Carbon nanoparticles suspension injection for photothermal therapy of xenografted human thyroid carcinoma in vivo

Abstract

Due to the unique structure, carbon nanomaterials could convert near‐infrared (NIR) light into heat efficiently in tumor ablation using photothermal therapy (PTT). Carbon nanoparticles suspension injection (CNSI) is a commercial imaging reagent for lymph node mapping. CNSI has similar structural characteristics to other carbon nanomaterials, and thus, might be applied as photothermal agent. Herein, we evaluated the photothermal conversion ability and therapeutic effects of CNSI on thyroid carcinoma. CNSI was composed by carbon nanoparticle cores and polyvinylpyrrolidone K30 as the dispersion reagent. CNSI absorbed NIR light efficiently following the Lambert‐Beer law. The temperature of CNSI dispersion increased quickly under the NIR irradiation. CNSI killed the TCP‐1 thyroid carcinoma cells under 808 nm laser irradiation at 0.5 W/cm2, while CNSI or NIR irradiation treatment alone did not demonstrate this effect. Temperature increases were observed in tumor injected with CNSI under NIR irradiation. After three irradiation treatments, the tumor growth was completely blocked and the disruption of cellular structure was observed. When the tumor temperatures reached 53°C during treatment, the tumors did not recur within the observation period of 3 months. Our results suggested that CNSI might be used for PTT through “off label” use to benefit the patients immediately.

Nanoparticles: Promising Auxiliary Agents for Diagnosis and Therapy of Thyroid Cancers

“…Carbon nanoparticles may also be used for this indication. When injected into thyroid cancer TPC-1 xenografts in mice, the particles absorbed NIR light, converting light into heat and achieving a temperature of 50-56 • C in the tumor, visualized by IR thermal imaging [63]. With this photothermal therapy, a temperature of 53 • C resulted in complete ablation of the tumor without overt systemic toxicity, as identified by body weight (as the only parameter provided).…”

Syntheses, characterization, and suppression efficiency of silver & silver iodide nanoparticle for proliferation, migration, and invasion in follicular thyroid carcinoma cells

“…The initial treatment of thyroid cancer was surgical and depended, for the most part, on the extent of the local condition. The nanomaterials have wide biomedical applications such as photothermal therapy [3], photodynamic therapy [4], a drug targeted delivery [5], genetic therapy [6], immunotherapy [7], etc.…”

NIR-II-activated biocompatible hollow nanocarbons for cancer photothermal therapy

“…Over the past few years, nanocarbon materials emerged as promising functional probes in biological areas due to their limited cytotoxicity, low fabrication cost, stable optical properties and versatile surface modification [ 19 , 20 ]. In addition, owing to their unique molecular structures, the sp 2 domains in nanocarbon materials can efficiently absorb NIR light and excite surface plasmons, followed by converting the transmitting random dipoles and resonance into thermal energy [ 21 ]. The strong absorption in NIR regions and lower energy requirement for photo induction endows great potential in PTTs.…”

“…The strong absorption in NIR regions and lower energy requirement for photo induction endows great potential in PTTs. Various nanocarbon materials, including nanocarbon suspensions [ 21 ], carbon nanotubes [ 22 ], graphene and graphene oxide [ 23 , 24 ], have been reported for photothermal tumor ablation. Despite the promising features of nanocarbon materials, two major issues severely hinder the further development of them in clinical.…”