Erythrocyte membrane camouflaged graphene oxide for tumor-targeted photothermal-chemotherapy

Li, Jian; Huang, Xueyuan; Huang, Rong; Jiang, Jing; Wang, Yanjie; Zhang, Junhua; Jiang, Haiye; Xiang, Xinying; Chen, Wansong; Nie, Xinmin; Gui, Rong

doi:10.1016/j.carbon.2019.02.056

Cited by 36 publications

(27 citation statements)

References 47 publications

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“…Our results collectively indicated that CNSI had large absorption cross‐section, excellent photothermal conversion efficiency and low toxicity, making CNSI suitable for PTT of tumors. The PTT performance of CNSI was competitive to other carbon nanomaterials 10‐12,26,27 . Considering the two main issues hindering the clinical uses of carbon nanomaterials, CNSI had congenital advantages.…”

Section: Resultsmentioning

confidence: 99%

“…For examples, Lu et al modified carbon nanotubes (CNTs) with polyethylene glycol, Cy7, and insulin‐like growth factor receptor for optical imaging guided PTT of orthotopic pancreatic cancer 10 . Li et al prepared erythrocyte membrane camouflaged graphene oxide for photothermal chemotherapy, where the heat was able to promote the release of doxorubicin (DOX) and ablate the tumor 11 . Dong et al found that bamboo charcoal nanoparticles had good photothermal performance and could be used as NIR responsive drug carrier of DOX for the chemotherapy/photothermal dynergistic therapy 12 .…”

Section: Introductionmentioning

confidence: 99%

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Carbon nanoparticles suspension injection for photothermal therapy of xenografted human thyroid carcinoma in vivo

Huang

Zeng

Qian

et al. 2020

MedComm

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Due to the unique structure, carbon nanomaterials could convert near‐infrared (NIR) light into heat efficiently in tumor ablation using photothermal therapy (PTT). Carbon nanoparticles suspension injection (CNSI) is a commercial imaging reagent for lymph node mapping. CNSI has similar structural characteristics to other carbon nanomaterials, and thus, might be applied as photothermal agent. Herein, we evaluated the photothermal conversion ability and therapeutic effects of CNSI on thyroid carcinoma. CNSI was composed by carbon nanoparticle cores and polyvinylpyrrolidone K30 as the dispersion reagent. CNSI absorbed NIR light efficiently following the Lambert‐Beer law. The temperature of CNSI dispersion increased quickly under the NIR irradiation. CNSI killed the TCP‐1 thyroid carcinoma cells under 808 nm laser irradiation at 0.5 W/cm2, while CNSI or NIR irradiation treatment alone did not demonstrate this effect. Temperature increases were observed in tumor injected with CNSI under NIR irradiation. After three irradiation treatments, the tumor growth was completely blocked and the disruption of cellular structure was observed. When the tumor temperatures reached 53°C during treatment, the tumors did not recur within the observation period of 3 months. Our results suggested that CNSI might be used for PTT through “off label” use to benefit the patients immediately.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Carbon nanoparticles suspension injection for photothermal therapy of xenografted human thyroid carcinoma in vivo

Huang

Zeng

Qian

et al. 2020

MedComm

View full text Add to dashboard Cite

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“…In another study, graphene oxide NPs were prepared by incorporating ICG as photosensitizer along with DOX as the chemotherapeutic agent and the shell was made of RBC-membrane inserted with FA as targeting molecule. These NPs showed excellent biocompatibility and remarkable ability to evade the RES clearance [ 75 ]. Hybrid membranes of various kinds of cells could efficiently be coated onto the surface of NPs in order to achieve the desired functions [ 76 ].…”

