Vasculitic Syndromes in HIV-Infected Patients

Bárbaro, Giuseppe

doi:10.1159/000073183

Cited by 9 publications

(10 citation statements)

References 58 publications

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“…Kawasaki-like syndrome1617 and Takayasu's arteritis18 have also been described. Some HIV-infected patients have a clinical presentation resembling systemic lupus erythematosus with arthralgias, myalgias, and autoimmune phenomena with a low titre positive antinuclear antibody, coagulopathy with lupus anticoagulant, haemolytic anaemia, and thrombocytopenic purpura19. Drug-induced hypersensitivity vasculitis is common in HIV-infected patients receiving HAART19.The vasculitis associated with drug reactions typically involves small vessels and has a lymphocytic or leukocytoclastic histopathology.…”

Section: Hiv-associated Cardiology Issues: Pre-haart Vs Post-haart Pementioning

confidence: 99%

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Human immunodeficiency virus & cardiovascular risk

Bárbaro

Barbarini

2011

Indian J Med Res

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Highly active antiretroviral therapy (HAART) significantly changed the prevalence of the cardiovascular manifestations of human immunodeficiency virus (HIV)/AIDS. In developed countries, a 30 per cent reduction in the prevalence of cardiomyopathy and pericardial effusion was observed, possibly related to a reduction of opportunistic infections and myocarditis. In developing countries, however, where the availablity of HAART is limited, and the pathogenic impact of nutritional factors is significant, a 32 per cent increase was seen in the prevalence of cardiomyopathy and related high mortality rate from congestive heart failure. Also, some HAART regimens in developed countries, especially those including protease inhibitors, may cause, in a high proportion of HIV-infected patients, a lipodystrophy syndrome that is associated with an increased risk of cardiovascular events related to a process of accelerated atherosclerosis. Careful cardiac screening is warranted for patients who are being evaluated for, or who are receiving HAART regimens, particularly for those with known underlying cardiovascular risk factors, according to the most recent clinical guidelines.

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Section: Hiv-associated Cardiology Issues: Pre-haart Vs Post-haart Pementioning

confidence: 99%

“…Medical practitioners need to be especially aware of abacavir hypersensitivity reactions because of the potential for fatal outcomes. Hypersensitivity reactions of this type should always be considered as a possible aetiology for a vasculitic syndrome in an HIV-infected patient19.…”

Section: Hiv-associated Cardiology Issues: Pre-haart Vs Post-haart Pementioning

confidence: 99%

Human immunodeficiency virus & cardiovascular risk

Bárbaro

Barbarini

2011

Indian J Med Res

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“…The prevalence of rheumatic syndromes is reported to range from 11% to 70% in different studies. 3 The rheumatologic manifestations associated with HIV are reported in Table 1.…”

Section: Discussionmentioning

confidence: 99%

“…3,8 Systemic necrotizing vasculitis, leukocytoclastic vasculitis, cryoglobulinemia, and CNS vasculitis have been reported. 1,4,5 The organs that are usually involved include the following: skin, peripheral nerve, skeletal muscle, and the CNS; in addition, the lung, gastrointestinal tract, oropharynx, and kidney can also be affected, although less commonly.…”

Section: Discussionmentioning

confidence: 99%

“…Although an abnormal immune activation triggered by the exposure to an infectious agent is one of the suggested mechanisms, various theories have been proposed to explain the virus-associated vasculitis. 3,8 The virus may attack the vascular and perivascular tissue directly; alternatively, cellular or humoral immune mechanisms involved in the pathophysiology of the disease may lead to the ''in situ'' formation or to the deposition of circulating immune complexes in the vascular wall, thus resulting in inflammation (ie, vasculitis). The demonstration of vascular deposits of HIV antigens, immunoglobulins, and complement components seems to support such a pathway in the setting of an abnormal immunologic reactivity to a variety of xenoanti-gens including HIV and other opportunistic infectious agents and drugs used for the treatment.…”

Section: Discussionmentioning

confidence: 99%

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Leukocytoclastic Vasculitis and Dysesthesias in Lower Limbs

Gallerani¹,

Boari²,

Sighinolfi³

et al. 2008

Infectious Diseases in Clinical Practice

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Leukocytoclastic vasculitis may be associated with many pathological conditions such as peripheral neurological involvement shown through paresthesias or dysesthesias. Peripheral nerve damage is one of the most common neurological complications of human immunodeficiency virus infection, but the prevalence of sensory neuropathy is relatively low in asymptomatic infection. We describe the case of a 42-year-old woman in which dysesthesias and erythematous spots in the feet and lower limbs were the first demonstrations of a human immnodeficiency virus infection. (Infect Dis Clin Pract 2008;16:194-197)

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Pathogenesis of Cardiovascular Complications in the Acquired Immunodeficiency Syndrome

Bárbaro¹

2007

Immune Dysfunction and Immunotherapy in Heart Disease

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Vasculitic Syndromes in HIV-Infected Patients

Cited by 9 publications

References 58 publications

Human immunodeficiency virus & cardiovascular risk

Human immunodeficiency virus & cardiovascular risk

Leukocytoclastic Vasculitis and Dysesthesias in Lower Limbs

Pathogenesis of Cardiovascular Complications in the Acquired Immunodeficiency Syndrome

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