Erythrocyte antioxidant enzyme activities in coal miners from three French regions

Nadif, Rachel; Porcher, Jean‐Marc; Dusch, Martine; Mur, J. M.; Auburtin, Guy

doi:10.1007/s004200050278

Cited by 8 publications

(5 citation statements)

References 23 publications

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“…Some researchers treated subjects exposed to underground coal dust with antioxidants (vitamin E 800 mg/day and vitamin C 500 mg/day) and found that oxidative stress biomarkers (contents of lipoperoxidation, protein carbonyls, αtocopherol, GSH, GSH-Px, SOD, CAT, and GST) were restored to pre-exposure values after antioxidant supplementation (64). Contrary to the above findings, a study on surface coal workers, underground coal workers without pneumoconiosis, and underground coal workers with simple pneumoconiosis showed no significant difference in antioxidant enzyme activities (SOD, CAT, and GSH-Px) between surface workers and underground workers without pneumoconiosis, no significant difference in Cu 2+ /Zn 2+ SOD activities between underground workers with simple pneumoconiosis and underground workers without pneumoconiosis (74).…”

Section: Underground Mining and Oxidative Stressmentioning

confidence: 55%

Oxidative Stress From Exposure to the Underground Space Environment

Gao

Zhou

2020

Front. Public Health

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There are a growing number of people entering underground spaces. However, underground spaces have unique environmental characteristics, and little is known about their effects on human health. It is crucial to elucidate the effects of the underground space environment on the health of humans and other organisms. This paper reviews the effects of hypoxia, toxic atmospheric particles, and low background radiation in the underground space environment on living organisms from the perspective of oxidative stress. Most studies have revealed that living organisms maintained in underground space environments exhibit obvious oxidative stress, which manifests as changes in oxidants, antioxidant enzyme activity, genetic damage, and even disease status. However, there are few relevant studies, and the pathophysiological mechanisms have not been fully elucidated. There remains an urgent need to focus on the biological effects of other underground environmental factors on humans and other organisms as well as the underlying mechanisms. In addition, based on biological research, exploring means to protect humans and living organisms in underground environments is also essential.

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Section: Underground Mining and Oxidative Stressmentioning

confidence: 55%

Oxidative Stress From Exposure to the Underground Space Environment

Gao

Zhou

2020

Front. Public Health

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“…More recently, in another study, we found no diVerences in catalase and Cu ++ /Zn ++ SOD activities between underground miners and surface workers in three diVerent mines. 35 As our studies are the only ones that have investigated the relations between occupational exposure and blood antioxidant enzyme activi-ties, the available information is perhaps too incomplete to explain these apparently contradictory results.…”

Section: Discussionmentioning

confidence: 92%

Relations between occupational exposure to coal mine dusts, erythrocyte catalase and Cu++/Zn++ superoxide dismutase activities, and the severity of coal workers' pneumoconiosis.

et al. 1998

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Objectives-To better understand the relations between occupational exposure, blood antioxidant enzyme activities, total plasma antioxidant concentration, and the severity of coal workers' pneumoconiosis (CWP). Methods-Blood samples were obtained from miners without CWP exposed to low dust concentrations for >4 years at the time of the study (n = 105), or exposed to high dust concentrations for >14 years at the time of the study (n=58), and from retired miners with CWP (n=19). Miners without CWP were classified into three subgroups according to their estimated cumulative exposure to dust. Chest x ray films were obtained for each miner. Miners were classified in five subgroups according to their International Labour Organisation (ILO) profusion grades. Univariate tests were completed by multiple linear regression analyses. Results-The estimated cumulative exposure to dust was strongly positively related to erythrocyte catalase activity and strongly negatively related to Cu ++ /Zn ++ SOD activity only in miners exposed to high dust concentrations for >14 years at the time of the study (F tests p=0.006 and p=0.004 respectively). Moreover, catalase activity was strongly related to the severity of CWP expressed as five subgroups of ILO profusion grades (F test p=0.003); the greatest diVerence in the mean values was found between the group of 1/1 to 1/2 ILO profusion grades and the group of 2/1 to 3/3 ILO profusion grades. Conclusion-These results are in good agreement with the hypothesis that production of reactive oxygen species may be an important event in the exposure to coal mine dusts and the severity of CWP. Erythrocyte catalase and Cu ++ /Zn ++ SOD activities are more closely related to recent exposure to high dust concentrations than to cumulative exposure, and could be considered as biological markers of exposure rather than as markers of early adverse biological eVect. (Occup Environ Med 1998;55:533-540)

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“…27 The elevated antioxidant enzyme levels found in different body fluids of patients with CWP were considered to reflect excessive ROS formation during coal dust exposure. [28][29][30][31][32] Elevated BAL antioxidant enzymes levels were also observed in coal miners. 5,28 In the present study, a significant increase was found only in serum SOD levels of patients with CWP.…”

Section: Discussionmentioning

confidence: 97%

Serum and BAL cytokine and antioxidant enzyme levels at different stages of pneumoconiosis in coal workers

et al. 2008

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Coal workers’ pneumoconiosis (CWP) is an occupational pulmonary disease that occurs by chronic inhalation of coal dust. CWP is divided into two stages depending on the extent of the disease, as simple pneumoconiosis (SP) and progressive massive fibrosis (PMF). In the present study, serum and bronchoalveolar lavage (BAL) cytokine (interleukin-1β [IL-1β], IL-6, tumor necrosis factor-α [TNF-α], transforming growth factor-β [TGF-β]) and antioxidant enzymes levels, their relation with the disease severity, and whether they can be considered as biological markers were investigated. Serum and BAL levels of IL-1β, IL-6, and TNF-α were higher in SP and PMF patient groups compared with that in active and retired miner groups. Serum and BAL IL-1β, IL-6, and TNF-α levels were also found to be higher in patients with PMF compared with the SP group. BAL superoxide dismutase (SOD), glutathione peroxidase, and catalase levels and serum SOD level were increased in both patient groups compared with the control group. In addition, mean serum and BAL TGF-β levels were found to be increased in patients with SP compared with PMF group. Based on these results, BAL and serum cytokine and antioxidant enzymes levels were evaluated and discussed as potential biomarkers for different stages of CWP.

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Erythrocyte antioxidant enzyme activities in coal miners from three French regions

Cited by 8 publications

References 23 publications

Oxidative Stress From Exposure to the Underground Space Environment

Oxidative Stress From Exposure to the Underground Space Environment

Relations between occupational exposure to coal mine dusts, erythrocyte catalase and Cu++/Zn++ superoxide dismutase activities, and the severity of coal workers' pneumoconiosis.

Serum and BAL cytokine and antioxidant enzyme levels at different stages of pneumoconiosis in coal workers

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