“…In the present case, neither of the 2 cutaneous diseases, GCS and EM, had developed after the first dose of measles-rubella vaccine, but they developed following the second dose of the same vaccine. To date, most cases of vaccine-induced cutaneous diseases have occurred at the first-dose vaccinations ( 6 – 10 , 12 ), although several case reports have described patients who developed these diseases after the second-dose vaccinations ( 11 , 14 , 15 ). A possible explanation for the phenomenon that GCS and EM occurred at the second, but not the first, dose of vaccine in the present case is that both GCS and EM developed as a result of allergic reactions to vaccine components (e.g., adjuvants, stabilizers, and preservatives) that required sensitization by the first dose of vaccination.…”