Erythrocyte Ferritin

Porter, F. Stanley

doi:10.1203/00006450-197312000-00003

Cited by 6 publications

(2 citation statements)

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“…Thus, importantly, ferritin is made in cells (including intestinal cells), and not in serum. We also note the evidence for the presence of ferritin within erythrocytes, [40][41][42][43][44][45][46][47][48][49][50][51][52][53][54] the largest volume fraction of serum. 55 In nucleated cells, ferritin resides mainly in the cytoplasm, but there are nuclear [56][57][58][59][60][61] and mitochondrial [62][63][64] forms (not considered here, as our focus is serum ferritin).…”

Section: A Systems Biology Overview Of Human Iron Metabolismmentioning

confidence: 83%

“…440,441 Correlation of platelet microparticles with serum ferritinfurther evidence for the cell damage hypothesis As mentioned, a considerable number of papers note the presence of ferritin in erythrocytes, the largest cellular compartment in blood. 40,[43][44][45][46][47][48][49][50]53,54 In RBCs, one of the more notable cell death mechanisms is eryptosis, a suicidal death of erythrocytes; this is characterized by erythrocyte shrinkage, blebbing, and phospholipid scrambling of the cell membrane. There is limited evidence that eryptosis occurs in iron overload conditions like b-thalassemia.…”

Section: Association Between Serum Ferritin and Biomarkers Of Liver D...mentioning

confidence: 99%

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Serum ferritin is an important inflammatory disease marker, as it is mainly a leakage product from damaged cells

2014

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"Serum ferritin" presents a paradox, as the iron storage protein ferritin is not synthesised in serum yet is to be found there. Serum ferritin is also a well known inflammatory marker, but it is unclear whether serum ferritin reflects or causes inflammation, or whether it is involved in an inflammatory cycle. We argue here that serum ferritin arises from damaged cells, and is thus a marker of cellular damage. The protein in serum ferritin is considered benign, but it has lost (i.e. dumped) most of its normal complement of iron which when unliganded is highly toxic. The facts that serum ferritin levels can correlate with both disease and with body iron stores are thus expected on simple chemical kinetic grounds. Serum ferritin levels also correlate with other phenotypic readouts such as erythrocyte morphology. Overall, this systems approach serves to explain a number of apparent paradoxes of serum ferritin, including (i) why it correlates with biomarkers of cell damage, (ii) why it correlates with biomarkers of hydroxyl radical formation (and oxidative stress) and (iii) therefore why it correlates with the presence and/or severity of numerous diseases. This leads to suggestions for how one might exploit the corollaries of the recognition that serum ferritin levels mainly represent a consequence of cell stress and damage.

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Section: A Systems Biology Overview Of Human Iron Metabolismmentioning

confidence: 83%

Section: Association Between Serum Ferritin and Biomarkers Of Liver D...mentioning

confidence: 99%

Serum ferritin is an important inflammatory disease marker, as it is mainly a leakage product from damaged cells

2014

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Assessment of Iron Status by Erythrocyte Ferritin in Uremic Patients With or Without Recombinant Human Erythropoietin Therapy

Caravaca

Vagace

Aparicio

et al. 1992

American Journal of Kidney Diseases

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