Erythrocyte antioxidant enzymes and selenium serum levels in an andean population

Agostoni, A; Gerli, Giancarla; Beretta, L.; Palazzini, Gabriele; Buso, G. P.; Xusheng, Hu; Moschini, G.

doi:10.1016/0009-8981(83)90400-x

Cited by 19 publications

(8 citation statements)

References 10 publications

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“…The low levels of GSH-Px activity and of SSe in the Peruvian Andean people have been attributed to the lower level of Se intake (21) however dietary Se intake has not been investigated at all. The reported level of SSe in their study (21) was almost 60% of that found in the high-altitude subjects of the present report (95.0 ng/ml); i.e., 59.0 ng/ml on the average, which is comparable with the values reported in Se-deficient countries (29) such as New Zealand or Finland (Table 4) . This discrepancy of SSe level between the report of Agostoni et al, and our study may be due to differences in dietary Se intake.…”

Section: Discussionsupporting

confidence: 81%

“…Hence, people living in the Andes at high altitudes are thought to have high GSH-Px activity, and consequently , the demand for Se is considered to be high compared to people living at sea level . Contrary to this assumed high demand for Se and GSH-Px , Agostoni et al (21) reported that SSe levels and GSH-Px activity in erythrocytes were low among people living in the Andes at high altitudes. This is virtually the only study which has examined SSe and GSH-Px in Peruvian natives at high and low altitudes .…”

Section: Discussionmentioning

confidence: 99%

“…For the Peruvian Andean people living at 3,800m above sea level, Agostoni et al (21) reported that the SSe concentration and GSH-Px activity in erythrocytes were markedly lower when compared to people of the same ethnic group living at sea level. The low levels of GSH-Px activity and of SSe in the Peruvian Andean people have been attributed to the lower level of Se intake (21) however dietary Se intake has not been investigated at all.…”

Section: Discussionmentioning

confidence: 99%

“…This observation is in agreement with that of Agostoni et al . (21). (They also expressed the GSH-Px activity in Units/g Hb.…”

Section: Discussionmentioning

confidence: 99%

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Selenium Levels and Glutathione Peroxidase Activities in Blood in an Andean High-Altitude Population.

Imai

Kashiwazaki

Suzuki

et al. 1995

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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SummarySelenium (Se) levels in blood (whole blood, erythrocytes and serum) and blood glutathione peroxidase (GSH-Px) activity were investigated in people living at high altitude in Bolivia (4,000 m above sea level). These parameters were compared to those of people living at low altitude (300 m above sea level). The Se levels in whole blood of the high-altitude subjects did not differ significantly from those of the low altitude subjects. However, the Se levels in erythrocytes were significantly lower in the high-altitude subjects than in the low-altitude subjects, whereas serum Se levels were higher in the high-altitude subjects than in the low-altitude subjects. GSH-Px activity (Unit/g Hb) was significantly lower in the high-altitude subjects than in the low-altitude subjects. The mean corpuscular Hb concentration (MCHC), an indicator of the age of erythrocytes, in the high-altitude subjects was significantly higher than in the low-altitude subjects. These results show that the GSH-Px activity in the blood of the high-altitude subjects is relatively low. This may be due to their aged erythrocytes and/or to relatively low Se intake in the

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Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…This observation is in agreement with that of Agostoni et al . (21). (They also expressed the GSH-Px activity in Units/g Hb.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Selenium Levels and Glutathione Peroxidase Activities in Blood in an Andean High-Altitude Population.

Imai

Kashiwazaki

Suzuki

et al. 1995

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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“…Membranes are protected against oxygen free radical damage by glutathione peroxidase, which uses selenium as a coenzyme. Selenium deficiency is common in Finland 13 and amongst the Andeans 14 . Finnish women with cholestasis of pregnancy have lower levels of selenium and glutathione peroxidase than unaffected controls 13 .…”

Section: Aetiologymentioning

confidence: 99%

Cholestasis of pregnancy

McDonald¹

1999

J of Gastro and Hepatol

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Cholestasis of pregnancy is the commonest liver disease unique to pregnancy and is characterized by pruritus in the mother in late pregnancy, without any skin rashes. This is accompanied by an elevation of the serum bile acids. Liver function test abnormalities may occur. Abdominal pain is not a feature and liver failure does not occur. The diagnosis is made by a suggestive history and exclusion of other causes by the history, serology and an upper abdominal ultrasound. All symptoms and signs should disappear within 4 weeks post-partum; prolonged post-partum courses should prompt a search for other causes, such as primary biliary cirrhosis. The syndrome is associated with a five-fold increased incidence of stillbirth, intra-partum foetal distress and pre-term labour. The reason is not clear and not predictable. The accepted management is induction or delivery at 38 weeks, which has led to a reduction in poor foetal outcome. Preliminary studies using ursodeoxycholic acid show symptomatic and biochemical improvement in most women treated. There is also a suggestion of an improved foetal outcome and treatment should be considered in women who present with the condition earlier in pregnancy.

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Trace elements in environmental and health sciences

Iyengar¹,

Iyengar

1994

Determination of Trace Elements

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Erythrocyte antioxidant enzymes and selenium serum levels in an andean population

Cited by 19 publications

References 10 publications

Selenium Levels and Glutathione Peroxidase Activities in Blood in an Andean High-Altitude Population.

Selenium Levels and Glutathione Peroxidase Activities in Blood in an Andean High-Altitude Population.

Cholestasis of pregnancy

Trace elements in environmental and health sciences

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