Selenium Levels and Glutathione Peroxidase Activities in Blood in an Andean High-Altitude Population.

Imai, Hideki; Kashiwazaki, Hiroshi; Suzuki, Tsuguyoshi; Kabuto, Michinori; Himeno, Seiichiro; Watanabe, Chiho; Moji, Kazuhiko; Sw, Kim; Jo, Rivera; Takemoto, Tai‐ichiro

doi:10.3177/jnsv.41.349

Cited by 34 publications

(16 citation statements)

References 33 publications

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“…A reduction in the activity of superoxide dismutase (SOD) content in skeletal muscle has been reported in rats exposed to intermittent hypobaric hypoxia (Radak et al, 1994). Reduction in the activity of glutathione peroxidase (GPX) has also been shown in the liver of rats exposed to high altitude (Nakanishi et al, 1995), whereas Imai et al (1995) compared GPX activity of high altitude residents (4,000 m) to individuals from sea level, fi nding that high-altitude dwellers had lower levels of GPX activity. Nevertheless, it has been observed that catalase (CAT), SOD and also the heat shock proteins lead to the stabilization of cell membranes and restriction of apoptosis, alleviating the oxidative eff ect when subjected to hypobaric hypoxia (Manukhina et al, 2006).…”

Section: Oxidative Stressmentioning

confidence: 99%

Acclimatization to chronic intermittent hypoxia in mine workers: a challenge to mountain medicine in Chile

Farías

Jiménez²,

Osorio³

et al. 2013

Biol. Res.

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In the past two decades, Chile has developed intense mining activity in the Andes mountain range, whose altitude is over 4,000 meters above sea level. It is estimated that a workforce population of over 55,000 is exposed to high altitude hypobaric hypoxia. The miners work under shift systems which vary from 4 to 20 days at the worksite followed by rest days at sea level, in a cycle repeated for several years. This Chronic Intermittent Hypoxia (CIH) constitutes an unusual condition for workers involving a series of changes at the physiological, cellular and molecular levels attempting to compensate for the decrease in the environmental partial pressure of oxygen (PO 2 ). The mine worker must become acclimatized to CIH, and consequently undergoes an acute acclimatization process when he reaches the worksite and an acute reverse process when he reaches sea level. We have observed that after a period of 3 to 8 years of CIH exposure workers acclimatize well, and evidence from our studies and those of others indicates that CIH induces acute and chronic multisystem adjustments which are eff ective in off setting the reduced availability of oxygen at high altitudes. The aims of this review are to summarize fi ndings of the physiological responses to CIH exposure, highlighting outstanding issues in the fi eld.

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Section: Oxidative Stressmentioning

confidence: 99%

Acclimatization to chronic intermittent hypoxia in mine workers: a challenge to mountain medicine in Chile

Farías

Jiménez²,

Osorio³

et al. 2013

Biol. Res.

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“…As reported in several epidemiological studies carried out in people with specific life habits or in residents of particular geographic areas, age, gender, medical condition or treatment, and living style are some aspects that determine antioxidant status in human (2,6).…”

Section: Introductionmentioning

confidence: 99%

Comparison of Whole-Blood Glutathione Peroxidase Activity, Levels of Serum Selenium, and Lipid Peroxidation in Subjects from the Fishing and Rural Communities of "Rabo de Peixe" Village, San Miguel Island, The Azores' Archipelago, Portugal

