Erythema multiforme reactions after Pfizer/BioNTech (BNT162b2) and Moderna (mRNA-1273) COVID-19 vaccination: A case series

Karataş, Elif; Nazim, A. A.; Patel, Parth; Vaidya, Toral; Drew, G. Scott; Amin, Sanober; Keyes, Ashley A.; Fonseca, Maira; Mir, Adnan; Halverstam, Caroline

doi:10.1016/j.jdcr.2021.12.002

Cited by 8 publications

(4 citation statements)

References 8 publications

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“…Table 1 [ 8 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 ] and Table 2 [ 39 40 41 42 43 44 ] presents the results obtained from evaluation of 31 eligible articles retrieved from the databases.…”

Section: Resultsmentioning

confidence: 99%

Occurrence of erythema multiforme following COVID-19 vaccination: a review

Yousefian

Khadivi

2023

Clin Exp Vaccine Res

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The fast development of vaccines against the novel coronavirus disease is among the most critical steps taken to control this potentially fatal viral disease. Like other vaccines, the coronavirus disease 2019 (COVID-19) vaccines can also cause unwanted reactions. Erythema multiforme (EM) is among the oral mucocutaneous side effects of COVID-19 vaccines. This study aimed to comprehensively review the reported cases of EM since the global onset of COVID-19 vaccination. Data from 31 relevant studies regarding the type and dose of COVID-19 vaccines administered, time of initiation of symptoms, age, and gender of patients, site of involvement, patients’ medical history, and treatment options were extracted. In total, 90 patients were identified with EM as a side effect of COVID-19 vaccination across studies. EM had the highest frequency after receiving the first dose of mRNA vaccines in older individuals. The first symptoms of EM appeared in less than 3 days in 45% and after 3 days in 55% of patients. EM is not a common side effect of COVID-19 vaccination, and fear of its occurrence should not impede vaccination.

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Section: Resultsmentioning

confidence: 99%

Occurrence of erythema multiforme following COVID-19 vaccination: a review

Yousefian

Khadivi

2023

Clin Exp Vaccine Res

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“…Several lesions presented with erythema multiforme and their histopathology was as follows: lymphohistiocytic infiltrates in the superficial dermis 54,98–102 and interface dermatitis, 103 vacuolar damage of the basal cells, 54,98 crusted epidermis with basket weave keratin plus central hyper granulosis, subepidermal cleft, and occasional apoptotic keratinocytes. 47,98,103 Toxic epidermal necrosis (TEN) and Steven–Johnson disease were evaluated microscopically in 3 studies; histopathologic results consisted of full-thickness epidermal necrosis and dermal–epidermal separation plus keratinocytes necrosis, 100,104,105 and subepidermal blister containing dense fibrinous exudate in one of the studies.…”

Section: Resultsmentioning

confidence: 99%

“…96 Erythema Multiforme/Steven-Johnson Disease/Toxic Epidermal Necrosis Several lesions presented with erythema multiforme and their histopathology was as follows: lymphohistiocytic infiltrates in the superficial dermis 54,[98][99][100][101][102] and interface dermatitis, 103 vacuolar damage of the basal cells, 54,98 crusted epidermis with basket weave keratin plus central hyper granulosis, subepidermal cleft, and occasional apoptotic keratinocytes. 47,98,103 Toxic epidermal necrosis (TEN) and Steven-Johnson disease were evaluated microscopically in 3 studies; histopathologic results consisted of full-thickness epidermal necrosis and dermal-epidermal separation plus keratinocytes necrosis, 100,104,105 and subepidermal blister containing dense fibrinous exudate in one of the studies. 105 Also, an extremely rare case reported with similar manifestation of TEN did show evidence of a neutrophil-rich subepidermal blister with IgA dominancy in the epidermal basement, which was consistent with a TEN-like presentation of linear IgA bullous dermatosis.…”

Section: Papulosquamous Lesionsmentioning

confidence: 99%

A Systematic Review of Histopathologic Surveys on Mucocutaneous Biopsies in Patients Developed COVID-19 Vaccine-Related Dermatologic Manifestations

Salehi

Sadeghi

Kalantari

et al. 2022

The American Journal of Dermatopathology

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“…Erythema multiforme was reported in less than 1% of cases [ 79 ••, 92 , 94 ••]. Erythema multiforme (EM) has been associated with triggers such as viruses and vaccines in the past, yet there are very few reports to date of EM after COVID-19 vaccination [ 111 , 112 ]. These lesions are described as “predominantly acral, targetoid papules, made up of three concentric distinct zones” [ 111 ].…”

Section: Cutaneous Reactions To Covid-19 Vaccinesmentioning

confidence: 99%

Viruses, Variants, and Vaccines: How COVID-19 Has Changed the Way We Look at Skin

Singh

Freeman

2022

Curr Derm Rep

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Purpose of Review This review aims to evaluate the spectrum of cutaneous reactions after both SARS-CoV-2 infection and COVID-19 vaccination while simultaneously understanding the evolution of the field of dermatology in the face of an ongoing pandemic. Recent Findings The most commonly reported cutaneous reactions after COVID-19 infection in the literature to date include morbilliform or maculopapular rashes, chilblains, and urticaria. The incidence of cutaneous reactions after COVID-19 vaccination was 9% in larger cohort studies and more commonly occurred after mRNA-based COVID-19 vaccines than adenovirus vector vaccines. The most frequently reported cutaneous reactions after COVID-19 vaccines were delayed large local reactions, local injection site reactions, urticarial eruptions, and morbilliform eruptions. Summary With the ongoing pandemic, and continued development of new COVID-19 variants and vaccines, the landscape of cutaneous reactions continues to rapidly evolve. Dermatologists have an important role in evaluating skin manifestations of the virus, as well as discussion and promoting COVID-19 vaccination for their patients.

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Erythema multiforme reactions after Pfizer/BioNTech (BNT162b2) and Moderna (mRNA-1273) COVID-19 vaccination: A case series

Cited by 8 publications

References 8 publications

Occurrence of erythema multiforme following COVID-19 vaccination: a review

Occurrence of erythema multiforme following COVID-19 vaccination: a review

A Systematic Review of Histopathologic Surveys on Mucocutaneous Biopsies in Patients Developed COVID-19 Vaccine-Related Dermatologic Manifestations

Viruses, Variants, and Vaccines: How COVID-19 Has Changed the Way We Look at Skin

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