Erythrocyte autoantibodies, autoimmune haemolysis, and carcinoma.

Canine idiopathic immune-mediated haemolytic anaemia: a review with recommendations for future research

“…Most of these risk factors have been taken from the human literature (Sokol et al 1992(Sokol et al , 1994, and relatively few have been confirmed in dogs. Sulphonamides, cephalosporin, and carprofen have been linked with IMHA (Bloom et al 1988;Trepanier et al 2003;Trepanier 2004;Mellor et al 2005;Lavergne et al 2006).…”

Pleural Solitary Fibrous Tumor Complicated with Autoimmune Hemolytic Anemia

“…There is accumulating evidence that suggests that the neoplastic cells of at least some patients with these hematologic malignancies can produce RBC-specific autoantibodies (6,11). AIHA also occurs in patients with various non-hematologic tumors, including breast, lung, digestive tract, and prostate carcinomas; hypernephroma; and seminoma (7,(12)(13)(14)(15)(16)(17). However, the etiology of AIHA associated with non-hematologic malignancies still remains poorly understood (14,15).…”

“…AIHA also occurs in patients with various non-hematologic tumors, including breast, lung, digestive tract, and prostate carcinomas; hypernephroma; and seminoma (7,(12)(13)(14)(15)(16)(17). However, the etiology of AIHA associated with non-hematologic malignancies still remains poorly understood (14,15). Regarding tumors in the lung or pleural area, it has been reported that serum immunoglobulin levels with IgG and IgA predominances are significantly elevated in patients with lung carcinoma and that a benign bronchial cyst synthesized IgG antibodies directed against the patient's own RBCs (18)(19)(20).…”

“…On the other hand, Kopczy!ski et al reported that RBC membranes in patients with ovarian cancer are prone to hemolysis (22). Another possibility, which has been suggested in various tumors, is that the antibodies against the tumor surface antigens have cross-reactivity with RBCs (14,(18)(19)(20)(21)(22).…”

“…Therefore, it is unlikely that abnormal RBC membranes resulted in hemolysis. We thus considered two possibilities; the first is that antibodies directed against RBCs were generated by the tumor (14,23,24); the second is that IgG antibodies directed against the antigens on the benign SFT may have combined with the patient's own RBCs, and it remains to be determined which mechanism caused AIHA in the present case. Notably, the initial treatment with a considerable dose of PSL did not have a sufficient effect on AIHA, whereas surgical resection of the SFT resulted in significant improvement of the patient's AIHA, which allowed us to rapidly taper the dose of PSL.…”