Erythroblastic transformation of chronic granulocytic leukemia: A clinical and cytogenetic case study

O'Malley, F. M.; Garson, O. Margaret; McGrath, K.M.; Elliott, Peter J.; Whiteside, M. G.

doi:10.1002/ajh.2830140408

Cited by 9 publications

(2 citation statements)

References 11 publications

(9 reference statements)

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“…In the case of erythroid blast cells, it has allowed their precise identification, by discovering the existence of ferritin particles as free molecules in the cytoplasm, forming aggregates, or surrounded by cytoplasmic membrane, which are associated with the absorption of the molecules of ferritin (rpheocytosis) and are characteristic of erythroblasts, even in their earliest forms. (14) These cells are highly undifferentiated, without heterochromatin; abundant ribosomes, endothelial reticulum and mitochondria are discovered in its cytoplasm; there is a very active Golgi complex and lipid vacuoles and glycogen aggregates are sometimes very apparent. (3,4,14) One of the great advances is the possibility of defining the…”

Section: Discussionmentioning

confidence: 99%

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Leukemia in Erythroid Blast Crisis and Autoimmune Hemolytic Anemia: A Case Report

Sierra1

Padrón²,

3³

et al. 2022

ijmras

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Introduction: Chronic myeloid leukemia is a chronic myeloproliferative neoplasm characterized by the uncontrolled proliferation of myeloid precursors and autoimmune hemolytic anemia is an unregulated immune reaction towards the antigens themselves that are on the surface of the membrane of red blood cells. The combination of these diseases is extremely rare and even greater when chronic myeloid leukemia is in an erythroid blast crisis. Objective: To describe a case with the coexistence of chronic myeloid leukemia in erythroid blast crisis and autoimmune hemolytic anemia. Clinical case: Patient with a history of chronic myeloid leukemia who presents an erythroid blast crisis and develops autoimmune hemolytic anemia due to warm IgG antibodies. The treatment for both diseases will be administered. After a clinical improvement of the autoimmune hemolytic anemia, he maintained the erythroid blast crisis and was administered an intensive chemotherapy regimen where complications occurred and he died. Conclusions: The treatment with steroids in autoimmune hemolytic anemia in patients with chronic myeloid leukemia is effective when they are in the chronic phase of the disease, but is little responsive when they are in blast crisis, as was the case we present, and the fatal outcome in the patient was multifactorial.

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Section: Discussionmentioning

confidence: 99%

“…(14) These cells are highly undifferentiated, without heterochromatin; abundant ribosomes, endothelial reticulum and mitochondria are discovered in its cytoplasm; there is a very active Golgi complex and lipid vacuoles and glycogen aggregates are sometimes very apparent. (3,4,14) One of the great advances is the possibility of defining the…”

Section: Discussionmentioning

confidence: 99%

Leukemia in Erythroid Blast Crisis and Autoimmune Hemolytic Anemia: A Case Report

Sierra1

Padrón²,

3³

et al. 2022

ijmras

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Chronic granulocytic leukemia: Correlation of elastic transformation type with karyotypic evolution

1985

American J Hematol

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Over a 3-year period, 26 patients with Philadelphia chromosome-positive chronic granulocytic leukemia were studied cytogenetically in both the chronic and blastic transformation phases of the disease; a further three patients were studied only after blastic transformation. Sixteen were considered to have adequate evidence of the type of transformation and form the basis of the report, where chromosome changes have been correlated with the morphological type of blastic transformation. Seven patients developed a myeloblastic transformation, seven a lymphoblastic transformation, and two an erythroblastic transformation. All patients in the myeloid group acquired one or more of the nonrandom changes associated with CGL blastic transformation, viz. +8,i(17q), +19, +22q-. Patients in the lymphoblastic group acquired structural abnormalities, apparently random in nature and usually in a small percentage of cells. The two patients with erythroblastic transformation developed markedly hyperdiploid cells (greater than 50 chromosomes) with both numerical and structural abnormalities. Patients in the lymphoblastic group appeared to have a slightly better prognosis than the myeloid group, whilst the patients with erythroblastic transformation had a very poor prognosis.

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Translocation (1;17) in accelerating and blast phases of chronic myelogeneous leukemia

Kerman¹,

Miller²

1986

Cancer Genetics and Cytogenetics

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Erythroblastic transformation of chronic granulocytic leukemia: A clinical and cytogenetic case study

Cited by 9 publications

References 11 publications

Leukemia in Erythroid Blast Crisis and Autoimmune Hemolytic Anemia: A Case Report

Leukemia in Erythroid Blast Crisis and Autoimmune Hemolytic Anemia: A Case Report

Chronic granulocytic leukemia: Correlation of elastic transformation type with karyotypic evolution

Translocation (1;17) in accelerating and blast phases of chronic myelogeneous leukemia

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