Erythrocyte Life Span in Growing Swine as Determined by Glycine-2-C14

Abstract

Red blood cell survival studies were performed on five normal growing swine by following the C14-specific activity of hemoglobin and heme after the administration of glycine-2-C14. The erythrocytes of normal growing swine appear to be destroyed both by a random and an age-dependent process. Random destruction accounts for the larger portion of the cells which are destroyed. The "mean" red cell survival time was 62 days. This represents the interval from the time of incorporation of 50 per cent of the maximal amount of labelling achieved to the time when the level had decreased once more to the 50 per cent amount. The " ‘corrected’ average potential life span" of the red cells was 86 ± 11.5 days. This figure was obtained by subtracting the number of days required to attain 80 per cent of the maximal labelling from the average survival time of red cells destroyed by an age-dependent process as distinguished from random destruction.

Studies of red cell life span in the rat

“…Both the results of the 59Fe studies and the 51Cr studies presented above suggest that whereas the mean potential life span in the normal rat is relatively constant, the rate of random destruction may vary considerably from one individual to another. Similar conclusions were reached by Bush et at. (1955) and by Neuberger & Niven (1951) in their respective studies on swine and rabbits.…”

“…The finding of a significant degree of random destruction in the rat is of interest in view of the similar observations by Neuberger & Niven (1951) with 15N-labelled cells in rabbits, by with 59Fe-labelled cells in cats and rabbits and by Bush, Berlin, Jensen, Brill, Cartwright & Wintrobe (1955) with 59Fe-labelled cells in swine. On the other hand, no evidence of random destruction in the cat was found by Valentine, Pearce, Riley, Richter & Lawrence (1951).…”

Experimental production of siderocytes.

“…[17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35] (19)(20)(21)(22)(23)(24)(25)(26) * The values tabulated are the means of the last determinations before discontinuing phlebotomy or phenylhydrazine administration; the figures in parentheses refer to observed range. 3%7o or less within 4 days in both animals.…”

Lessons from sheep models of transfusion

“…Comparison of animals commonly used to model transfusion against humans. (Adapted from Simonova et al[19])[2,[13][14][15][16][18][19][20][21][22][23] …”