Erythrocyte Destruction under Periodically Fluctuating Shear Rate: Comparative Study with Constant Shear Rate

Hashimoto, Shigehiro

doi:10.1111/j.1525-1594.1989.tb01558.x

Cited by 40 publications

(21 citation statements)

References 17 publications

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“…Experiments with RBCs have shown that, below a certain level for

\bar{τ}

, no hemolysis is observed. In order to take into account this observation, a shear‐stress threshold

{\overset{τ}{true}}_{s}

below which hemolysis is inactive was introduced in later versions of Model A and of most further models.…”

Section: A‐the Power‐law Equation Modelmentioning

confidence: 99%

“…Numerical results are compared with experimental data presented in Ref. ( ). In the experiment, a heparinized sample (hematocrit 38%–45%) of canine blood is filled between a stationary convex circular cone, and a rotating concave circular cone (rheometer) .…”

Section: Comparisons and Tentative Validationsmentioning

confidence: 99%

“…( ). In the experiment, a heparinized sample (hematocrit 38%–45%) of canine blood is filled between a stationary convex circular cone, and a rotating concave circular cone (rheometer) . The rotor‐convex is driven to rotate with sinusoidal speed, thus generating a sinus‐oscillating shear rate in the blood.…”

Section: Comparisons and Tentative Validationsmentioning

confidence: 99%

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A Review of Hemolysis Prediction Models for Computational Fluid Dynamics

et al. 2017

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Flow-induced hemolysis is a crucial issue for many biomedical applications; in particular, it is an essential issue for the development of blood-transporting devices such as left ventricular assist devices, and other types of blood pumps. In order to estimate red blood cell (RBC) damage in blood flows, many models have been proposed in the past. Most models have been validated by their respective authors. However, the accuracy and the validity range of these models remains unclear. In this work, the most established hemolysis models compatible with computational fluid dynamics of full-scale devices are described and assessed by comparing two selected reference experiments: a simple rheometric flow and a more complex hemodialytic flow through a needle. The quantitative comparisons show very large deviations concerning hemolysis predictions, depending on the model and model parameter. In light of the current results, two simple power-law models deliver the best compromise between computational efficiency and obtained accuracy. Finally, hemolysis has been computed in an axial blood pump. The reconstructed geometry of a HeartMate II shows that hemolysis occurs mainly at the tip and leading edge of the rotor blades, as well as at the leading edge of the diffusor vanes.

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“…Experiments with RBCs have shown that, below a certain level for

\bar{τ}

, no hemolysis is observed. In order to take into account this observation, a shear‐stress threshold

{\overset{τ}{true}}_{s}

below which hemolysis is inactive was introduced in later versions of Model A and of most further models.…”

Section: A‐the Power‐law Equation Modelmentioning

confidence: 99%

Section: Comparisons and Tentative Validationsmentioning

confidence: 99%

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A Review of Hemolysis Prediction Models for Computational Fluid Dynamics

et al. 2017

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“…The latter generally occurs within 24 h after transfusion (Qian et al, 2001). In extracorporeal circulation, destruction of blood cells caused by factors such as continuous mechanical stress is a continuing problem that has attracted much attention (Blackshear and Forstrom, 1973;Nerem, 1981;Tillman et al, 1984;Wurzinger et al, 1986;Pohl et al, 1998;Steines et al, 1999;Affeld et al, 1998Affeld et al, , 1997Mizuguchi et al, 1994;Hashimoto, 1989) and it is necessary to prevent such erythrocyte damage or hemolysis. A number of studies rely on in vitro testing of blood hemolysis using animal blood in various simulated circulation environments (Kawahito and Nosé, 1997;Schima et al, 1993;Mathews and Sistino, 2001;Yasuda et al, 2001;Kawahito et al, 2001;Tamari et al, 1993).…”

Section: Introductionmentioning

confidence: 99%

Trauma to erythrocytes induced by long term in vitro pumping using a roller pump

Ding

Zhang³

et al. 2007

Cell Biology International

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The objective of this study is to investigate the impact of trauma on erythrocyte caused by long term in vitro pumping using roller pump. Ten bags of human blood (400 ml each) were provided by a local blood bank and they were divided into two groups with five bags in each group. Each blood bag was subject to pumping in a closed circuit, which was composed of silica gel tubes and a roller pump. Polystan and COBE pumps were used for the two groups, respectively. The blood was pumped for 16 h in vitro. Free hemoglobin (FHb), platelets (PLT), erythrocyte fragility (EF), and morphological analysis of erythrocytes observed under scanning electron microscope were measured to evaluate the impact of trauma on erythrocytes. A small amount of blood was collected for analysis before pumping, at the end of the 4th hour and then every 2 h till the end of the 16th hour. Some blood samples were also collected for electron microscope scanning before pumping and every 4 h during pumping. It was found that FHb and PLT linearly increased with the pumping time. There was a significant correlation between the two parameters (r=0.7745, p<0.001). The hemolysis indexes of the two groups were 0.296 and 0.3993 mg/L/h, respectively, with no significant difference. During the pumping process, EF changed slightly. The observation of scanning electron microscopy showed various deformed erythrocytes after pumping, including the distortion of cell membrane and the appearance of echinocytes, which increased with pumping time. This study demonstrated that long term pumping using roller pump not only caused the immediate rupture of red blood cells, i.e. the immediate hemolysis, but also caused sub-trauma to a large number of erythrocytes, which led to the delayed hemolysis. The change of erythrocyte morphology was the basis of the delayed hemolysis.

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“…Fig. 3.1 shows the cone/plate device [Shigehiro 1989] used to shear red blood cells. The cone/plate device was widely used in hemolysis analysis because there exists an approximated solution of uniformly distributed shear stress and that makes it easy to estimate the shear stresses experienced by the red cells.…”

Section: Mechanism Of Hemolysismentioning

confidence: 99%

Analysis and experiments on flow-induced hemolysis.

Chen¹

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Erythrocyte Destruction under Periodically Fluctuating Shear Rate: Comparative Study with Constant Shear Rate

Cited by 40 publications

References 17 publications

A Review of Hemolysis Prediction Models for Computational Fluid Dynamics

A Review of Hemolysis Prediction Models for Computational Fluid Dynamics

Trauma to erythrocytes induced by long term in vitro pumping using a roller pump

Analysis and experiments on flow-induced hemolysis.

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