NIR-II-activated biocompatible hollow nanocarbons for cancer photothermal therapy

Xu, Zhourui; Zhang, Yinling; Zhou, Wangxiao; Wang, Lijian; Xu, Gaixia; Ma, Mingze; Li, Fenghua; Wang, Zan; Wang, Yucheng; Kong, Tiantian; Zhao, Beibei; Wu, Weiping; Yang, Chengbin

doi:10.1186/s12951-021-00884-7

Cited by 33 publications

(20 citation statements)

References 43 publications

(32 reference statements)

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“…In addition, the extended biomedical application as drug carrier was also achieved utilizing the large internal cavity of HPP. All the results promised the HPP as a great potential in NIR-II laser-activated cancer photothermal therapy (Xu et al, 2021). Yang et al fabricated a novel nanocarrier composed of biodegradable charged polyester vectors (BCPVs) and graphene quantum dots (GQDs) for pancreatic cancer therapy applications.…”

Section: Other Materialsmentioning

confidence: 99%

Recent Progress on NIR-II Photothermal Therapy

Zhang

et al. 2021

Front. Chem.

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Photothermal therapy is a very promising treatment method in the field of cancer therapy. The photothermal nanomaterials in near-infrared region (NIR-I, 750-900 nm) attracts extensive attention in recent years because of the good biological penetration of NIR light. However, the penetration depth is still not enough for solid tumors due to high tissue scattering. The light in the second near-infrared region (NIR-II, 1000-1700 nm) allows deeper tissue penetration, higher upper limit of radiation and greater tissue tolerance than that in the NIR-I, and it shows greater application potential in photothermal conversion. This review summarizes the photothermal properties of Au nanomaterials, two-dimensional materials, metal oxide sulfides and polymers in the NIR-II and their application prospects in photothermal therapy. It will arouse the interest of scientists in the field of cancer treatment as well as nanomedicine.

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Section: Other Materialsmentioning

confidence: 99%

Recent Progress on NIR-II Photothermal Therapy

Zhang

et al. 2021

Front. Chem.

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“…In addition, MCNs have high efficiency in converting NIR laser energy into thermal energy and can be used in tumor PTT ( 72 , 149 ). Xu et al ( 45 ) designed polyethylene glycol-graft-polyethylenimine (HPP)-modified HCNs as NIR-II responsive PTAs. The experimental results showed that HPP-HCNs have a PCE of 45.1% under 1064nm laser irradiation.…”

Section: Classification Of Photothermal Nanomaterialsmentioning

confidence: 99%

Research Progress of Photothermal Nanomaterials in Multimodal Tumor Therapy

et al. 2022

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The aggressive growth of cancer cells brings extreme challenges to cancer therapy while triggering the exploration of the application of multimodal therapy methods. Multimodal tumor therapy based on photothermal nanomaterials is a new technology to realize tumor cell thermal ablation through near-infrared light irradiation with a specific wavelength, which has the advantages of high efficiency, less adverse reactions, and effective inhibition of tumor metastasis compared with traditional treatment methods such as surgical resection, chemotherapy, and radiotherapy. Photothermal nanomaterials have gained increasing interest due to their potential applications, remarkable properties, and advantages for tumor therapy. In this review, recent advances and the common applications of photothermal nanomaterials in multimodal tumor therapy are summarized, with a focus on the different types of photothermal nanomaterials and their application in multimodal tumor therapy. Moreover, the challenges and future applications have also been speculated.

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“…As a kind of external stimulation, ultrasound has the risk of causing tumor metastasis or tissue damage under high intensity . Moreover, due to the limited therapeutic effect and the multi-drug resistance of cancer cells, chemotherapy alone often cannot completely eliminate tumor tissues, leading to tumor metastasis or regeneration. − Therefore, there is a pressing demand for relatively safe stimuli-responsive NDDSs with minimal cross-reaction with other therapeutic protocols for synergistic cancer therapy.…”

Section: Introductionmentioning

confidence: 99%

All-In-One Second Near-Infrared Light-Responsive Drug Delivery System for Synergistic Chemo-Photothermal Therapy

Zhou

Xie

Zhou

et al. 2022

ACS Appl. Bio Mater.

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Light-responsive nanocarrier-based drug delivery systems (NDDSs), due to their unique advantages such as safety, minimal cross-reaction, and spatiotemporal precision, have received wide attention. Notably, second near-infrared (NIR-II) light, which has a high penetration depth for manipulating NDDSs to release drugs, is in high demand. Herein, polyethylene glycol (PEG)-modified hollow Cu x S nanoparticles (NPs) are developed as an all-in-one NIR-II light-responsive NDDS for synergistic chemo-photothermal therapy. First, Cu x S-PEG NPs were prepared under mild conditions by using Cu 2 O NPs as sacrificial templates. The morphology, photothermal effect, drug loading/releasing abilities, and synergistic chemo-photothermal therapy of Cu x S-PEG NPs have been investigated. The Cu x S-PEG NPs with hollow structures showed a high drug loading capacity (∼255 μg Dox per mg of Cu x S NPs) and stimuli-responsive drug release triggered by NIR-II laser irradiation. The synergistic chemo-photothermal therapy based on the Dox/Cu x S-PEG NPs showed 98.5% tumor elimination. Our study emphasizes the great potential of Cu x S-PEG NPs as an all-in-one NIR-II light-responsive NDDS for applications in biomedicine.

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NIR-II-activated biocompatible hollow nanocarbons for cancer photothermal therapy

Cited by 33 publications

References 43 publications

Recent Progress on NIR-II Photothermal Therapy

Recent Progress on NIR-II Photothermal Therapy

Research Progress of Photothermal Nanomaterials in Multimodal Tumor Therapy

All-In-One Second Near-Infrared Light-Responsive Drug Delivery System for Synergistic Chemo-Photothermal Therapy

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