Erythematous Nodules in a Patient Infected With the Human Immunodeficiency Virus

Soni, Bhavik P.; Williford, Phillip M.; White, Wain L.

doi:10.1001/archderm.134.2.231-b

Cited by 13 publications

(7 citation statements)

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“…27 Five months after dapsone treatment these values returned to normal with an associated clinical improvement. 27…”

Section: Dermatopathology and Pathogenesismentioning

confidence: 91%

“…Prior to treatments they observed an increase in random migration of neutrophils that was directed towards IL‐8 (by 424%). There was a decreased selectivity towards the bacterial peptide analogue formyl‐methionyl‐leucyl‐phenylalanine by 98% suggesting that bacterial peptides and immune complexes may sustain the ongoing local inflammatory infiltrate and LCV . Five months after dapsone treatment these values returned to normal with an associated clinical improvement …”

Section: Dermatopathology and Pathogenesismentioning

confidence: 99%

See 1 more Smart Citation

Erythema elevatum diutinum: a review of presentation and treatment

Momen

Jorizzo

Al‐Niaimi

2014

Acad Dermatol Venereol

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Erythema elevatum diutinum (EED) is a rare, chronic and treatable skin condition. It has many histological mimics and is often associated with a variety of underlying systemic diseases, when these are present the management and prognosis dictates the course of the EED. This review aims to highlight the differential diagnosis, clinical manifestations of EED and the possible underlying systemic disease. It is important for clinicians to be aware that EED may predate underlying conditions and the presence of lesions may indicate underlying disease activity. In some cases one may need 'search' for underlying disease. Treatment of these lesions is notoriously difficult. Dapsone is used as the mainstay of treatment, however other options exist. We have highlighted different treatment options and suggested a treatment algorithm. In some cases, treatment may need to be targeted at underlying disease.

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“…27 Five months after dapsone treatment these values returned to normal with an associated clinical improvement. 27…”

Section: Dermatopathology and Pathogenesismentioning

confidence: 91%

Section: Dermatopathology and Pathogenesismentioning

confidence: 99%

Erythema elevatum diutinum: a review of presentation and treatment

Momen

Jorizzo

Al‐Niaimi

2014

Acad Dermatol Venereol

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“…[13][14][15] There have also been reports of associations with rheumatic arthritis, 3,16,17 prostate carcinoma, 3,18 testicular lymphoma, 3 celiac disease, 19 Crohn's disease, 20 relapsing polychondritis 21 and, more recently, with HIV infection. [22][23][24][25] Among young males, exacerbated clinical states with nodular lesions seem to be correlated with HIV infection, in contrast with the clinical picture observed for the general population. 24,25 The EED skin lesions of this patient allowed the detection of HIV infection through laboratory investigation.…”

Section: Discussionmentioning

confidence: 88%

“…[22][23][24][25] Among young males, exacerbated clinical states with nodular lesions seem to be correlated with HIV infection, in contrast with the clinical picture observed for the general population. 24,25 The EED skin lesions of this patient allowed the detection of HIV infection through laboratory investigation. There was no history of streptococcal infection, hematological disorders or autoimmune disease.…”

Section: Discussionmentioning

confidence: 88%

Erythema elevatum diutinum as a first clinical manifestation for diagnosing HIV infection: case history

et al. 2005

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CONTEXT: Erythema elevatum diutinum is a chronic and rare dermatosis that is considered to be a variant of leukocytoclastic vasculitis. It is probably mediated by immune complexes. It is generally associated with autoimmune, neoplastic and infectious processes. Recently, it has been added to the group of specific dermatoses that are associated with HIV. CASE REPORT: We report on the case of a patient who had erythema elevatum diutinum as the first clinical evidence for diagnosing HIV infection. Dapsone was used in the treatment of this patient, and partial regression of the lesions was achieved within 15 days, even before antiretroviral therapy was prescribed. CONCLUSION: When there is a diagnosis of erythema elevatum diutinum, HIV infection should be investigated, especially in atypical and exacerbated clinical manifestations.

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“…There has been a disproportionate number of HIVϩ patients reported in the literature suggesting a possible predisposition associated with HIV disease [34][35][36][37][38][39][40][41][42]. Compromised cellular immunity is likely a component of this illness as most patients have advanced HIV disease with absolute CD4 counts less than 200 cells/ml.…”

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confidence: 99%

Vasculitic Syndromes in HIV-Infected Patients

Bárbaro

2003

HIV Infection and the Cardiovascular System

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Erythematous Nodules in a Patient Infected With the Human Immunodeficiency Virus

Cited by 13 publications

References 0 publications

Erythema elevatum diutinum: a review of presentation and treatment

Erythema elevatum diutinum: a review of presentation and treatment

Erythema elevatum diutinum as a first clinical manifestation for diagnosing HIV infection: case history

Vasculitic Syndromes in HIV-Infected Patients

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