomenon, erythrocytes aggregation are induced immediately after the implementation of a low shear condition and the resultant aggregates are dispersed mechanically under high shear stress [23]. Depending on the geometry and hydrodynamic conditions of the flow, there is a transient change of flow behavior and blood viscosity.…”

Section: Resultsmentioning

confidence: 99%

Micro-Needle with Polygonal Structure of Micro-Channel for Stress and Blood or Drug Flow Optimization

Ibrahim

Yunos

Watanabe

et al. 2017

View full text Add to dashboard Cite

Abstract. This paper presents micro-needle with different tip and inner structure of the needle for optimizations of pain stresses and drug or blood deliveries. The micro-needle comes with several design's parameters of length ranging from 5mm to 50mm and diameter ranging from 100µm to 200µm. A hollow micro-needle with four different tip designs which are 10°, D3-2, D6 and Quadruple are also designed to optimize the pain stresses parameters. In order to improve the flow deliveries, the inner structure of the channel is modified into various polygonal shape which is square, hexagon and dodecagon. It shows that, having less contact surface area between the skin and micro-needle's tip and polygonal shape of inner channel has better performance for both of the objectives. These feasible region of average velocity and stress of the micro-needle have satisfied in determining the best design for tip and inner channel of the micro-needle under certain conditions and constraints. The three-dimensional geometry study had improved the insertions performance and efficiencies in painless drug or blood deliveries.

show abstract

Section: Resultsmentioning

confidence: 99%

Micro-Needle with Polygonal Structure of Micro-Channel for Stress and Blood or Drug Flow Optimization

Ibrahim

Yunos

Watanabe

et al. 2017

View full text Add to dashboard Cite

show abstract

“…56 Realizing the fundamental function of RBCs in oxygen transport, Tateishi et al 57,58 were the first to postulate on the correlation between RBC aggregation and O 2 release from erythrocytes and its impact on the sO 2 . 59 In addition, the relation between RBC aggregation and the sO 2 was theoretically and experimentally investigated through in vitro PA imaging by our group. 41 Similar to the Tateishi's findings and our in vitro experiments, the in vivo results in this work demonstrate the impact of RBC aggregation on the sO 2 measurement.…”

Section: Effect Of Rbc Aggregation On Pa Power As a Function Of Absormentioning

confidence: 99%

In vivo photoacoustic assessment of the oxygen saturation changes in the human radial artery: a preliminary study associated with age

2021

View full text Add to dashboard Cite

Significance: We demonstrate the potential of probing the sO 2 change under blood flow in vivo using photoacoustic (PA) imaging and sheds light on the complex relationship between RBC aggregation and oxygen delivery. Aim: To conduct in vivo assessments of the sO 2 in the radial artery of healthy volunteers and simultaneously probe the relation between the sO 2 and hemodynamic behavior such as red blood cell (RBC) aggregation. Approach: The effects of PA-based measurements of blood hemodynamics were studied as a function of the subjects' age (20s, 30s, and 40s). The pulsatile blood flow in the human radial artery of 12 healthy subjects was imaged in the 700 to 900 nm optical wavelength range using a linear array-based PA system. Results: The PA power when blood velocity is minimum (Pa max) was larger than the one attained at maximum blood velocity (Pa min), consistent with predictions based on the cyclical variation of RBC aggregation during pulsatile flow. The difference between Pa min and Pa max at 800 nm (ΔPa 800) increased with age (1.7, 2.2, and 2.6 dB for age group of 20s, 30s, and 40s, respectively). The sO 2 computed from Pa max was larger than the one from Pa min. Conclusions: The ΔPa 800 increased with participant age. The ΔPa 800 metric could be a surrogate of noninvasively monitoring the age-induced changes in RBC aggregation. The sO 2 change during a cycle of pulsatile blood flow also increased with age, demonstrating that RBC aggregation can affect the sO 2 change.

show abstract

“…In post-traumatic period, the quickest interrelated changes with oxygen status, hemorheology, acid—basis and water-electrolytic states take place [ 7 ]. Great influence on perfusion and brain oxygenation in early post-traumatic period is caused by micro-rheological blood defection [ 8 ], which define its fluidity on capillary level and depend on form, sizes and also erythrocyte membrane condition [ 9 ]. It is also known that in the basis of pathological changes, appearing at TBI, there is an activation of free radical oxidation processes, parallel with the decrease in antioxidant protection system activity [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

The functional indexes of RBCs and microcirculation in the traumatic brain injury with the action of 2-ethil-6-methil-3-hydroxypiridin succinate

et al. 2021

View full text Add to dashboard Cite

Research aim To study the RBCs functional and metabolic parameters and the microcirculatory brain structure at traumatic brain injury (TBI) under the action of 2-ethyl-6-methyl-3-hydroxypyridine succinate. Methods A closed TBI was modeled by the free fall of a load on the parietooccipital regions of head. We made studies of the influence of 2-ethil-6-methil-3-hydroxipiridin succinate on aggregation and electrophoretic mobility of RBCs, catalase activity, malonic dialdehyde concentration, adenosine triphosphate and 2.3-biphosphoglycerate (2.3 – BPG) concentrations in RBCs. The state of parenchyma and microcirculatory brain mainstream in post-traumatic period of TBI have been studied on micro-preparations. Results The use of 2-ethyl-6-methyl-3-hydroxypyridine succinate under conditions of head injury leads to a decrease in MDA concentration and in aggregation of RBCs, to an increase in the 2.3—BPG concentration and RBC electrophoretic mobility compared to the control (group value). The most pronounced changes under the action of 2-ethyl-6-methyl-3-hydroxypyridine succinate were observed 3–7 days after the TBI. Significant indicators of the restoration of the microvasculature and brain tissue provoked by the use of 2-ethyl-6-methyl-3-hydroxypyridine succinate of were evident from the 7th day unlike the control group, where the restoration of structural morphological parameters was observed only on the 12th day of the post-traumatic period. Fast recovery of blood flow under the action of 2-ethyl-6-methyl-3-hydroxypyridine succinate ensured effective restoration of neurons and glia in comparison with the control group. Conclusions Early and long-term cytoprotective correction intensifies the oxygen transport function of the blood, prevents and / or reduces disorders of microvessels, neurons and glia in the post-traumatic period, thereby provides correction of hypoxic state and drives to the restoration of brain tissues homeostasis.

show abstract

Erythrocyte rheology and oxygen transfer in microcirculatory system

Cited by 3 publications

References 19 publications

Micro-Needle with Polygonal Structure of Micro-Channel for Stress and Blood or Drug Flow Optimization

Micro-Needle with Polygonal Structure of Micro-Channel for Stress and Blood or Drug Flow Optimization

In vivo photoacoustic assessment of the oxygen saturation changes in the human radial artery: a preliminary study associated with age

The functional indexes of RBCs and microcirculation in the traumatic brain injury with the action of 2-ethil-6-methil-3-hydroxypiridin succinate

Contact Info

Product

Resources

About