Pavão

Cordeiro

Costa

et al. 2003

BTER

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The activity of glutathione peroxidase (GSH-Px), serum selenium (Se), and thiobarbituric acid reactive substances (TBARS) were measured in the whole blood of 148 healthy adults aged 20-60 yr from the fishing and rural communities of "Rabo de Peixe," The Azores, Portugal.The subjects did not live in the same household and had different socioeconomic profiles and dietary habits. The serum lipid profile and selected life habits were also considered in this study. No significant differences in the activity of GSH-Px were found in the interpopulation or intrapopulation analyses, classified by age or lipid profile. Biological Trace Element Research 27Vol. 92, 2003 ©Copyright 2003 by Humana Press Inc. All rights of any nature, whatsoever, reserved. 0163-4984/03/9201-0027 $20.00*Author to whom all correspondence and reprint requests should be addressed.An age-dependent GSH-Px increase was noted in the younger male (M) subgroups (20-39 yr). The Se levels were higher in fishers (f) of both genders (M, F) than in subjects living in the rural (r) environment: 110±25 µg/L (f, M), 89±20 µg/L (f, F), 88±22 µg/L (r, M) and 80±17 µg/L (r, F). In the fishers, but not in the rural population, Se was higher in the males, but it did not show significant variation with age. The levels of TBARS were lower in the f than in the r male group. The Se level was lower and TBARS higher in the hyperlipemic women in the f group, compared to the corresponding controls.Our results suggest that the fishers (mainly men) show a better antioxidant status than that of their rural counterparts, due to differences in dietary habits between the study populations and between genders.

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“…We did not find any information in literature on GPxA and lipid peroxidation evaluated in the plasma, lungs, heart, and liver of broilers fed GSE and raised at high altitude. However, Imai et al (1995) found that people residing at high altitude (4000 m) had low levels of glutathione peroxidase activity in the serum. El-Damrawy (2014) reported a decrease in MDA concentration and an increase in glutathione concentration and superoxide dismutase activity in the liver of broilers fed 100 or 200 mg of GSE kg -1 of diet and raised under heat stress conditions at low altitude (11 m, approximately).…”

Section: Discussionmentioning

confidence: 99%

Lipid Peroxidation in the Plasma, Lungs, Heart and Liver of Broilers Fed a Grape Seed Extract and Raised at 2278 m of Altitude

Rodríguez-Ortega

Juárez-Juárez

Pró-Martínez

et al. 2017

Rev. Bras. Cienc. Avic.

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Grape seed extract, high altitude, lipid peroxidation, vitamin E. ABSTRACTThe aim of this research was to evaluate the effect of partial substitution of vitamin E (VE) by grape seed extract (GSE) on glutathione peroxidase activity (GPxA), nitric oxide (NO) concentration and lipid peroxidation [malondialdehyde (MDA) concentration] in the plasma, lungs, heart and liver, and live performance of broilers raised at 2278 m of altitude. One-d-old Ross 308 male chickens (n = 420) were randomly distributed into three treatments: Control-AL (basal diet containing 40 IU of VE and fed ad libitum; AL), Control-FR (basal diet and feed restriction; FR) and GSE-AL [basal diet containing 10 mg of GSE (equivalent to 30 IU VE) plus 10 IU of VE and fed AL]. The data were analyzed using one-way analysis of variance. Glutathione peroxidase activity, and NO and MDA concentrations in the plasma were evaluated on d 46. On d 47, MDA was evaluated in the lungs, heart and liver. Live performance parameters were recorded weekly. There were no significant differences (p>0.05) in live performance and NO concentration among treatments. Birds from the GSE-AL treatment presented the lowest (p<0.05) GPxA, the highest (p<0.05) MDA concentration in the plasma, heart and liver, and intermediate MDA concentration in the lungs. Our results suggest that GSE may partially replace VE in broiler diets without impairment of live performance. However, further research is required to determine the optimal level of dietary GSE inclusion to reduce lipid peroxidation in the plasma, lungs, heart, and liver of broilers raised at 2278 m of altitude.

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Selenium Levels and Glutathione Peroxidase Activities in Blood in an Andean High-Altitude Population.

Cited by 34 publications

References 33 publications

Acclimatization to chronic intermittent hypoxia in mine workers: a challenge to mountain medicine in Chile

Acclimatization to chronic intermittent hypoxia in mine workers: a challenge to mountain medicine in Chile

Comparison of Whole-Blood Glutathione Peroxidase Activity, Levels of Serum Selenium, and Lipid Peroxidation in Subjects from the Fishing and Rural Communities of "Rabo de Peixe" Village, San Miguel Island, The Azores' Archipelago, Portugal

Lipid Peroxidation in the Plasma, Lungs, Heart and Liver of Broilers Fed a Grape Seed Extract and Raised at 2278 m of Altitude

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