Section: Applications Of Ners In Cancer Therapy and Diagnosismentioning

confidence: 99%

Chronicles of Nanoerythrosomes: An Erythrocyte-Based Biomimetic Smart Drug Delivery System as a Therapeutic and Diagnostic Tool in Cancer Therapy

et al. 2021

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Recently, drug delivery using natural biological carriers has emerged as one of the most widely investigated topics of research. Erythrocytes, or red blood cells, can act as potential carriers for a wide variety of drugs, including anticancer, antibacterial, antiviral, and anti-inflammatory, along with various proteins, peptides, enzymes, and other macromolecules. The red blood cell-based nanocarrier systems, also called nanoerythrosomes, are nanovesicles poised with extraordinary features such as long blood circulation times, the ability to escape immune system, the ability to release the drug gradually, the protection of drugs from various endogenous factors, targeted and specified delivery of drugs, as well as possessing both therapeutic and diagnostic applications in various fields of biomedical sciences. Their journey over the last two decades is escalating with fast pace, ranging from in vivo to preclinical and clinical studies by encapsulating a number of drugs into these carriers. Being biomimetic nanoparticles, they have enhanced the stability profile of drugs and their excellent site-specific targeting ability makes them potential carrier systems in the diagnosis and therapy of wide variety of tumors including gliomas, lung cancers, breast cancers, colon cancers, gastric cancers, and other solid tumors. This review focuses on the most recent advancements in the field of nanoerythrosomes, as an excellent and promising nanoplatform for the novel drug delivery of various drugs particularly antineoplastic drugs along with their potential as a promising diagnostic tool for the identification of different tumors.

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“…F-RGID had hydrodynamic size and zeta potential of approximately 170 nm and -28 mV, respectively. In vivo PTT study showed that F-RGID could increase the temperature in tumor area from around 32 °C to 48 °C after laser irradiation at 808 nm with intensity of 2 W/cm 2 for 300 s, which effectively reduced the tumor volume 91.…”

Section: Applications Of Erythrocyte-based Nanomedicinementioning

confidence: 99%

“…Owing to the significant advances in surface engineering of RBCm, now it is possible to not only functionalize RBCs and RBCm-cloaked nanoparticles for targeting cancer and imaging, but also to do at the same time theranostic nanomedicine with combined therapy to combat cancer. A number of studies have reported the combination of PDT/PTT with chemotherapy based on engineered RBCs and RBCm-cloaked nanoparticles 91-94. Furthermore, PTT can be combined with immunotherapy.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Advances in refunctionalization of erythrocyte-based nanomedicine for enhancing cancer-targeted drug delivery

et al. 2019

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Cancer remains a daunting and cureless disease, which is responsible for one-sixth of human deaths worldwide. These mortality rates have been expected to rise in the future due to the side effects of conventional treatments (chemotherapy, radiotherapy, and surgery), which can be addressed by applying nanomedicine. In order to escape from biological barriers, such nanomedicine should be mimicked and designed to be stealthy while navigating in the bloodstream. To achieve this, scientists take advantage of erythrocytes (red blood cells; RBCs) as drug carriers and develop RBC membrane (RBCm) coating nanotechnology. Thanks to the significant advances in nanoengineering, various facile surface functionalization methods can be applied to arm RBCm with not only targeting moieties, but also imaging agents, therapeutic agents, and nanoparticles, which are useful for theranostic nanomedicine. This review focuses on refunctionalization of erythrocyte-based nanomedicine for enhancing cancer-targeted drug delivery.

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Erythrocyte membrane camouflaged graphene oxide for tumor-targeted photothermal-chemotherapy

Cited by 36 publications

References 47 publications

Carbon nanoparticles suspension injection for photothermal therapy of xenografted human thyroid carcinoma in vivo

Carbon nanoparticles suspension injection for photothermal therapy of xenografted human thyroid carcinoma in vivo

Chronicles of Nanoerythrosomes: An Erythrocyte-Based Biomimetic Smart Drug Delivery System as a Therapeutic and Diagnostic Tool in Cancer Therapy

Advances in refunctionalization of erythrocyte-based nanomedicine for enhancing cancer-targeted drug delivery

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